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  • Author(s):
    Annemarie K. Leonard, Elizabeth A. Loughran, Yuliya Klymenko, Yueying Liu, Oleg Kim, Marwa Asem, Kevin McAbee, Matthew J. Ravosa, M. Sharon Stack
    Abstract:

    This chapter highlights methods for visualization and analysis of extracellular matrix (ECM) proteins, with particular emphasis on collagen type I, the most abundant protein in mammals. Protocols described range from advanced imaging of complex in vivo matrices to simple biochemical analysis of individual ECM proteins. The first section of this chapter describes common methods to image ECM components and includes protocols for second harmonic generation, scanning electron microscopy, and seve…

    Date Published:
    2018
    Record Visibility:
    Public
  • Author(s):
    Peter Höök, Teresa Brito-Robinson, Oleg Kim, Cody Narciso, Holly V. Goodson, John W. Weisel, Mark S. Alber, Jeremiah J. Zartman
    Abstract:

    A technological revolution in both light and electron microscopy imaging now allows unprecedented views of clotting, especially in animal models of hemostasis and thrombosis. However, our understanding of three-dimensional high-resolution clot structure remains incomplete since most of our recent knowledge has come from studies of relatively small clots or thrombi, due to the optical impenetrability of clots beyond a few cell layers in depth. Here, we developed an optimized optical clearing m…

    Date Published:
    2017
    Record Visibility:
    Public