Chemistry and Biochemistry

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  • Author(s):
    Patricia M. Schnepp, Dennis D. Lee, Ian H. Guldner, Treasa K. O'Tighearnaigh, Erin N. Howe, Bhavana Palakurthi, Kaitlyn E. Eckert, Tiffany A. Toni, Brandon L. Ashfeld, Siyuan Zhang
    Abstract:

    The impact of altered amino acid metabolism on cancer progression is not fully understood. We hypothesized that a metabolic transcriptome shift during metastatic evolution is crucial for brain metastasis. Here, we report a powerful impact in this setting caused by epigenetic upregulation of glutamate decarboxylase 1 (GAD1), a regulator of the GABA neurotransmitter metabolic pathway. In cell-based culture and brain metastasis models, we found that downregulation of the DNA methyltransferase DN…

    Date Published:
    2017-04
  • 2

    Article

    Author(s):
    Jakub Plášil, Anthony R. Kampf, Peter C. Burns
    Abstract:

    Redcanyonite (IMA2016-082), (NH4)2Mn(UO2)4O4(SO4)24, occursunderground in the Blue Lizard mine, Red Canyon, White Canyon district,San Juan County, Utah, USA. It occurs with natrozippeite, brochantite, devilline, posnjakite, johannite, gypsum, bobcookite, pickingerite, pentahydrite, and the NH4-analog of zippeite, ammoniozippeite. Redcanyonite occurs as radial aggregates of red-orange needles and blades individually reaching up to 0.2 mm in length, with aggregates measuring up to 1 mm i…

    Date Published:
    2018-05
  • Author(s):
    Colin Flinders, Shannon M. Mumenthaler, Amanda B. Hummon, Xin Liu
    Abstract:

    Patient-derived colorectal tumor organoids (CTOs) closely recapitulate the complex morphological, phenotypic, and genetic features observed in in vivo tumors. Therefore, evaluation of drug distribution and metabolism in this model system can provide valuable information to predict the clinical outcome of a therapeutic response in individual patients. In this report, we applied matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) to examine the spatial distribution…

    Date Published:
    2018-03
  • Author(s):
    Scott Shaw, Wenqi Liu, Cesar Fernando Azael Gomez Duran, Cynthia Schreiber, Maria de Lourdes Betancourt Mendiola, Canjai Zhai, Felicia Roland, Simon Padanilam, Bradley Smith
    Abstract:

    New fluorescent molecular probes, which can selectively target specific cell surface receptors, are needed for microscopy, in vivo imaging, and image guided surgery. The preparation of multivalent probes using standard synthetic chemistry can be a laborious process due to low reaction yields caused by steric effects. In this study, fluorescent molecular probes were prepared by a programmed non‐covalent pre‐assembly process that used a near‐infrared fluorescent squaraine dye to thread a macroc…

    Date Published:
    2018