Chemistry and Biochemistry
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- Inventor(s):
- Olaf G. Wiest, Paul Helquist, Frederick R. Maxfield
- Patent Number:
- US 9333222 B2
- Description:
Embodiments herein relate to the field of lysosomal storage disorders, and, more specifically, to methods of treating lysosomal storage disorders such as Niemann-Pick type C disease, for instance with inhibitors of histone deacetylases, particularly inhibitors of class 1 histone deacetylases. In various embodiments, methods of treating Niemann-Pick type C disease with inhibitors of class 1 histone deacetylases are described.
- Date Issued:
- May 10, 2016
- Record Visibility:
- Public
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- Inventor(s):
- Marvin J. Miller
- Patent Number:
- US 4595532 B2
- Description:
N-Mono or N-disubstituted methyl-2-azetidinones are provided via cyclization of .beta.-hydroxy or .beta.-halo substituted acid sec-amides wherein the amide nitrogen is substituted with a mono- or di-substituted methyl group having activating substituents. Cyclization of .beta.-hydroxy acid amides is mediated by triphenylphosphine-dialkylazodicarboxylate while cyclization of .beta.-halo acid amides is mediated by strong bases e.g. lithium dialkylamides. E.g. Diethyl amino-protected L-serylamin…
- Date Issued:
- 1986-06-17
- Record Visibility:
- Public
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- Inventor(s):
- Bradley D. Smith, Arunkumar Easwaran
- Patent Number:
- US 8273875 B2
- Description:
Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to novel near-infrared dyes that are photostable and resistant to quenching. The dyes belong to a novel family of squaraine rotaxanes, and they are particularly well-suited for use in biological applications. Also disclosed are methods of synthesizing the dyes and methods of using the dyes.
- Date Issued:
- 2012-09-25
- Record Visibility:
- Public
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4
Patent
- Inventor(s):
- Marvin J. Miller, Yanping Xu
- Patent Number:
- US 6310058 B2
- Description:
Compounds represented by the formula [1] ##STR1## R.sub.1 is H or a substituent; R.sub.2 and R.sub.3 are C.sub.1 -C.sub.3 alkyl; R.sub.4 is siderophore group e.g. CH.sub.3 –(CH.sub.2).sub.n –C(O)–N(OH)–(CH.sub.2).sub.m – with n=10-22, m=2-6; X is O, S, or NH; X.sub.1 is O or NH; Y is H or alkyl; Z is H or substituted amino, e.g., t-BocNH or CbzNH, and r is 2-4; are useful in the method provided for treating tuberculosis. [1] is prepared by coupling [7], wherein HX.sub.1 is HO– or H.sub….
- Date Issued:
- 2001-10-30
- Record Visibility:
- Public
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- Inventor(s):
- Marvin J. Miller
- Patent Number:
- US 4675399 B2
- Description:
Process for N-acyloxy or sulfooxy 2-azetidinones comprising O-acylation of a .beta.-hydroxy or .beta.-halo hydroxamic acid, and cyclizing the O-acylhydroxamate with TPP-CCl.sub.4 -TEA or with TPP-dialkylazodicarboxylate to the N-acyloxy-2-azetidinone. Solvolysis of the acyl group provides an N-hydroxy-2-azetidinone. e.g., N-Cbz-L-serine is converted to the O-acetyl hydroxamate, cyclized and solvolyzed to N-hydroxy-3-(Cbz-amino)-2-azetidinone. The N-hydroxy-2-azetidinones are useful intermedia…
- Date Issued:
- 1987-06-23
- Record Visibility:
- Public
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- Inventor(s):
- Marvin J. Miller
- Patent Number:
- US 5266468 B2
- Description:
.beta.-Hydroxy-.alpha.-amino acids are obtained via serine hydroxymethyltransferase catalyzed condensation of aldehydes with glycine. The predominant product with most aldehydes is the L-erythro diastereomer. For example, succinic semialdehyde methylester is condensed with glycine in the process to provide L-erythro .alpha.-amino hydroxy adipic acid mono methyl ester.
