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  Article

  RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix-detached cells
  

  Author(s):

  Cassandra L. Gorsuch, Patrick Fagan, Chan Lee, Sun Eun Kim, Jens C. Hamann, Joshua A. Mason, Kelsey J. Weigel, Matyas Abel Tsegaye, Luqun Shen, Sydney Shuff, Junjun Zuo, Stephan Hu, Lei jJiang, Sarah Chapman, W. Matthew Leevy, Ralph J. DeBerardinis, Michael Overholtzer, Zachary T. Schafer

  Abstract:

  For cancer cells to survive during extracellular matrix (ECM) detachment, they must inhibit anoikis and rectify metabolic deficiencies that cause non-apoptotic cell death. Previous studies in ECM-detached cells have linked non-apoptotic cell death to reactive oxygen species (ROS) generation, although the mechanistic underpinnings of this link remain poorly defined. Here, we uncover a role for receptor-interacting protein kinase 1 (RIPK1) in the modulation of ROS and cell viability during ECM …

  Date Published:

  2018-03

  Record Visibility:

  Public