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  • Inventor(s):
    John H. Adams, Malcolm J. Fraser, Bharath Balu, Douglas A. Shoue
    Patent Number:
    US 7932088 B2
    Description:

    The present invention provides molecular methods for efficiently transforming the genome of common disease-transmitting parasites, such as Plasmodium falciparum. The transformation efficiencies are improved up to 100 times over those conventionally known. The methods provide high saturation of the target parasite genome, of 50% or greater, and target non-specifically TTAA-rich sites in the parasite genome. The invention also discloses a model that may be used to functionally annotate the geno…

    Date Issued:
    2011-04-26
    Resource Type
    Patent
  • Inventor(s):
    Richard E. Taylor, Yue Chen
    Patent Number:
    US 6900331 B2
    Description:

    The present invention provides the following new compounds: ®-C14-methyl-epothilone B, (S)-C14-methyl-epothilone B, (S)-C14-methyl-epothilone D, and ®-C14-methyl-epothilone D and methods for synthesizing these compounds.

    Date Issued:
    2005-05-31
    Resource Type
    Patent
  • Inventor(s):
    Paul Helquist, Joakim Loefstedt
    Patent Number:
    US 7235688 B2
    Description:

    A process for preparing unsaturated esters useful as intermediates for HDAC inhibitors, by reacting an aldehyde or ketone having the following formula I: ##STR00001## wherein R.sub.1 is an aromatic group or a combined aliphatic and aromatic group; X is –O–, –S–, –COO–, –OOC–, –CONR.sub.7–, or –R.sub.7NCO–; L.sub.1 an aliphatic linking group, an aromatic linking group, or a combined aliphatic and aromatic linking group; R.sub.2 and R.sub.3 are each independently hydrogen, a hydroxy…

    Date Issued:
    2007-06-26
    Resource Type
    Patent
  • Inventor(s):
    Paul D. Shirk, Malcolm J. Fraser, Teresa A. Elick, Omaththage P. Perera
    Patent Number:
    US 6551825 B2
    Description:

    The present invention is directed to nucleic acid and amino acid sequences for transformation constructs containing piggyBac or tagalong transposable elements. These constructs allow for the precise excision and insertion of heterologous DNA into a host cell.

    Date Issued:
    2003-04-22
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller
    Patent Number:
    US 4820815 B2
    Description:

    The invention provides azetidinones of the formula ##STR1## where R.sub.4 is hydrogen, amino or protected amino; R.sup.0 is H when R.sub.4 is amino or protected amino, or C.sub.1 -C.sub.4 alkyl when R.sub.4 is H; R.sub.1 is H, CH.sub.3, –CH.sub.2 –.sub.n Y where Y is OH, protected OH, –CH.sub.2 OH, protected –CH.sub.2 OH, halogen, COOH or protected COOH; n is 1 or 2; –CH.sub.2 –C(O)SR.sub.1 ‘ where R.sub.1 ’ is e.g., C.sub.1 -C.sub.4 alkyl; R.sub.2 is H or protecting group and R…

    Date Issued:
    1989-04-11
    Resource Type
    Patent
  • Inventor(s):
    Chi-Nung W. Hsiao, Marvin J. Miller
    Patent Number:
    US 4845229 B2
    Description:

    A stereoselective process for chiral intermediates to 1-carbapenem and 1-carbacephalosporins is provided comprising the use of an N-acyl-(4R)-substituted-1,3-thiazolidine-2-thione as a chiral auxiliary in boron enolate mediated aldol condensation with a protected-.beta.-keto ester aldehyde. E.g., benzyl 3,3-(ethylenedioxy)-4-formylbutyrate is condensed with the boron enolate formed with n-butyryl (4R)-methoxycarbonyl-1,3-thiazolidine-2-thione to provide benzyl 3,3-ethylenedioxy-(5R)-hydroxy-6…

    Date Issued:
    1989-07-04
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller, Jingdan Hu
    Patent Number:
    US 6403623 B2
    Description:

    Method for treating tuberculosis with 2-(2-substituted-phenyl)-2-oxazolines and related 5-membered heterocycles represented by the formula ##STR1## Y.sub.1 is e.g. an ester or amide forming group, and X is O, S, or NH; and pharmaceutically acceptable formulations useful therein are provided. A preferred method comprises administering (S)-benzyl2-[2-(benzyloxy)phenyl]-2-oxazoline-4-carboxylate in a suitable formulation. The compounds of the above formula are prepared by known methods, e.g. the…

    Date Issued:
    2002-06-11
    Resource Type
    Patent
  • Inventor(s):
    Gaetano Francis D'Alelio
    Patent Number:
    US 4118377 B2
    Description:

    Processes for increasing the molecular weight of bis-maleimides are provided. The bis-maleimides are reacted with certain cyclic dienes to form reversible adducts. These adducts, upon elimination of the cyclic diene, yield an extension of the bis-maleimides to higher molecular weight polymers, ultimately to thermally stable, infusible polymers. The process can be interrupted to yield tractable polymers which are also convertible to cross-linked, infusible products. Modifications of the proces…

    Date Issued:
    1978-10-03
    Resource Type
    Patent
  • Inventor(s):
    Min Teng, Marvin J. Miller
    Patent Number:
    US 5750681 B2
    Description:

    Bicyclic .beta.-lactams comprising a 5- or 6-membered lactone or lactam ring are obtained in a process comprising a base induced intramolecular cyclization of a 4-substututed .beta.-lactam having a leaving group in the 1-position. An intramolecular nucleophile transfer reaction is proposed as the operative mechanism and the bicyclic .beta.-lactams are obtained in the required stereochemical form for biological activity. The compounds provided are useful intermediates for the preparation of an…

    Date Issued:
    1998-05-12
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller
    Patent Number:
    US 4595532 B2
    Description:

    N-Mono or N-disubstituted methyl-2-azetidinones are provided via cyclization of .beta.-hydroxy or .beta.-halo substituted acid sec-amides wherein the amide nitrogen is substituted with a mono- or di-substituted methyl group having activating substituents. Cyclization of .beta.-hydroxy acid amides is mediated by triphenylphosphine-dialkylazodicarboxylate while cyclization of .beta.-halo acid amides is mediated by strong bases e.g. lithium dialkylamides. E.g. Diethyl amino-protected L-serylamin…

    Date Issued:
    1986-06-17
    Resource Type
    Patent
  • Inventor(s):
    Gaetano Francis D'Alelio
    Patent Number:
    US 4058505 B2
    Description:

    Aromatic polyimides with amine end groups are chain-extended (molecular weight increased) by reacting them with aromatic di- or tri- anhydrides. The reaction can either be at a temperature above the melting point of the reactants or in solvents for the reactants. The polyimides can be shaped and formed prior to chain-extending.

    Date Issued:
    1977-11-15
    Resource Type
    Patent
  • Inventor(s):
    John G. Duman
    Patent Number:
    US 5633451 B2
    Description:

    The present invention is directed to transgenic plants having nucleic acid sequences encoding Dendroides canadensis thermal hysteresis proteins. The THPs of Dendroides have significantly greater thermal hysteresis activity than any other known anti-freeze protein. The thermal hysteresis activity of the purified THPs can be further enhanced by combining the THPs with various “activating” compounds.

    Date Issued:
    1997-05-27
    Resource Type
    Patent