Search CurateND

Search criteria:

Department or Unit: Eck Institute for Global Health remove × Department or Unit: Integrated Imaging Facility remove ×
Clear all

List of files deposited in CurateND that match your search criteria

  • Author(s):
    Katheryn L. Smith, Micah J. Ferrell, Miguel A.. Morales, Brianna Norris-Mulins, Joseph S. Krivda
    Abstract:

    Leishmania parasites are responsible for important neglected diseases in humans and animals, ranging from self-healing cutaneous lesions to fatal visceral manifestations. During the infectious cycle, Leishmania differentiates from the extracellular flagellated promastigote to the intracellular pathogenic amastigote. Parasite differentiation is triggered by changes in environmental cues, mainly pH and temperature. In general, extracellular signals are translated into stage-specific gene expres…

    Date Published:
    2018-09
  • Author(s):
    Katheryn L. Smith, Micah J. Ferrell, Miguel A.. Morales
    Abstract:

    Leishmania parasites are responsible for important neglected diseases in humans and animals, ranging from self-healing cutaneous lesions to fatal visceral manifestations. During the infectious cycle, Leishmania differentiates from the extracellular flagellated promastigote to the intracellular pathogenic amastigote. Parasite differentiation is triggered by changes in environmental cues, mainly pH and temperature. In general, extracellular signals are translated into stage-specific gene expres…

    Date Published:
    2018-09
  • Author(s):
    Jeff Schorey, Yong Cheng
    Abstract:

    Extracellular vesicles (EVs) have been shown to carry microbial components and function in the host defense against infections. In this study, we demonstrate that Mycobacterium tuberculosis (M.tb) RNA is delivered into macrophage-derived EVs through an M.tb SecA2-dependent pathway, and that EVs released from M.tb-infected macrophages stimulate a host RIG-I/MAVS/TBK1/IRF3 RNA sensing pathway, leading to type I interferon production in recipient cells. These EVs also promote, in a RIG-I/MAVS-de…

    Date Published:
    2018-06