Chemistry and Biochemistry

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  • Inventor(s):
    Richard E. Taylor, Yue Chen
    Patent Number:
    US 6900331 B2
    Description:

    The present invention provides the following new compounds: ®-C14-methyl-epothilone B, (S)-C14-methyl-epothilone B, (S)-C14-methyl-epothilone D, and ®-C14-methyl-epothilone D and methods for synthesizing these compounds.

    Date Issued:
    2005-05-31
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Paul Helquist, Joakim Loefstedt
    Patent Number:
    US 7235688 B2
    Description:

    A process for preparing unsaturated esters useful as intermediates for HDAC inhibitors, by reacting an aldehyde or ketone having the following formula I: ##STR00001## wherein R.sub.1 is an aromatic group or a combined aliphatic and aromatic group; X is –O–, –S–, –COO–, –OOC–, –CONR.sub.7–, or –R.sub.7NCO–; L.sub.1 an aliphatic linking group, an aromatic linking group, or a combined aliphatic and aromatic linking group; R.sub.2 and R.sub.3 are each independently hydrogen, a hydroxy…

    Date Issued:
    2007-06-26
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller
    Patent Number:
    US 4820815 B2
    Description:

    The invention provides azetidinones of the formula ##STR1## where R.sub.4 is hydrogen, amino or protected amino; R.sup.0 is H when R.sub.4 is amino or protected amino, or C.sub.1 -C.sub.4 alkyl when R.sub.4 is H; R.sub.1 is H, CH.sub.3, –CH.sub.2 –.sub.n Y where Y is OH, protected OH, –CH.sub.2 OH, protected –CH.sub.2 OH, halogen, COOH or protected COOH; n is 1 or 2; –CH.sub.2 –C(O)SR.sub.1 ‘ where R.sub.1 ’ is e.g., C.sub.1 -C.sub.4 alkyl; R.sub.2 is H or protecting group and R…

    Date Issued:
    1989-04-11
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Chi-Nung W. Hsiao, Marvin J. Miller
    Patent Number:
    US 4845229 B2
    Description:

    A stereoselective process for chiral intermediates to 1-carbapenem and 1-carbacephalosporins is provided comprising the use of an N-acyl-(4R)-substituted-1,3-thiazolidine-2-thione as a chiral auxiliary in boron enolate mediated aldol condensation with a protected-.beta.-keto ester aldehyde. E.g., benzyl 3,3-(ethylenedioxy)-4-formylbutyrate is condensed with the boron enolate formed with n-butyryl (4R)-methoxycarbonyl-1,3-thiazolidine-2-thione to provide benzyl 3,3-ethylenedioxy-(5R)-hydroxy-6…

    Date Issued:
    1989-07-04
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Michael M. Crouse, Albert E. Miller, Juan Jiang, David T. Crouse, Subash C. Basu
    Patent Number:
    US 6869671 B2
    Description:

    A thin film based nanoporous alumina template has been developed which allows the in situ removal of an electrically insulating alumina barrier layer at the pore bases. This barrier free nanoporous system has great utility for electrodeposition of a wide variety of nanowire materials. An exemplary multilayer thin film precursor is provided comprising Al (anodization layer), Ti (diffusion barrier) and Pt (active electrode) on a Si substrate. Aluminum anodization in sulfuric acid with a subsequ…

    Date Issued:
    2005-03-22
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Mijoon Lee, Masahiro Ikejiri, Mayland Chang, Rafael Fridman, Shahriar Mobashery
    Patent Number:
    US 7928127 B2
    Description:

    The present invention provides novel compounds of formulas I-IX, as described herein. Also provided are compositions of compounds of formulas I-IX, methods of making compounds of formulas I-IX, and methods of using compounds of formulas I-IX. The compounds of the invention can be used to inhibit matrix metalloproteinases, and are useful to treat conditions and diseases associated therewith.

    Date Issued:
    2011-04-19
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Gaetano Francis D'Alelio
    Patent Number:
    US 4075171 B2
    Description:

    A process for preparing substantially completely cyclized aromatic polyimides, either monomeric, oligomeric or polymeric, is provided. The process involved the reaction of a mixture of at least one tetracarboxylic acid dianhydride, at least one aromatic diamine and an .alpha.,.beta.-carboxylic acid monoanhydride in at least one aromatic phenol, preferably cresols, in the presence of an organic azeotroping agent such as a cyclic hydrocarbon, preferably benzene, until substantially all of the w…

    Date Issued:
    1978-02-21
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller, Julia M. Dolence, Manuka Ghosh
    Patent Number:
    US 5783689 B2
    Description:

    5’-O-Acyl-5-fluorouridines and 5’-O-acyl-5-sluorocytidines are prepared by the direct acylation of the 5’-hydroxyl group with amino acids under Mitsunobu conditions and the amino acyl derivatives are coupled with other amino acids or peptides to provide antibacterial and antifungal derivatives of the nucleosides. For example, 5-fluorouridine is acylated at the 5’-hydroxyl group with an amino protected L-valine and the acylation product is deprotected to provide 5’-O-(L-val…

    Date Issued:
    1998-07-21
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Gaetano Francis D'Alelio
    Patent Number:
    US 3897395 B2
    Description:

    Aromatic polyimides with reactive end groups are cured by coupling together by addition or condensation to increase molecular weight with little or no by-product formation. These polyimides can be shaped and formed prior to the coupling. The aromatic polyimides appropriate for coupling are formed by the reaction of an aromatic dianhydride and an aromatic diamine in ratios to provide the appropriate end groups, or by including in the reaction mixture a compound which will provide reactive end …

    Date Issued:
    1975-07-29
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Gaetano Francis D'Alelio
    Patent Number:
    US 3996196 B2
    Description:

    Polyimide-metallo-phthalocyanines and processes for their preparation are provided. The products have the structural formula: ##STR1## where R’ is an aromatic organic radical, the two carbon atoms attached thereto being attached to separate and adjacent carbon atoms in the aromatic radical, M is derived from a polyvalent metal or its salt, said polyvalent metal having an atomic number of at least 12 and G is an aromatic imide of the formula: ##STR2## WHEREIN Ar is a divalent aromatic orga…

    Date Issued:
    1976-12-07
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Bradley D. Smith, Jennifer A. Riggs
    Patent Number:
    US 5800624 B2
    Description:

    Plasticized liquid membranes and processes for separating monosaccharides from disaccharides and from other monosaccharides employing the membranes are provided. Fructose is separated from glucose via the membrane process to provide fructose in concentrations sufficient for HFS (high fructose syrup) and sucrose, glucose and fructose are separated from crude sources such as molasses, sugar cane juice and beet sugar juice. The plasticized membranes are prepared by dissolving a lipophilic polyme…

    Date Issued:
    1998-09-01
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Gaetano Francis D'Alelio
    Patent Number:
    US 4197397 B2
    Description:

    Aromatic polyimides with anhydride end groups are chain-extended (molecular weight increased) by reacting them with aromatic diamines or diamine terminated imide oligomers. The reaction can either be at a temperature above the melting point of the reactants or in solvents for the reactants. These polyimides can be shaped and formed prior to chain-extending.

    Date Issued:
    1980-04-08
    Record Visibility:
    Public
    Resource Type
    Patent