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  • Inventor(s):
    Bradley D. Smith, Arunkumar Easwaran
    Patent Number:
    US 8273875 B2
    Description:

    Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to novel near-infrared dyes that are photostable and resistant to quenching. The dyes belong to a novel family of squaraine rotaxanes, and they are particularly well-suited for use in biological applications. Also disclosed are methods of synthesizing the dyes and methods of using the dyes.

    Date Issued:
    2012-09-25
    Resource Type
    Patent
  • Inventor(s):
    Bradley D. Smith
    Patent Number:
    US 7179616 B2
    Description:

    The present invention relates generally to a method and compound for sensing the presence of anionic phospholipids, especially phosphatidylserine, on the surface of vesicles and cells. Upon introducing a compound having the structure below to a sample of cells or vesicles, the compound binds to anionic phopholipids on the surface of cells or vesicles and the presence of the compound is detected reflecting the presence of anionic phospholipids in the sample ##STR00001##

    Date Issued:
    2007-02-20
    Resource Type
    Patent
  • Inventor(s):
    Bradley D. Smith, Jennifer A. Riggs
    Patent Number:
    US 5800624 B2
    Description:

    Plasticized liquid membranes and processes for separating monosaccharides from disaccharides and from other monosaccharides employing the membranes are provided. Fructose is separated from glucose via the membrane process to provide fructose in concentrations sufficient for HFS (high fructose syrup) and sucrose, glucose and fructose are separated from crude sources such as molasses, sugar cane juice and beet sugar juice. The plasticized membranes are prepared by dissolving a lipophilic polyme…

    Date Issued:
    1998-09-01
    Resource Type
    Patent
  • Inventor(s):
    Bradley D. Smith
    Patent Number:
    US 8389223 B2
    Description:

    Embodiments of the present invention are generally directed to compositions comprising a class of molecular probes for detecting the presence of anionic cell surfaces. Embodiments include compositions that are enriched for these compositions and preparations, particularly preparations suitable for use as laboratory/clinical reagents and diagnostic indicators, either alone or as part of a kit. An embodiment of the invention provides for a highly selective agent useful in the discernment and id…

    Date Issued:
    2013-03-05
    Resource Type
    Patent
  • Inventor(s):
    Bradley D. Smith
    Patent Number:
    US 9353092 B2
    Description:

    The present disclosure provides compositions and methods for the synthesis and use of croconaine compounds. The disclosed compounds are easily prepared from croconic acid. A halothiophene is reacted with an alkanolamine, the resulting aminothiophene is modified by appending a desired functional group to the hydroxyl group, and the modified aminothiophene is reacted with croconic acid to form the final compound. Applications of such croconaine compounds include photothermal imaging, phototherm…

    Date Issued:
    2016-05-31
    Resource Type
    Patent