College of Science
Search criteria:
List of files deposited in CurateND that match your search criteria
-
- Inventor(s):
- Shahriar Mobashery, Dusan Hesek, Mayland Chang
- Patent Number:
- US 8859620 B2
- Description:
The invention provides antimicrobial compounds and compositions, and methods of using them. The compounds and compositions include, for example, a compound of any one of Formulas I-X. The invention further provides methods of preparing the compounds, and useful intermediates for their preparation. The compounds can possess highly specific and selective activity, such as antibacterial activity and/or enzymatic inhibitory activity. Accordingly, the compounds and compositions can be used to trea…
- Date Issued:
- 2014-10-14
-
- Inventor(s):
- Shahriar Mobashery, Peter I. O'Daniel, Mayland Chang
- Patent Number:
- US 9045442 B2
- Description:
Embodiments of the present invention provide novel antibacterials that target penicillin-binding proteins or other important cellular targets. Methods for inhibiting growth (reproduction, etc.) of bacteria using compounds described herein are also provided. Various embodiments exhibit activity against gram positive bacteria, such as certain strains of Entercoccus and Staphylococcus aureus.
- Date Issued:
- 2015-06-02
-
3
Patent
- Inventor(s):
- Mayland Chang, Shahriar Mobashery, Mijoon Lee
- Patent Number:
- US 9321754 B2
- Description:
The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The disease, disorder, or condition can include, for example, stroke, neurological disorders, or ophthalmological disorders. The treatment can include administering a compound or composition described herein, thereby providing a prodrug compound that metabolizes to an active MMP inhibitor in vivo. The MMP inhibition can be …
- Date Issued:
- 2016-04-26
-
- Inventor(s):
- Mijoon Lee, Masahiro Ikejiri, Mayland Chang, Rafael Fridman, Shahriar Mobashery
- Patent Number:
- US 7928127 B2
- Description:
The present invention provides novel compounds of formulas I-IX, as described herein. Also provided are compositions of compounds of formulas I-IX, methods of making compounds of formulas I-IX, and methods of using compounds of formulas I-IX. The compounds of the invention can be used to inhibit matrix metalloproteinases, and are useful to treat conditions and diseases associated therewith.
- Date Issued:
- 2011-04-19
-
- Inventor(s):
- Mijoon Lee, Masahiro Ikejiri, Mayland Chang, Rafael Fridman, Shahriar Mobashery
- Patent Number:
- US 8093287 B2
- Description:
The present invention provides novel compounds of formulas I-IX, as described herein. Also provided are compositions of compounds of formulas I-IX, methods of making compounds of formulas I-IX, and methods of using compounds of formulas I-IX. The compounds of the invention can be used to inhibit matrix metalloproteinases, and are useful to treat conditions and diseases associated therewith.
- Date Issued:
- 2012-01-10
-
6
Patent
- Inventor(s):
- Mayland Chang, Shahriar Mobashery, Mijoon Lee
- Patent Number:
- US 8937151 B2
- Description:
The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The disease, disorder, or condition can include, for example, stroke, neurological disorders, or ophthalmological disorders. The treatment can include administering a compound or composition described herein, thereby providing a prodrug compound that metabolizes to an active MMP inhibitor in vivo. The MMP inhibition can be …
- Date Issued:
- 2015-01-20
-
- Inventor(s):
- Mayland Chang, Shahriar Mobashery
- Patent Number:
- US 9604957 B2
- Description:
The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The compounds can be selective MMP inhibitors, for example, selective inhibitors of MMP-2, MMP-9, and/or MMP-14. The disease, disorder, or condition can include, for example, stroke, neurological disorders, ophthalmological disorders, or wounds, such as chronic wounds or diabetic wounds.
- Date Issued:
- 2017-03-28
-
8
Patent
- Inventor(s):
- Mayland Chang, Shahriar Mobashery, Renee Bouley
- Patent Number:
- US 9,776,975 B2
- Description:
A new class of antibiotics effective against methicillin-resistant Staphylococcus aureus (MRSA) is disclosed. Compounds of this class can impair cell-wall biosynthesis by binding to both the allosteric and the catalytic domains of penicillin-binding protein (PBP) 2a. This class of antibiotics holds promise in reversing obsolescence of staphylococcal PBPs as important targets for antibiotics. Embodiments of the invention thus provide novel antibacterial compounds that target penicillin-binding…
- Date Issued:
- 2017-10-03
-
9
Patent
- Inventor(s):
- Mayland Chang, Shahriar Mobashery, Mijoon Lee
- Patent Number:
- US 9867805 B2
- Description:
The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The disease, disorder, or condition can include, for example, stroke, neurological disorders, or ophthalmological disorders. The treatment can include administering a compound or composition described herein, thereby providing a prodrug compound that metabolizes to an active MMP inhibitor in vivo. The MMP inhibition can be …
- Date Issued:
- 2018-01-16
-
- Inventor(s):
- Mayland Chang, Shahriar Mobashery
- Patent Number:
- US 9951035 B2
- Description:
The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The compounds can be selective MMP inhibitors, for example, selective inhibitors of MMP-2, MMP-9, and/or MMP-14. The disease, disorder, or condition can include, for example, stroke, neurological disorders, ophthalmological disorders, or wounds, such as chronic wounds or diabetic wounds.
- Date Issued:
- 2018-04-24