Chemistry and Biochemistry
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- Inventor(s):
- Olaf G. Wiest, Paul Helquist, Frederick R. Maxfield
- Patent Number:
- US 9333222 B2
- Description:
Embodiments herein relate to the field of lysosomal storage disorders, and, more specifically, to methods of treating lysosomal storage disorders such as Niemann-Pick type C disease, for instance with inhibitors of histone deacetylases, particularly inhibitors of class 1 histone deacetylases. In various embodiments, methods of treating Niemann-Pick type C disease with inhibitors of class 1 histone deacetylases are described.
- Date Issued:
- May 10, 2016
- Record Visibility:
- Public
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- Inventor(s):
- Robert M. Williams, James E. Bradner, Albert A. Bowers, Tenaya L. Newkirk, Olaf G. Wiest
- Patent Number:
- US 8513290 B2
- Description:
Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
- Date Issued:
- 2013-08-20
- Record Visibility:
- Public
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