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  • Inventor(s):
    Gaetano Francis D'Alelio
    Patent Number:
    US 3562231 B2
    Description:

    The process disclosed herein is the bromination of polymers of propargyl methacrylate and the brominated products produced thereby. Propargyl methacrylate has a terminal acetylenic group which upon bromination gives anethylenic dibromo derivative which is hydrolytically stable. In comparison the derivative obtained upon dibromination of a polymer of allyl methacrylate gives dibromopropyl methacrylate repeating units whereas the dibromonation of propargyl methacrylate gives dibromoallyl methac…

    Date Issued:
    1971-02-09
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Gaetano Francis D'Alelio
    Patent Number:
    US 3890272 B2
    Description:

    Processes for preparing polyimides from bis-maleimides are provided. In these processes, a bis-maleimide is polymerized in the presence of a catalytic amount (usually about 0.01 to 5% by weight of the bis-maleimide) of an alkali metal salt of a Bronsted acid. Preferably, the polymerization is also conducted in the presence of a small amount (usually 0.01 to 5% by weight of the bis-maleimide) of an activator for the catalyst. The activator is an aprotic organic compound having a dielectric con…

    Date Issued:
    1975-06-17
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Philip C. Trexler
    Patent Number:
    US 3016284 B2
    Description:

    This invention relates to a sterile container for introducing material into apparatus having a controlled atmosphere. The invention finds particular utility for use in connection with apparatus of the character disclosed in my copending patent application for Isolator Structure, Serial No. 656,396, filed .May 1, 1957.

    Date Issued:
    1962-01-09
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Ralph B. Davis
    Patent Number:
    US 3156704 B2
    Description:

    This invention relates to new chemical compounds, and more specifically arylcyanomethylene quinone oxirnes and their derivatives, and to methods for preparing the same.

    Date Issued:
    1964-11-10
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller, Garrett C. Moraski, Jonathan Stefely
    Patent Number:
    US 8268874 B2
    Description:

    Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to anti-cancer compounds, synthesis thereof, and methods of using same. Disclosed herein are various heterocyclic compounds and methods of using the novel anti-cancer compounds to inhibit the growth of a cancer cell, for instance a leukemia, non-small cell lung, central nervous system (CNS), skin, ovarian, renal, prostate, breast, or colon cancer cell. Other embodiments include methods of treating cancer in…

    Date Issued:
    2012-09-18
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Gaetano Francis D'Alelio
    Patent Number:
    US 3886119 B2
    Description:

    Epoxidized aromatic polyimides and processes for their preparation are provided. The epoxidized polyimides are prepared by reacting a diamine of the formula ##SPC1## Wherein Ar is a divalent aromatic organic radical, Ar’ is a tetravalent aromatic organic radical and n is a positive integer of at least 1, With 1 to 4 moles of an epoxy compound (such as epichlorohydrin) of the formula ##SPC2## Wherein X is halogen and R’ is hydrogen or a hydrocarbon radical of 1 to 6 atoms. The reaction…

    Date Issued:
    1975-05-27
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Gaetano Francis D'Alelio
    Patent Number:
    US 3562230 B2
    Description:

    The process disclosed herein involves the bromination of copolymers of non-terminal acetylenic methacrylates and the brominated products produced thereby. Acetylenic methacrylate polymers upon dibromination of the acetylene group give ethylenic dibromo derivatives which are hydrolytically stable. In comparison the derivative obtained upon dibromination of a polymer of allyl methacrylate has dibromopropyl methacrylate repeating units which are susceptible to hydrolysis of the bromine. Thus whe…

    Date Issued:
    1971-02-09
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Crislyn D'Souza-Schorey, James W. Clancy, Vandhana Muralidharan-Chari
    Patent Number:
    US 8420334 B2
    Description:

    The present application relates to the isolation and analysis of populations of microvesicles, such as populations of microvesicles that are shed by tumor cells and contain the protein ARF6. Invasive microvesicles from tumor cells contain a variety of specific proteins, including ARF6.

    Date Issued:
    2013-04-16
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Philip C. Trexler
    Patent Number:
    US 3059831 B2
    Description:

    This invention relates to improvements in connections between two sealed chambers, and methods of making the same, and more particularly to connections between an isolator for containing biological and other specimens within a controlled environment and a container therein and containing material to be introduced into the isolator or adapted to receive material to be discharged from an isolator.

    Date Issued:
    1962-10-23
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Edward A. Coomes, Fay E. Gifford
    Patent Number:
    US 2892740 B2
    Description:

    This invention relates to an improved thermionic emitter and to a method for making this emitter, and, more particularly, to filaments of refractory metal and a method for making these filaments.

    Date Issued:
    1959-06-30
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Gaetano Francis D'Alelio
    Patent Number:
    US 3639348 B2
    Description:

    The copolymers disclosed herein are of propargyl acrylate and methacrylate. Polymerization of propargyl acrylate and methacrylate in free radical systems generally results in crosslinked or gelled products since the free radicals will activate polymerization through the acetylenic as well as through the acrylic unsaturation. Therefore the copolymers are advantageously prepared byanionic polymerization. The comonomers are those which are copolymerizable with acrylates and methacrylates inanion…

    Date Issued:
    1972-02-01
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Robert M. Williams, James E. Bradner, Albert Bowers, Tenaya Newkirk, Olaf G. Wiest
    Patent Number:
    US 8513290 B2
    Description:

    Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.

    Date Issued:
    2013-08-20
    Record Visibility:
    Public
    Resource Type
    Patent