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  • Inventor(s):
    Mark A. Suckow, William R. Wolter, Paul J. Hall
    Patent Number:
    US 9220770 B2
    Description:

    Disclosed are vaccines and vaccine adjuvants useful in the treatment and/or prevention of infection and diseases associated with infectious pathogens, such as tetanus, as well as diseases associated with biological toxins. Also provided are methods of preparing an adjuvant and the vaccine containing the adjuvant. Methods are also provided for vaccinating/immunizing an animal against infection and diseases associated with infectious pathogens, such as tetanus, and other diseases associated wit…

    Date Issued:
    2015-12-29
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Steven Ruggiero, Carol Tanner
    Patent Number:
    US 9366612 B2
    Description:

    An apparatus for obtaining suspended particle information includes an optical array to divide light to a first path and a second path, a platform to orient a first and second container with either the first or second path, and a first and second photodetector to receive at least a direct illuminating component of the light of the first and second path after said light penetrates through the first and second container. A detector interface receives transmission signals from the first and secon…

    Date Issued:
    2016-06-14
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Shahriar Mobashery, Peter I. O'Daniel, Mayland Chang
    Patent Number:
    US 9045442 B2
    Description:

    Embodiments of the present invention provide novel antibacterials that target penicillin-binding proteins or other important cellular targets. Methods for inhibiting growth (reproduction, etc.) of bacteria using compounds described herein are also provided. Various embodiments exhibit activity against gram positive bacteria, such as certain strains of Entercoccus and Staphylococcus aureus.

    Date Issued:
    2015-06-02
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Boldizsár Jankó, Cynthia Reichhardt, Charles Reichhardt, Dipanjan Ray
    Patent Number:
    US 9082923 B2
    Description:

    Disclosed is a method and apparatus for strongly enhancing vortex pinning by conformal crystal arrays. The conformal crystal array is constructed by a conformal transformation of a hexagonal lattice, producing a non-uniform structure with a gradient where the local six-fold coordination of the pinning sites is preserved, and with an arching effect. The conformal pinning arrays produce significantly enhanced vortex pinning over a much wider range of field than that found for other vortex pinni…

    Date Issued:
    2015-07-14
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Mayland Chang, Shahriar Mobashery, Mijoon Lee
    Patent Number:
    US 9321754 B2
    Description:

    The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The disease, disorder, or condition can include, for example, stroke, neurological disorders, or ophthalmological disorders. The treatment can include administering a compound or composition described herein, thereby providing a prodrug compound that metabolizes to an active MMP inhibitor in vivo. The MMP inhibition can be …

    Date Issued:
    2016-04-26
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Julius A. Nieuwland
    Patent Number:
    US 1811959
    Description:

    This invention relates to a process for controlling acetylene reactions and for bringing about the reaction of acetylene with other substances. More particularly it relates to the use of cuprous chloride in acetylene re-actions as a catalyst.

    (See also http://www.invent.org/honor/inductees/inductee-detail/?IID=111)

    Date Issued:
    1931-06-30
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Mayland Chang, Shahriar Mobashery, Mijoon Lee
    Patent Number:
    US 8937151 B2
    Description:

    The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The disease, disorder, or condition can include, for example, stroke, neurological disorders, or ophthalmological disorders. The treatment can include administering a compound or composition described herein, thereby providing a prodrug compound that metabolizes to an active MMP inhibitor in vivo. The MMP inhibition can be …

    Date Issued:
    2015-01-20
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller, Garrett C. Moraski, Jonathan Stefely
    Patent Number:
    US 8729270 B2
    Description:

    Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to anti-cancer compounds, synthesis thereof, and methods of using same. Disclosed herein are various heterocyclic compounds and methods of using the novel anti-cancer compounds to inhibit the growth of a cancer cell, for instance a leukemia, non-small cell lung, central nervous system (CNS), skin, ovarian, renal, prostate, breast, or colon cancer cell. Other embodiments include methods of treating cancer in…

    Date Issued:
    2014-05-20
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Alexander Mukasyan, Khachatur Manukyan
    Patent Number:
    US 9580323 B2
    Description:

    The invention provides methods for the combustion synthesis (CS) of graphene by a novel exothermic self-sustained reaction between a refractory ceramic compound and a carbon-containing polymer under an inert gas atmosphere. The synthesis of graphene was confirmed by both transmission electron microscopy and Raman spectroscopy. The graphene produced has very low (<1 wt. %) oxygen content. Fluorocarbon gases released due to decomposition of the carbon-containing polymer in the combustion wav…

    Date Issued:
    2017-02-28
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    James McGivney, Guijie Zhu, Norman Dovichi
    Patent Number:
    US 9159537 B2
    Description:

    Described herein is a method and system for on-line coupling of capillary isoelectric focusing (cIEF) to high-resolution mass spectrometry in which a sheath flow buffer comprising polar organic solvent and organic acid is used as both an immobilization solution for (cIEF) and an ionization solution for electrospray ionization (ESI).

    Date Issued:
    2015-10-13
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Robert M. Williams, James E. Bradner, Albert Bowers, Tenaya Newkirk, Olaf G. Wiest
    Patent Number:
    US 9186402 B2
    Description:

    Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.

    Date Issued:
    2015-11-17
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Richard E. Taylor
    Patent Number:
    US 8865761 B1
    Description:

    The invention provides novel compounds of Formulas (I)-(IV), as described herein. Also provided are compositions of these compounds, method of making the compounds, and methods of using the compounds. The compounds can be used to regulate cholesterol homeostasis and to treat conditions and diseases associated with cholesterol homeostasis, including lysosomal lipid storage disorders such as Niemann-Pick Disease type C.

    Date Issued:
    2014-10-21
    Record Visibility:
    Public
    Resource Type
    Patent