Chemistry and Biochemistry

Search CurateND

Search criteria:

Department or Unit: Chemistry and Biochemistry remove ×
Clear all

List of files deposited in CurateND that match your search criteria

  • Inventor(s):
    Olaf G. Wiest, Frederick R. Maxfield, Paul Helquist
    Patent Number:
    US 9333222 B2
    Description:

    Embodiments herein relate to the field of lysosomal storage disorders, and, more specifically, to methods of treating lysosomal storage disorders such as Niemann-Pick type C disease, for instance with inhibitors of histone deacetylases, particularly inhibitors of class 1 histone deacetylases. In various embodiments, methods of treating Niemann-Pick type C disease with inhibitors of class 1 histone deacetylases are described.

    Date Issued:
    2016-05-10
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Robert M. Williams, James E. Bradner, Albert Bowers, Tenaya Newkirk, Olaf G. Wiest
    Patent Number:
    US 9186402 B2
    Description:

    Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.

    Date Issued:
    2015-11-17
    Record Visibility:
    Public
    Resource Type
    Patent