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  • Author(s):
    Hyein Do, Seung-Ryong Kwon, Seol Baek, Chinedu Madukoma, Marina Smiley, Lars Dietrich, Joshua Shrout, Paul Bohn
    Abstract:

    The opportunistic pathogen Pseudomonas aeruginosa (P. aeruginosa) produces several redox-Active phenazine metabolites, including pyocyanin (PYO) and phenazine-1-carboxamide (PCN), which are electron carrier molecules that also aid in virulence. In particular, PYO is an exclusive metabolite produced by P. aeruginosa, which acts as a virulence factor in hospital-Acquired infections and is therefore a good biomarker for identifying early stage colonization by this pathogen. Here, we describe the…

    Date Published:
    2021-01
    Record Visibility:
    Public
  • Author(s):
    Hyein Do, Seung-Ryong Kwon, Seol Baek, Chinedu S. Madukoma, Marina Smiley, Lars Dietrich, Joshua Shrout, Paul Bohn
    Abstract:

    The opportunistic pathogen Pseudomonas aeruginosa (P. aeruginosa) produces several redox-Active phenazine metabolites, including pyocyanin (PYO) and phenazine-1-carboxamide (PCN), which are electron carrier molecules that also aid in virulence. In particular, PYO is an exclusive metabolite produced by P. aeruginosa, which acts as a virulence factor in hospital-Acquired infections and is therefore a good biomarker for identifying early stage colonization by this pathogen. Here, we describe the…

    Date Published:
    2021-01
    Record Visibility:
    Public
  • Author(s):
    Paul Bohn
    Abstract:

    We present the results of acid-base experiments performed at the single ion (H+ or OH-) limit in ∼6 aL volume nanopores incorporating electrochemical zero-mode waveguides (E-ZMWs). At pH 3 each E-ZMW nanopore contains ca. 3600H+ ions, and application of a negative electrochemical potential to the gold working electrode/optical cladding layer reduces H+ to H2, thereby depleting H+ and increasing the local pH within the nanopore. The change in pH was quantified by tracking the intensity of fluo…

    Date Published:
    2020-09
    Record Visibility:
    Public
  • Author(s):
    Seol Baek, Seung-Ryong Kwon, Kaiyu Fu, Paul Bohn
    Abstract:

    NEA nanopores. Such selectively transported and confined ions are detected by using a 100 nm gap dual-ring nanoelectrode structure capable of enhancing current output by efficient redox cycling with an amplification factor >102. In addition, BCP@NEAs exhibit extraordinary pH-gated ion selectivity, resulting in a 3380-fold current difference between anion and cation probes at pH 3.0. This hierarchically organized BCP-gated NEA system can serve as a template for the development of other stim…

    Date Published:
    2020-11
    Record Visibility:
    Public
  • Author(s):
    Zhihong Pen, Trung T. Nguyen
    Abstract:

    Diabetic foot ulcers (DFUs) are a common complication of diabetes that are recalcitrant to healing due to persistent inflammation. The majority of DFUs have bacterial biofilms, with Staphylococcus epidermidis as a predominant bacterium, requiring infection control with antibiotics before treatment of the wound. Matrix metalloproteinases (MMPs) play roles in the pathology and repair of DFUs. However, defining the roles of the 24 human MMPs has been challenging due to the presence of three form…

    Date Published:
    2020-09
    Record Visibility:
    Public
  • Author(s):
    Gozde Basara, Mortaza Saeidi-Javash, Xiang Ren, Godhan Bahcecioglu, Brian C. Wyatt, Babak Anasori, Yanliang Zhang, Pinar Zorlutuna
    Abstract:

    Tissue engineered cardiac patches have great potential as a therapeutic treatment for myocardial infarction (MI). However, for successful integration with the native tissue and proper function of the cells comprising the patch, it is crucial for these patches to mimic the ordered structure of the native extracellular matrix and the electroconductivity of the human heart. In this study, a new composite construct that can provide both conductive and topographical cues for human induced pluripot…

    Date Published:
    2020-12
    Record Visibility:
    Public
  • Author(s):
    Allison Young, Carlysa Oyama, Alejandro ClaureDeLaZerda, Yueying Liu, Matthew J. Ravosa, Vijayalaxmi Gupta, Andrea Jewell, Dineo Khabele, M. Sharon Stack
    Abstract:

