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  • Inventor(s):
    Marvin J. Miller, Garrett C. Moraski
    Patent Number:
    US 8362268 B2
    Description:

    Embodiments herein provide compounds and methods of making and using such compounds for prevention and treatment of multidrug resistant bacteria. In particular, embodiments are directed to anti-bacterial agents from benzo[d]heterocyclic scaffolds for prevention and treatment of multidrug resistant bacteria.

    Date Issued:
    2013-01-29
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller, Julia M. Dolence, Manuka Ghosh
    Patent Number:
    US 5783689 B2
    Description:

    5’-O-Acyl-5-fluorouridines and 5’-O-acyl-5-sluorocytidines are prepared by the direct acylation of the 5’-hydroxyl group with amino acids under Mitsunobu conditions and the amino acyl derivatives are coupled with other amino acids or peptides to provide antibacterial and antifungal derivatives of the nucleosides. For example, 5-fluorouridine is acylated at the 5’-hydroxyl group with an amino protected L-valine and the acylation product is deprotected to provide 5’-O-(L-val…

    Date Issued:
    1998-07-21
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Chi-Nung W. Hsiao, Marvin J. Miller
    Patent Number:
    US 4745201 B2
    Description:

    A stereoselective process for chiral intermediates to 1-carbapenum and 1-carbacephalosporins is provided comprising the use of an N-acyl-(4R)-substituted-1,3-thiazolidine-2-thione as a chiral auxiliary in boron enolate mediated aldol condensation with a protected-.beta.-keto ester aldehyde. E.g., benzyl 3,3-(ethylenedioxy)-4-formylbutyrate is condensed with the boron enolate formed with n-butyryl (4R)-methoxycarbonyl-1,3-thiazolidine-2-thione to provide benzyl 3,3-ethylenedioxy-(5R)-hydroxy-6…

    Date Issued:
    1988-05-17
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller
    Patent Number:
    US 4751296 B2
    Description:

    A process for 4-halomethylazetidin-2-ones is provided which comprises mixing in an inert solvent a positive halogen reagent in the presence of a weak base with a .beta.,.gamma.-unsaturated O-acylhydroxamate of the formula ##STR1## wherein R is protected amino, lower alkyl or phenyl substituted lower alkyl, R.sub.2 is a substituent such as lower alkyl which may be substituted by formyl, hydroxy, halogen, etc., and R.sub.1 is alkoxy, benzyloxy, etc. When R is a protected amino group, the proces…

    Date Issued:
    1988-06-14
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller, Matthew A. Williams
    Patent Number:
    US 5051502 B2
    Description:

    1-Carbapenam-2-one-3-carboxylic acid and 1-carba-3-hydroxy-3-cephem-4-carboxylic acid and esters thereof are provided by a process comprising a rhodium C.sub.2 -C.sub.10 carboxylate catalyzed cyclization of an ester of a 4-(1-alkoxy- or 1-substituted alkxoy)-2-oxo-4-azetidinyl)-.alpha.-diazo-.beta.-ketobutyric acid and an ester of a 5-(1-alkoxy- or 1-substituted alkoxy-2-oxo-4-azetidinyl)-.alpha.-diazo-.beta.-ketovaleric acid respectively. The process is carried out in an inert organic solven…

    Date Issued:
    1991-09-24
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller
    Patent Number:
    US 4992544 B2
    Description:

    Monocyclic .beta.-lactam compounds represented by the formula ##STR1## wherein R.sub.1 is H, NH.sub.2, acylamino, C.sub.1 -C.sub.4 alkyl, etc.; R.sub.2 is e.g. C.sub.1 -C.sub.4 alkyl, hydroxyalkyl, aminoalkyl, carboxy, esterified carboxy, esterified carboxyalkyl, or carboxyalkyl; and R.sub.3 is hydrogen, benzyl, substituted benzyl, pivaloyl, –SO.sub.3 M, or –P(C.dbd.O)(OM’)2; are obtained by the cyclization of an O-substituted hydroxamate of a .beta.-substituted alkylcarboxylic acid. Fo…

    Date Issued:
    1991-02-12
    Record Visibility:
    Public
    Resource Type
    Patent