Notre Dame Research

Search CurateND

Search criteria:

Department or Unit: Notre Dame Research remove × Type of Work: Dataset OR Article remove ×
Clear all

List of files deposited in CurateND that match your search criteria

  • Author(s):
    Ricardo Romer-Moreno, Kimberly Curtis, Thomas Couglin, Maria Mieranda-Vergara, Shourik Dutta, Aishwarya Natarajan, Beth Facchine, Kristen Jackson, Lukas Nystrom, Jun Li, William Kaliney, Glen Niebur, Laurie Littlepage
    Abstract:

    Bone is one of the most common sites for metastasis across cancers. Cancer cells that travel through the vasculature and invade new tissues can remain in a non-proliferative dormant state for years before colonizing the metastatic site. Switching from dormancy to colonization is the rate-limiting step of bone metastasis. Here we develop an ex vivo co-culture method to grow cancer cells in mouse bones to assess cancer cell proliferation using healthy or cancer-primed bones. Profiling soluble f…

    Date Published:
    2019-07
    Record Visibility:
    Public
  • Author(s):
    Ricardo Romer-Moreno, Kimberly Curtis, Thomas Couglin, Maria Mieranda-Vergara, Shourik Dutta, Aishwarya Natarajan, Beth Facchine, Kristen Jackson, Lukas Nystrom, Jun Li, William Kaliney, Glen Niebur, Laurie Littlepage
    Abstract:

    Bone is one of the most common sites for metastasis across cancers. Cancer cells that travel through the vasculature and invade new tissues can remain in a non-proliferative dormant state for years before colonizing the metastatic site. Switching from dormancy to colonization is the rate-limiting step of bone metastasis. Here we develop an ex vivo co-culture method to grow cancer cells in mouse bones to assess cancer cell proliferation using healthy or cancer-primed bones. Profiling soluble f…

    Date Published:
    2019-07
    Record Visibility:
    Public
  • Author(s):
    Keon R. Schmidt, Barnes Werner, Jenna Koenig, Ian Guldner, Patricia Schnepp, Xuejuan Tan, Lan Jiang, Misha Host, Longhua Sun, Erin Howe, Junmin Wu, Laurie Littlepage, Harikrishna Nakshtri, Siyua Zhang
    Abstract:

    Lacking targetable molecular drivers, triple-negative breast cancer (TNBC) is the most clinically challenging subtype of breast cancer. In this study, we reveal that Death Effector Domain-containing DNA-binding protein (DEDD), which is overexpressed in > 60% of TNBCs, drives a mitogen-independent G1/S cell cycle transition through cytoplasm localization. The gain of cytosolic DEDD enhances cyclin D1 expression by interacting with heat shock 71 kDa protein 8 (HSC70). Concurrently, DEDD inte…

    Date Published:
    2019-07
    Record Visibility:
    Public
  • Author(s):
    Maria Cristina Miranda-Vergara, Shourik Dutta, Aishwarya Natarajan, Beth Facchine, Kristen Jackson, Lukas Nystrom, Jun Li, William Kaliney, Glen Niebur, Laurie Littlepage
    Abstract:

    Bone is one of the most common sites for metastasis across cancers. Cancer cells that travel through the vasculature and invade new tissues can remain in a non-proliferative dormant state for years before colonizing the metastatic site. Switching from dormancy to colonization is the rate-limiting step of bone metastasis. Here we develop an ex vivo co-culture method to grow cancer cells in mouse bones to assess cancer cell proliferation using healthy or cancer-primed bones. Profiling soluble f…

    Record Visibility:
    Public