    The majority of women with recurrent ovarian cancer (OvCa) develop malignant ascites with volumes that can reach > 2 L. The resulting elevation in intraperitoneal pressure (IPP), from normal values of 5 mmHg to as high as 22 mmHg, causes striking changes in the loading environment in the peritoneal cavity. The effect of ascites-induced changes in IPP on OvCa progression is largely unknown. Herein we model the functional consequences of ascites-induced compression on ovarian tumor cells and…

    Date Published:
    2020-04
    Record Visibility:
    Public
  • Author(s):
    Courtney Hollar, Zhaoyang Lin, Madhusudan Kongara, Tony Varghese, Chinnathambi Karthik, Jess Schimpf, Josh Eixenberger, Paul Davis, Yaqio Wu, Xiangfeng Duan, Yanliang Zhang, David Estrada
    Abstract:

    Thermoelectric generators are an environmentally friendly and reliable solid-state energy conversion technology. Flexible and low-cost thermoelectric generators are especially suited to power flexible electronics and sensors using body heat or other ambient heat sources. Bismuth telluride (Bi2Te3) based thermoelectric materials exhibit their best performance near room temperature making them an ideal candidate to power wearable electronics and sensors using body heat. In this report, Bi2Te3 t…

    Date Published:
    2020-05
    Record Visibility:
    Public
  • Author(s):
    Ilia Pavlovetc, Michael Brennan, Seriu Draguta, Anthony Ruth, Taylor Moot, Jeffrey A. Christians, Kyle Aleshire, Steve Harvey, Stefano Toso, Sanjini Nanyakkara, Jonah Messinger, Joseph Luther, Marsaru Kuno
    Abstract:

    on migration represents an intrinsic instability of metal halide perovskite solar cells. Here we show that triple-cation FAxMAyCs1-x-yPbI3 [FA+ = (NH2)2CH+, MA+ = CH3NH3+] active layers with mixed orthorhombic, post-perovskite (δortho-CsPbI3), and cubic perovskite (α) phases (i.e., α/δ-phase FAxMAyCs1-x-yPbI3) exhibit improved cation stability against applied bias relative to pure α-phase perovskites (i.e., FA0.85Cs0.15PbI3 and FA0.76MA0.15Cs0.09PbI3). Infrared photothermal heterodyne imaging…

    Date Published:
    2020-08
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    Public
  • Author(s):
    Seung-Ryong Kwon, Seol Baek, Kaiyu Fu, Paul Bohn
    Abstract:

    Understanding water behavior in confined volumes is important in applications ranging from water purification to healthcare devices. Especially relevant are wetting and dewetting phenomena which can be switched by external stimuli, such as light and electric fields. Here, these behaviors are exploited for electrochemical processing by voltage-directed ion transport in nanochannels contained within nanopore arrays in which each nanopore presents three electrodes. The top and middle electrodes …

    Date Published:
    2020-04
    Record Visibility:
    Public
  • Author(s):
    Ramesh Shrestha, Yuxuan Luan, Xiao Luo, Summi Shi, Teng Zhang, Phil Smith, Wei Gong, Michael Bockstaller, Tenfei Luo, Renkun Chen, Kedar Hippalgaonkar, Shen Shen
    Abstract:

    Thermal rectification is an exotic thermal transport phenomenon which allows heat to transfer in one direction but block the other. We demonstrate an unusual dual-mode solid-state thermal rectification effect using a heterogeneous “irradiated-pristine” polyethylene nanofiber junction as a nanoscale thermal diode, in which heat flow can be rectified in both directions by changing the working temperature. For the nanofiber samples measured here, we observe a maximum thermal rectification factor…

    Date Published:
    2020-06
    Record Visibility:
    Public
  • Author(s):
    Chao Tang, Andriy Yaroshchuk, Merlin Bruening
    Abstract:

    Flow through negatively charged nanopores separates Li+and K+with selectivities of up to 70 and Li+passages from 20% to above 100%. Remarkably, both the Li+/K+selectivity and Li+passage initially increase with flow rate, breaking the permeability/selectivity trade-off. Modelling demonstrates that flow through the membranes creates electric fields that retard transport of cations. Selectivity increases with flow rate because the K+electromigration velocity exceeds its convective velocity, but …

    Date Published:
    2020-05
    Record Visibility:
    Public