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  • Inventor(s):
    Mark A. Suckow, William R. Wolter, Morris Pollard
    Patent Number:
    US 8257715 B2
    Description:

    Compositions comprising a tissue vaccine that include a mixture of heterogeneous tissue obtained from tumors and connective tissues. Vaccines comprising these compositions are also provided, as well as methods of using the vaccines in the treatment and/or inhibition of tumor growth, and particularly prostate tumor growth and cancers. The preparations may be defined as vaccines comprising tumor cells and connective (stromal) tissues derived from xenogeneic animals. Preparations comprising the …

    Date Issued:
    2012-09-04
    Resource Type
    Patent
  • Inventor(s):
    Mark A. Suckow, William R. Wolter
    Patent Number:
    US 8802113 B2
    Description:

    Compositions suitable for use as adjuvants in the preparation of vaccines, particularly those vaccines useful in the treatment of cancer, are provided. Methods for inhibiting tumor growth in an animal are also disclosed. Methods for immunizing an animal against cancer, such as prostate cancer, are also described. The adjuvants described are comprised of an extracellular matrix material, such as small intestinal submucosal (SIS) tissue. The preparations may take the form of sheets, gels, liqui…

    Date Issued:
    2014-08-12
    Resource Type
    Patent
  • Inventor(s):
    Mark A. Suckow, Michael C. Hiles
    Patent Number:
    US 8,778,362 B2
    Description:

    Disclosed are mammalian tumor and/or cancer cell conditioned substrate preparations having tumor inhibiting activity. In some embodiments, the mammalian tumor and/or cancer cell conditioned substrate preparations are essentially free of cellular components. These preparations comprise a conditioned heterologous acellular collagenous tissue preparation, and may be prepared using a mammalian extracellular matrix substrate. The conditioned substrates include many different anti-tumor and/or anti…

    Date Issued:
    2014-07-15
    Resource Type
    Patent
  • Inventor(s):
    Mark A. Suckow, William R. Wolter
    Patent Number:
    US 8846059 B2
    Description:

    Compositions suitable for use as ovarian cancer and/or tumor adjuvants in the preparation of ovarian cancer vaccines, particularly those vaccines useful in the treatment of human ovarian cancer, are provided. The ovarian cancer adjuvants described are comprised of an extracellular matrix material, such as small intestinal submucosal (SIS) tissue. The preparations may take the form of sheets, gels, liquids (injectable), tracer, or other solid or semi-solid preparation. Also disclosed are ovari…

    Date Issued:
    2014-09-30
    Resource Type
    Patent
  • Inventor(s):
    Mark A. Suckow, William R. Wolter, Paul J. Hall
    Patent Number:
    US 9220770 B2
    Description:

    Disclosed are vaccines and vaccine adjuvants useful in the treatment and/or prevention of infection and diseases associated with infectious pathogens, such as tetanus, as well as diseases associated with biological toxins. Also provided are methods of preparing an adjuvant and the vaccine containing the adjuvant. Methods are also provided for vaccinating/immunizing an animal against infection and diseases associated with infectious pathogens, such as tetanus, and other diseases associated wit…

    Date Issued:
    2015-12-29
    Resource Type
    Patent
  • Inventor(s):
    Mark A. Suckow, William R. Wolter, Morris Pollard
    Patent Number:
    US 8062646 B2
    Description:

    Compositions comprising a tissue vaccine that include a mixture of heterogeneous tissue obtained from tumors and connective tissues. Vaccines comprising these compositions are also provided, as well as methods of using the vaccines in the treatment and/or inhibition of tumor growth, and particularly prostate tumor growth and cancers. The preparations may be defined as vaccines comprising tumor cells and connective (stromal) tissues derived from xenogeneic animals. Preparations comprising the …

    Date Issued:
    2011-11-22
    Resource Type
    Patent
  • Inventor(s):
    Mark A. Suckow, William R. Wolter
    Patent Number:
    US 8,778,360 B2
    Description:

    Compositions suitable for use as adjuvants in the preparation of vaccines, particularly those vaccines useful in the treatment of cancer, are provided. Methods for inhibiting tumor growth in an animal are also disclosed. Methods for immunizing an animal against cancer, such as prostate cancer, are also described. The adjuvants described are comprised of an extracellular matrix material, such as small intestinal submucosal (SIS) tissue. The preparations may take the form of sheets, gels, liqui…

    Date Issued:
    2014-07-15
    Resource Type
    Patent
  • Inventor(s):
    Mark A. Suckow, William R. Wolter, Valerie Sailes
    Patent Number:
    US 9283266 B2
    Description:

    Disclosed are compositions and pharmaceutical preparations suitable for inhibiting metastasis of a malignant cancer in an animal. Methods for inhibiting and/or eliminating metastasis in an animal are also provided. In some embodiments, the preparations and compositions comprise a whole cell tumor preparation comprising tumor tissue cells and tumor connective tissue stroma. The disclosure also provides methods for preparing the preparations and pharmaceutical preparations. Inhibition of metast…

    Date Issued:
    2016-03-15
    Resource Type
    Patent
  • Inventor(s):
    Mark A. Suckow, William R. Wolter, Paul J. Hall
    Patent Number:
    US 9308252 B2
    Description:

    Disclosed are vaccines and vaccine adjuvants useful in the treatment and/or prevention of infection and diseases associated with infectious pathogens, such as tetanus, as well as diseases associated with biological toxins. Also provided are methods of preparing an adjuvant and the vaccine containing the adjuvant. Methods are also provided for vaccinating/immunizing an animal against infection and diseases associated with infectious pathogens, such as tetanus, and other diseases associated wit…

    Date Issued:
    2016-04-12
    Resource Type
    Patent