Search CurateND

Search criteria:

Department or Unit: College of Science remove × Department or Unit: University of Notre Dame remove × Type of Work: Patent remove ×
Clear all

List of files deposited in CurateND that match your search criteria

  • Inventor(s):
    John H. Adams, Malcolm J. Fraser, Bharath Balu, Douglas A. Shoue
    Patent Number:
    US 7932088 B2
    Description:

    The present invention provides molecular methods for efficiently transforming the genome of common disease-transmitting parasites, such as Plasmodium falciparum. The transformation efficiencies are improved up to 100 times over those conventionally known. The methods provide high saturation of the target parasite genome, of 50% or greater, and target non-specifically TTAA-rich sites in the parasite genome. The invention also discloses a model that may be used to functionally annotate the geno…

    Date Issued:
    2011-04-26
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Richard E. Taylor, Yue Chen
    Patent Number:
    US 6900331 B2
    Description:

    The present invention provides the following new compounds: ®-C14-methyl-epothilone B, (S)-C14-methyl-epothilone B, (S)-C14-methyl-epothilone D, and ®-C14-methyl-epothilone D and methods for synthesizing these compounds.

    Date Issued:
    2005-05-31
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Paul Helquist, Joakim Loefstedt
    Patent Number:
    US 7235688 B2
    Description:

    A process for preparing unsaturated esters useful as intermediates for HDAC inhibitors, by reacting an aldehyde or ketone having the following formula I: ##STR00001## wherein R.sub.1 is an aromatic group or a combined aliphatic and aromatic group; X is –O–, –S–, –COO–, –OOC–, –CONR.sub.7–, or –R.sub.7NCO–; L.sub.1 an aliphatic linking group, an aromatic linking group, or a combined aliphatic and aromatic linking group; R.sub.2 and R.sub.3 are each independently hydrogen, a hydroxy…

    Date Issued:
    2007-06-26
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Paul D. Shirk, Malcolm J. Fraser, Teresa A. Elick, Omaththage P. Perera
    Patent Number:
    US 6551825 B2
    Description:

    The present invention is directed to nucleic acid and amino acid sequences for transformation constructs containing piggyBac or tagalong transposable elements. These constructs allow for the precise excision and insertion of heterologous DNA into a host cell.

    Date Issued:
    2003-04-22
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller
    Patent Number:
    US 4820815 B2
    Description:

    The invention provides azetidinones of the formula ##STR1## where R.sub.4 is hydrogen, amino or protected amino; R.sup.0 is H when R.sub.4 is amino or protected amino, or C.sub.1 -C.sub.4 alkyl when R.sub.4 is H; R.sub.1 is H, CH.sub.3, –CH.sub.2 –.sub.n Y where Y is OH, protected OH, –CH.sub.2 OH, protected –CH.sub.2 OH, halogen, COOH or protected COOH; n is 1 or 2; –CH.sub.2 –C(O)SR.sub.1 ‘ where R.sub.1 ’ is e.g., C.sub.1 -C.sub.4 alkyl; R.sub.2 is H or protecting group and R…

    Date Issued:
    1989-04-11
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Chi-Nung W. Hsiao, Marvin J. Miller
    Patent Number:
    US 4845229 B2
    Description:

    A stereoselective process for chiral intermediates to 1-carbapenem and 1-carbacephalosporins is provided comprising the use of an N-acyl-(4R)-substituted-1,3-thiazolidine-2-thione as a chiral auxiliary in boron enolate mediated aldol condensation with a protected-.beta.-keto ester aldehyde. E.g., benzyl 3,3-(ethylenedioxy)-4-formylbutyrate is condensed with the boron enolate formed with n-butyryl (4R)-methoxycarbonyl-1,3-thiazolidine-2-thione to provide benzyl 3,3-ethylenedioxy-(5R)-hydroxy-6…

    Date Issued:
    1989-07-04
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Michael M. Crouse, Albert E. Miller, Juan Jiang, David T. Crouse, Subash C. Basu
    Patent Number:
    US 6869671 B2
    Description:

    A thin film based nanoporous alumina template has been developed which allows the in situ removal of an electrically insulating alumina barrier layer at the pore bases. This barrier free nanoporous system has great utility for electrodeposition of a wide variety of nanowire materials. An exemplary multilayer thin film precursor is provided comprising Al (anodization layer), Ti (diffusion barrier) and Pt (active electrode) on a Si substrate. Aluminum anodization in sulfuric acid with a subsequ…

    Date Issued:
    2005-03-22
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Mijoon Lee, Masahiro Ikejiri, Mayland Chang, Rafael Fridman, Shahriar Mobashery
    Patent Number:
    US 7928127 B2
    Description:

    The present invention provides novel compounds of formulas I-IX, as described herein. Also provided are compositions of compounds of formulas I-IX, methods of making compounds of formulas I-IX, and methods of using compounds of formulas I-IX. The compounds of the invention can be used to inhibit matrix metalloproteinases, and are useful to treat conditions and diseases associated therewith.

    Date Issued:
    2011-04-19
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Gaetano Francis D'Alelio
    Patent Number:
    US 4075171 B2
    Description:

    A process for preparing substantially completely cyclized aromatic polyimides, either monomeric, oligomeric or polymeric, is provided. The process involved the reaction of a mixture of at least one tetracarboxylic acid dianhydride, at least one aromatic diamine and an .alpha.,.beta.-carboxylic acid monoanhydride in at least one aromatic phenol, preferably cresols, in the presence of an organic azeotroping agent such as a cyclic hydrocarbon, preferably benzene, until substantially all of the w…

    Date Issued:
    1978-02-21
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller, Julia M. Dolence, Manuka Ghosh
    Patent Number:
    US 5783689 B2
    Description:

    5’-O-Acyl-5-fluorouridines and 5’-O-acyl-5-sluorocytidines are prepared by the direct acylation of the 5’-hydroxyl group with amino acids under Mitsunobu conditions and the amino acyl derivatives are coupled with other amino acids or peptides to provide antibacterial and antifungal derivatives of the nucleosides. For example, 5-fluorouridine is acylated at the 5’-hydroxyl group with an amino protected L-valine and the acylation product is deprotected to provide 5’-O-(L-val…

    Date Issued:
    1998-07-21
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Carol Tanner
    Patent Number:
    US 6445869 B2
    Description:

    A sealed fiber-optic bundle feedthrough by which a multitude of fiber-optic elements may be passed through an opening or port in a wall or structure separating two environments at different pressures or temperatures while maintaining the desired pressure or temperature in each environment. The feedthrough comprises a rigid sleeve of suitable material, a bundle of individual optical fibers, and a resin-based sealing material that bonds the individual optical fibers to each other and to the rig…

    Date Issued:
    2002-09-03
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Albert-László Barabási, Boldizsár Jankó, Choongseop Lee, Imre Derenyi
    Patent Number:
    US 6469880 B2
    Description:

    A system and method for removing unwanted magnetic flux from a superconductor. A device can generate a controllable electric field potential using an asymmetric electric field potential to efficiently remove the magnetic flux in different directions in the superconductor.

    Date Issued:
    2002-10-22
    Record Visibility:
    Public
    Resource Type
    Patent