Chemistry and Biochemistry

Search CurateND

Search criteria:

Department or Unit: Chemistry and Biochemistry remove ×
Clear all

List of files deposited in CurateND that match your search criteria

  • Inventor(s):
    Paul Helquist, Joakim Loefstedt
    Patent Number:
    US 7235688 B2
    Description:

    A process for preparing unsaturated esters useful as intermediates for HDAC inhibitors, by reacting an aldehyde or ketone having the following formula I: ##STR00001## wherein R.sub.1 is an aromatic group or a combined aliphatic and aromatic group; X is –O–, –S–, –COO–, –OOC–, –CONR.sub.7–, or –R.sub.7NCO–; L.sub.1 an aliphatic linking group, an aromatic linking group, or a combined aliphatic and aromatic linking group; R.sub.2 and R.sub.3 are each independently hydrogen, a hydroxy…

    Date Issued:
    2007-06-26
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Paul Helquist
    Patent Number:
    US 6730788 B2
    Description:

    Process for preparing 1,10-phenanthroline ligands represented by the formula ##STR1## which comprises coupling a 1,10-phenanthroline of the formula ##STR2## with a ketone e.g. a dialkyl, cycloalkyl or bicycloalkyl ketone with a metal coupling reagent, preferably a lanthanide II e.g. samarium II, wherein R is hydrogen, alkyl, cycloalkyl, bicycloalkyl or aryl e.g. phenyl. The hydroxy group of the product may be converted to derivatives e.g. esters and ethers to form additional ligands. The hydr…

    Date Issued:
    2004-05-04
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Paul Helquist, Carlo Cocito
    Patent Number:
    US 5587475 B2
    Description:

    Derivatized type A virginiamycins having a reactive functionalized side chain, and a process for making the virginiamycin derivatives. The side chain contains a thioether linkage and a reactive group, such as a carboxylate ester or free carboxylic acid group.

    Date Issued:
    1996-12-24
    Record Visibility:
    Public
    Resource Type
    Patent