- Date Issued:
- 1993-11-30
- Record Visibility:
- Public
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- Inventor(s):
- Gaetano Francis D'Alelio
- Patent Number:
- US 3639348 B2
- Description:
The copolymers disclosed herein are of propargyl acrylate and methacrylate. Polymerization of propargyl acrylate and methacrylate in free radical systems generally results in crosslinked or gelled products since the free radicals will activate polymerization through the acetylenic as well as through the acrylic unsaturation. Therefore the copolymers are advantageously prepared byanionic polymerization. The comonomers are those which are copolymerizable with acrylates and methacrylates inanion…
- Date Issued:
- 1972-02-01
- Record Visibility:
- Public
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- Inventor(s):
- Gaetano Francis D'Alelio
- Patent Number:
- US 4058505 B2
- Description:
Aromatic polyimides with amine end groups are chain-extended (molecular weight increased) by reacting them with aromatic di- or tri- anhydrides. The reaction can either be at a temperature above the melting point of the reactants or in solvents for the reactants. The polyimides can be shaped and formed prior to chain-extending.
- Date Issued:
- 1977-11-15
- Record Visibility:
- Public
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- Inventor(s):
- Chi-Nung W. Hsiao, Marvin J. Miller
- Patent Number:
- US 4845229 B2
- Description:
A stereoselective process for chiral intermediates to 1-carbapenem and 1-carbacephalosporins is provided comprising the use of an N-acyl-(4R)-substituted-1,3-thiazolidine-2-thione as a chiral auxiliary in boron enolate mediated aldol condensation with a protected-.beta.-keto ester aldehyde. E.g., benzyl 3,3-(ethylenedioxy)-4-formylbutyrate is condensed with the boron enolate formed with n-butyryl (4R)-methoxycarbonyl-1,3-thiazolidine-2-thione to provide benzyl 3,3-ethylenedioxy-(5R)-hydroxy-6…
- Date Issued:
- 1989-07-04
- Record Visibility:
- Public
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- Inventor(s):
- Gaetano Francis D'Alelio
- Patent Number:
- US 4026871 B2
- Description:
Aromatic polyimides with phenolic end groups are chain-extended (molecular weight increased) by reacting them with formaldehyde, compounds capable of generating formaldehyde under the reaction conditions or hexamethylene tetramine in the presence of a catalytic amount of lime. These polyimides can be shaped and formed prior to the chain-extending. The aromatic polyimides appropriate for chain-extending are formed by the reaction of aromatic dianhydrides, aromatic diamines and phenolic compoun…
- Date Issued:
- 1977-05-31
- Record Visibility:
- Public
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11
Patent
- Inventor(s):
- Marvin J. Miller, Jingdan Hu
- Patent Number:
- US 6403623 B2
- Description:
Method for treating tuberculosis with 2-(2-substituted-phenyl)-2-oxazolines and related 5-membered heterocycles represented by the formula ##STR1## Y.sub.1 is e.g. an ester or amide forming group, and X is O, S, or NH; and pharmaceutically acceptable formulations useful therein are provided. A preferred method comprises administering (S)-benzyl2-[2-(benzyloxy)phenyl]-2-oxazoline-4-carboxylate in a suitable formulation. The compounds of the above formula are prepared by known methods, e.g. the…
- Date Issued:
- 2002-06-11
- Record Visibility:
- Public
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12
Patent
- Inventor(s):
- Gaetano Francis D'Alelio
- Patent Number:
- US 4118377 B2
- Description:
Processes for increasing the molecular weight of bis-maleimides are provided. The bis-maleimides are reacted with certain cyclic dienes to form reversible adducts. These adducts, upon elimination of the cyclic diene, yield an extension of the bis-maleimides to higher molecular weight polymers, ultimately to thermally stable, infusible polymers. The process can be interrupted to yield tractable polymers which are also convertible to cross-linked, infusible products. Modifications of the proces…
- Date Issued:
- 1978-10-03
- Record Visibility:
- Public