Notre Dame Research

Search criteria:

List of files deposited in CurateND that match your search criteria

• 1

  Article

  Non-invasive in vivo fluorescence imaging of apoptotic retinal photoreceptors
  

  Author(s):

  Francesca Manzoni, Claudia Muller, Jonathan DeAssis, Deborah Lew, W. Matthew Leevy, Silvia Finnegan

  Abstract:

  Phosphatidylserine externalization is an early molecular signature for apoptosis. In many retinal degenerative diseases, photoreceptor neurons die by apoptosis. Here, we report utility of the phosphatidylserine-binding conjugate of Bis(zinc(II)-dipicolylamine (Zn-DPA) with Texas-red (PSVue-550) in transiently labeling apoptotic photoreceptors in living pigmented or albino rats and mice with retinal degeneration. Applying PSVue-550 as eyedrop is non-toxic and eliminates need for intraocular in…

  Date Published:

  2019-02

  Record Visibility:

  Public