Integrated Imaging Facility

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  • Author(s):
    Christopher D. Kagelman, Devon E. Mason, James H. Dawahare, Genevieve D. Vigil, Scott S. Howard, Teresita M. Bellido, Alexander G. Robling, Joel Boerckel
    Abstract:

    The functions of the transcriptional co-activators YAP and TAZ in bone are controversial. Each has been observed to either promote or inhibit osteogenesis in vitro, while their roles in bone development are unknown. Here we report that combinatorial YAP/TAZ deletion from skeletal cells in mice caused osteogenesis imperfecta with severity dependent on targeted cell lineage and allele dosage. Osteocyte-conditional deletion impaired bone accrual and matrix collagen, while allele dosage-dependent…

    Date Published:
    2017-05
    Record Visibility:
    Public
  • Author(s):
    Anna M. McDermott, Samuel Herberg, Devon E. Mason, Hope B. Pearson, James H. Dawahare, Joseph M. Collins, Rui Tang, Amit Patwa, Mark W. Grinstaff, Daniel J. Kelly, Eben Alsberg, Joel D. Boerckel
    Abstract:

    Natural fracture healing recapitulates bone development through endochondral ossification, resulting in clinical success rates of 90-95%. However, large bone defects of critical size cannot form a callus and exhibit high rates of complication and non-union even after intervention. Bone tissue engineering holds promise, but traditional approaches have focused on direct, intramembranous bone formation. We propose that mimicking the endochondral process that is naturally selected for bone develo…

    Date Published:
    2017
    Record Visibility:
    Public