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  • Inventor(s):
    Kent Walters, John G. Duman, Anthony S. Serianni
    Patent Number:
    US 8604002 B1
    Description:

    The invention provides an antifreeze glycolipid compounds and composition comprising a polysaccharide moiety of Formula I: missing image wherein D-Manp represents a D-mannopyranose moiety, D-Xylp represents a D-xylopyranose moiety, and n is about 5 to about 70; and one or more lipid moieties covalently linked to the polysaccharide moiety of Formula I or electrostatically associated with the polysaccharide moiety of Formula I. The antifreeze glycolipid compounds and compositions can be u…

    Date Issued:
    2013-12-10
    Resource Type
    Patent
  • Inventor(s):
    Mark A. Suckow, William R. Wolter
    Patent Number:
    US 8802113 B2
    Description:

    Compositions suitable for use as adjuvants in the preparation of vaccines, particularly those vaccines useful in the treatment of cancer, are provided. Methods for inhibiting tumor growth in an animal are also disclosed. Methods for immunizing an animal against cancer, such as prostate cancer, are also described. The adjuvants described are comprised of an extracellular matrix material, such as small intestinal submucosal (SIS) tissue. The preparations may take the form of sheets, gels, liqui…

    Date Issued:
    2014-08-12
    Resource Type
    Patent
  • Inventor(s):
    Shahriar Mobashery, Dusan Hesek, Mayland Chang
    Patent Number:
    US 8859620 B2
    Description:

    The invention provides antimicrobial compounds and compositions, and methods of using them. The compounds and compositions include, for example, a compound of any one of Formulas I-X. The invention further provides methods of preparing the compounds, and useful intermediates for their preparation. The compounds can possess highly specific and selective activity, such as antibacterial activity and/or enzymatic inhibitory activity. Accordingly, the compounds and compositions can be used to trea…

    Date Issued:
    2014-10-14
    Resource Type
    Patent
  • Inventor(s):
    Mark A. Suckow, Michael C. Hiles
    Patent Number:
    US 8,778,362 B2
    Description:

    Disclosed are mammalian tumor and/or cancer cell conditioned substrate preparations having tumor inhibiting activity. In some embodiments, the mammalian tumor and/or cancer cell conditioned substrate preparations are essentially free of cellular components. These preparations comprise a conditioned heterologous acellular collagenous tissue preparation, and may be prepared using a mammalian extracellular matrix substrate. The conditioned substrates include many different anti-tumor and/or anti…

    Date Issued:
    2014-07-15
    Resource Type
    Patent
  • Inventor(s):
    Mark A. Suckow, William R. Wolter
    Patent Number:
    US 8846059 B2
    Description:

    Compositions suitable for use as ovarian cancer and/or tumor adjuvants in the preparation of ovarian cancer vaccines, particularly those vaccines useful in the treatment of human ovarian cancer, are provided. The ovarian cancer adjuvants described are comprised of an extracellular matrix material, such as small intestinal submucosal (SIS) tissue. The preparations may take the form of sheets, gels, liquids (injectable), tracer, or other solid or semi-solid preparation. Also disclosed are ovari…

    Date Issued:
    2014-09-30
    Resource Type
    Patent
  • Inventor(s):
    Mark A. Suckow, William R. Wolter, Paul J. Hall
    Patent Number:
    US 9220770 B2
    Description:

    Disclosed are vaccines and vaccine adjuvants useful in the treatment and/or prevention of infection and diseases associated with infectious pathogens, such as tetanus, as well as diseases associated with biological toxins. Also provided are methods of preparing an adjuvant and the vaccine containing the adjuvant. Methods are also provided for vaccinating/immunizing an animal against infection and diseases associated with infectious pathogens, such as tetanus, and other diseases associated wit…

    Date Issued:
    2015-12-29
    Resource Type
    Patent
  • Inventor(s):
    Shahriar Mobashery, Peter I. O'Daniel, Mayland Chang
    Patent Number:
    US 9045442 B2
    Description:

    Embodiments of the present invention provide novel antibacterials that target penicillin-binding proteins or other important cellular targets. Methods for inhibiting growth (reproduction, etc.) of bacteria using compounds described herein are also provided. Various embodiments exhibit activity against gram positive bacteria, such as certain strains of Entercoccus and Staphylococcus aureus.

    Date Issued:
    2015-06-02
    Resource Type
    Patent
  • Inventor(s):
    Boldizsár Jankó, Cynthia Reichhardt, Charles Reichhardt, Dipanjan Ray
    Patent Number:
    US 9082923 B2
    Description:

    Disclosed is a method and apparatus for strongly enhancing vortex pinning by conformal crystal arrays. The conformal crystal array is constructed by a conformal transformation of a hexagonal lattice, producing a non-uniform structure with a gradient where the local six-fold coordination of the pinning sites is preserved, and with an arching effect. The conformal pinning arrays produce significantly enhanced vortex pinning over a much wider range of field than that found for other vortex pinni…

    Date Issued:
    2015-07-14
    Resource Type
    Patent
  • Inventor(s):
    Mayland Chang, Shahriar Mobashery, Mijoon Lee
    Patent Number:
    US 9321754 B2
    Description:

    The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The disease, disorder, or condition can include, for example, stroke, neurological disorders, or ophthalmological disorders. The treatment can include administering a compound or composition described herein, thereby providing a prodrug compound that metabolizes to an active MMP inhibitor in vivo. The MMP inhibition can be …

    Date Issued:
    2016-04-26
    Resource Type
    Patent
  • Inventor(s):
    Steven Ruggiero, Carol Tanner
    Patent Number:
    US 9366612 B2
    Description:

    An apparatus for obtaining suspended particle information includes an optical array to divide light to a first path and a second path, a platform to orient a first and second container with either the first or second path, and a first and second photodetector to receive at least a direct illuminating component of the light of the first and second path after said light penetrates through the first and second container. A detector interface receives transmission signals from the first and secon…

    Date Issued:
    2016-06-14
    Resource Type
    Patent
  • Inventor(s):
    Olaf G. Wiest, Frederick R. Maxfield, Paul Helquist
    Patent Number:
    US 9333222 B2
    Description:

    Embodiments herein relate to the field of lysosomal storage disorders, and, more specifically, to methods of treating lysosomal storage disorders such as Niemann-Pick type C disease, for instance with inhibitors of histone deacetylases, particularly inhibitors of class 1 histone deacetylases. In various embodiments, methods of treating Niemann-Pick type C disease with inhibitors of class 1 histone deacetylases are described.

    Date Issued:
    2016-05-10
    Resource Type
    Patent
  • Inventor(s):
    Crislyn D'Souza-Schorey, James W. Clancy, Vandhana Muralidharan-Chari
    Patent Number:
    US 9329188 B2
    Description:

    The present application relates to the isolation and analysis of populations of microvesicles and the identification of invasive microvesicles in the populations such as populations of microvesicles that are shed by tumor cells. Invasive microvesicles from tumor cells contain a variety of specific proteins, such as ARF6.

    Date Issued:
    2016-05-03
    Resource Type
    Patent