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  • Author(s):
    Tsuyoshi Tokusumi, Yumiko Tokusumi, Robert A. Schulz
    Abstract:

    Hedgehog (Hh) pathway signaling is crucial for the maintenance of blood cell progenitors in thelymph gland hematopoietic organ present in Drosophila third instar larvae. Previous studies fromour lab have likewise shown the importance of the mir-7 and bag of marbles (bam) genes in main-taining the progenitor state. Thus, we sought to investigate a possible interaction between the Hhpathway and mir-7/bam in the prohemocyte population within this hematopoietic tissue. Gain offunction mir-7 was a…

    Date Published:
    2018-04
  • Author(s):
    Scott Shaw, Wenqi Liu, Cesar Fernando Azael Gomez Duran, Cynthia Schreiber, Maria de Lourdes Betancourt Mendiola, Canjai Zhai, Felicia Roland, Simon Padanilam, Bradley Smith
    Abstract:

    New fluorescent molecular probes, which can selectively target specific cell surface receptors, are needed for microscopy, in vivo imaging, and image guided surgery. The preparation of multivalent probes using standard synthetic chemistry can be a laborious process due to low reaction yields caused by steric effects. In this study, fluorescent molecular probes were prepared by a programmed non‐covalent pre‐assembly process that used a near‐infrared fluorescent squaraine dye to thread a macroc…

    Date Published:
    2018