College of Science
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- Inventor(s):
- Olaf G. Wiest, Paul Helquist, Frederick R. Maxfield
- Patent Number:
- US 9333222 B2
- Description:
Embodiments herein relate to the field of lysosomal storage disorders, and, more specifically, to methods of treating lysosomal storage disorders such as Niemann-Pick type C disease, for instance with inhibitors of histone deacetylases, particularly inhibitors of class 1 histone deacetylases. In various embodiments, methods of treating Niemann-Pick type C disease with inhibitors of class 1 histone deacetylases are described.
- Date Issued:
- May 10, 2016
- Record Visibility:
- Public
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- Inventor(s):
- Marvin J. Miller
- Patent Number:
- US 4595532 B2
- Description:
N-Mono or N-disubstituted methyl-2-azetidinones are provided via cyclization of .beta.-hydroxy or .beta.-halo substituted acid sec-amides wherein the amide nitrogen is substituted with a mono- or di-substituted methyl group having activating substituents. Cyclization of .beta.-hydroxy acid amides is mediated by triphenylphosphine-dialkylazodicarboxylate while cyclization of .beta.-halo acid amides is mediated by strong bases e.g. lithium dialkylamides. E.g. Diethyl amino-protected L-serylamin…
- Date Issued:
- 1986-06-17
- Record Visibility:
- Public
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- Inventor(s):
- Bradley D. Smith, Arunkumar Easwaran
- Patent Number:
- US 8273875 B2
- Description:
Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to novel near-infrared dyes that are photostable and resistant to quenching. The dyes belong to a novel family of squaraine rotaxanes, and they are particularly well-suited for use in biological applications. Also disclosed are methods of synthesizing the dyes and methods of using the dyes.
- Date Issued:
- 2012-09-25
- Record Visibility:
- Public
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4
Patent
- Inventor(s):
- Marvin J. Miller, Yanping Xu
- Patent Number:
- US 6310058 B2
- Description:
Compounds represented by the formula [1] ##STR1## R.sub.1 is H or a substituent; R.sub.2 and R.sub.3 are C.sub.1 -C.sub.3 alkyl; R.sub.4 is siderophore group e.g. CH.sub.3 –(CH.sub.2).sub.n –C(O)–N(OH)–(CH.sub.2).sub.m – with n=10-22, m=2-6; X is O, S, or NH; X.sub.1 is O or NH; Y is H or alkyl; Z is H or substituted amino, e.g., t-BocNH or CbzNH, and r is 2-4; are useful in the method provided for treating tuberculosis. [1] is prepared by coupling [7], wherein HX.sub.1 is HO– or H.sub….
- Date Issued:
- 2001-10-30
- Record Visibility:
- Public
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- Inventor(s):
- Marvin J. Miller
- Patent Number:
- US 4675399 B2
- Description:
Process for N-acyloxy or sulfooxy 2-azetidinones comprising O-acylation of a .beta.-hydroxy or .beta.-halo hydroxamic acid, and cyclizing the O-acylhydroxamate with TPP-CCl.sub.4 -TEA or with TPP-dialkylazodicarboxylate to the N-acyloxy-2-azetidinone. Solvolysis of the acyl group provides an N-hydroxy-2-azetidinone. e.g., N-Cbz-L-serine is converted to the O-acetyl hydroxamate, cyclized and solvolyzed to N-hydroxy-3-(Cbz-amino)-2-azetidinone. The N-hydroxy-2-azetidinones are useful intermedia…
- Date Issued:
- 1987-06-23
- Record Visibility:
- Public
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- Inventor(s):
- John G. Duman
- Patent Number:
- US 5627051 B2
- Description:
The present invention is directed to nucleic acid sequences encoding Dendroides canadensis thermal hysteresis proteins. The THPs of Dendroides have significantly greater thermal hysteresis activity than any other known anti-freeze protein. The thermal hysteresis activity of the purified THPs can be further enhanced by combining the THPs with various “activating” compounds.
- Date Issued:
- 1997-05-06
- Record Visibility:
- Public
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- Inventor(s):
- Marvin J. Miller
- Patent Number:
- US 5266468 B2
- Description:
.beta.-Hydroxy-.alpha.-amino acids are obtained via serine hydroxymethyltransferase catalyzed condensation of aldehydes with glycine. The predominant product with most aldehydes is the L-erythro diastereomer. For example, succinic semialdehyde methylester is condensed with glycine in the process to provide L-erythro .alpha.-amino hydroxy adipic acid mono methyl ester.
- Date Issued:
- 1993-11-30
- Record Visibility:
- Public
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8
Patent
- Inventor(s):
- John H. Adams, Malcolm J. Fraser, Bharath Balu, Douglas A. Shoue
- Patent Number:
- US 7932088 B2
- Description:
The present invention provides molecular methods for efficiently transforming the genome of common disease-transmitting parasites, such as Plasmodium falciparum. The transformation efficiencies are improved up to 100 times over those conventionally known. The methods provide high saturation of the target parasite genome, of 50% or greater, and target non-specifically TTAA-rich sites in the parasite genome. The invention also discloses a model that may be used to functionally annotate the geno…
- Date Issued:
- 2011-04-26
- Record Visibility:
- Public
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- Inventor(s):
- Malcolm J. Fraser, Xu Li
- Patent Number:
- US 6962810 B2
- Description:
More efficient transfer of genes into host cells or embryos to transform the cells or embryos is facilitated by transposition vectors using the minimal amount of nucleotide sequences in the transposon piggyBac required for gene transfer. The transformed cells or embryos may be developed into transgenic organisms.
- Date Issued:
- 2005-11-08
- Record Visibility:
- Public
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- Inventor(s):
- Gaetano Francis D'Alelio
- Patent Number:
- US 3639348 B2
- Description:
The copolymers disclosed herein are of propargyl acrylate and methacrylate. Polymerization of propargyl acrylate and methacrylate in free radical systems generally results in crosslinked or gelled products since the free radicals will activate polymerization through the acetylenic as well as through the acrylic unsaturation. Therefore the copolymers are advantageously prepared byanionic polymerization. The comonomers are those which are copolymerizable with acrylates and methacrylates inanion…
- Date Issued:
- 1972-02-01
- Record Visibility:
- Public
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- Inventor(s):
- Gaetano Francis D'Alelio
- Patent Number:
- US 4058505 B2
- Description:
Aromatic polyimides with amine end groups are chain-extended (molecular weight increased) by reacting them with aromatic di- or tri- anhydrides. The reaction can either be at a temperature above the melting point of the reactants or in solvents for the reactants. The polyimides can be shaped and formed prior to chain-extending.
- Date Issued:
- 1977-11-15
- Record Visibility:
- Public
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- Inventor(s):
- Chi-Nung W. Hsiao, Marvin J. Miller
- Patent Number:
- US 4845229 B2
- Description:
A stereoselective process for chiral intermediates to 1-carbapenem and 1-carbacephalosporins is provided comprising the use of an N-acyl-(4R)-substituted-1,3-thiazolidine-2-thione as a chiral auxiliary in boron enolate mediated aldol condensation with a protected-.beta.-keto ester aldehyde. E.g., benzyl 3,3-(ethylenedioxy)-4-formylbutyrate is condensed with the boron enolate formed with n-butyryl (4R)-methoxycarbonyl-1,3-thiazolidine-2-thione to provide benzyl 3,3-ethylenedioxy-(5R)-hydroxy-6…
- Date Issued:
- 1989-07-04
- Record Visibility:
- Public