Notre Dame Research

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  • Author(s):
    Ryan Roeder, Tyler Curtis
    Abstract:

    Quantitative material decomposition of multiple mixed, or spatially coincident, contrast agent (gadolinium and iodine) and tissue (calcium and water) compositions is demonstrated using photon-counting spectral computed tomography (CT). Material decomposition is performed using constrained maximum like- lihood estimation (MLE) in the image domain. MLE is calibrated by multiple linear regression of all pure material compositions, which exhibits a strong correlation (R2 > 0.91) between the me…

    Date Published:
    2019-01
  • Author(s):
    Lisa Irimata, Tracy Vargo-Gogola, Ryan Roeder
    Abstract:

    A preclinical murine model of hydroxyapatite (HA) breast microcalcifications (µcals), which are an important clinical biomarker for breast cancer detection, was used to investigate the independent effects of high affinity bisphosphonate (BP) ligands and a polyethylene glycol (PEG) spacer on targeted delivery of gold nanoparticles (Au NPs) for contrast-enhanced radiographic detection. The addition of BP ligands to PEGylated Au NPs (BP-PEG-Au NPs) resulted in five-fold greater binding affinity …

    Date Published:
    2018
  • Author(s):
    Ryan Roeder
    Abstract:

    All living tissues and cells on Earth are subject to gravitational acceleration, but no reports have verified whether acceleration mode influences bone formation and healing. Therefore, this study was to compare the effects of two acceleration modes, vibration and constant (centrifugal) accelerations, on bone formation and healing in the trunk using BMP 2-induced ectopic bone formation (EBF) mouse model and a rib fracture healing (RFH) rat model. Additionally, we tried to verify the differenc…

    Date Published:
    2017-03
  • Author(s):
    Ryan Roeder
    Abstract:

    All living tissues and cells on Earth are subject to gravitational acceleration, but no reports have verified whether acceleration mode influences bone formation and healing. Therefore, this study was to compare the effects of two acceleration modes, vibration and constant (centrifugal) accelerations, on bone formation and healing in the trunk using BMP 2-induced ectopic bone formation (EBF) mouse model and a rib fracture healing (RFH) rat model. Additionally, we tried to verify the differenc…

    Date Published:
    2017-03