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  • Author(s):
    Keon R. Schmidt, Barnes Werner, Jenna Koenig, Ian Guldner, Patricia Schnepp, Xuejuan Tan, Lan Jiang, Misha Host, Longhua Sun, Erin Howe, Junmin Wu, Laurie Littlepage, Harikrishna Nakshtri, Siyua Zhang
    Abstract:

    Lacking targetable molecular drivers, triple-negative breast cancer (TNBC) is the most clinically challenging subtype of breast cancer. In this study, we reveal that Death Effector Domain-containing DNA-binding protein (DEDD), which is overexpressed in > 60% of TNBCs, drives a mitogen-independent G1/S cell cycle transition through cytoplasm localization. The gain of cytosolic DEDD enhances cyclin D1 expression by interacting with heat shock 71 kDa protein 8 (HSC70). Concurrently, DEDD inte…

    Date Published:
    2019-07
    Record Visibility:
    Public
  • Author(s):
    Rachel Bonek, Gregory Snider, Alexei Orlov
    Abstract:

    In this paper, we present results demonstrating the effect of temperature on singular- ity matching (SM) tunneling down to 300 mK in superconducting single-electron transistors (SSETs). The studied SSETs have charging energies significantly larger than the Josephson energy, which makes it possible to study the SM condition with- out other sub-superconducting gap conduction mechanisms obscuring the SM signa- tures at low biases. The presence of parity in one such device has also allowed us to …

    Date Published:
    2019-03
    Record Visibility:
    Public
  • Author(s):
    Kimberly Curtis, Thomas Coughlin, Mary Varsanik, Glen Niebur
    Abstract:

    Introduction: Mechanical stimulation of bone is necessary to maintain its mass and architecture. Osteocytes within the mineralized matrix are sensors of mechanical deformation of the hard tissue, and communicate with cells in the marrow to regulate bone remodeling. However, marrow cells are also subjected to mechanical stress during whole bone loading, and may contribute to mechanically regulated bone physiology. Previous results from our laboratory suggest that mechanotransduction in marrow …

    Date Published:
    2019-08
    Record Visibility:
    Public
  • Author(s):
    Patrick Barboun, Prateek Mehta, Francisco Herrera, David Go, William Schneider, Jason Hicks
    Abstract:

    Plasma-assisted catalysis is the process of electrically activating gases in the plasma-phase at low temperatures and ambient pressure to drive reactions on catalyst surfaces. Plasma-assisted catalytic processes combine conventional heterogeneous surface reactions, homogeneous plasma phase reactions, and coupling between plasma-generated species and the catalyst surface. Herein, we perform kinetically controlled ammonia synthesis measurements in a dielectric barrier discharge (DBD) plasma-ass…

    Date Published:
    2019-07
    Record Visibility:
    Public
  • Author(s):
    Kazuki Nomoto, Aditya Sundar, Kevin Lee, Mingda Zhu, Zongyang Hu, Edward Beam, Jinqiao Xie, Manyam Pilla, Xiang Gao, Sergei Rouvimiov, Debdeep Jena, Hulli Grace Xing
    Abstract:

    GaN PolarMOS is a vertical power transistor incorporating the unique polarization-induced bulk doping scheme in III-nitrides for the body p-n junction. We report the realization of this device, wherein the vertical channel, source contact, and body contact regions are successfully formed using three steps of selective-area epitaxial regrowth, all by molecular beam epitaxy (MBE). The fabricated PolarMOS has an excellent on-current of >500 mA mm−1 and a specific on-resistance of 0.66 mΩ · cm…

    Date Published:
    2019-06
    Record Visibility:
    Public
  • Author(s):
    Luke Sadergaski, Meena Said, Amy Hixon
    Abstract:

    The unique and diverse features of uranyl peroxide nanoclusters may contribute to the enhanced mobility of uranium in the environment. This study examines the sorption of the uranyl peroxide nanocluster [UO2(O2)(OH)]6060‑ (U60) to Na-montmorillonite (SWy-2), plagioclase (anorthite), and quartz (SiO2) as a function of time, U60 concentration, and mineral concentration. SWy-2 was studied in both its untreated form as well as after two different pretreatments, denoted as partially treated SWy-2 a…

    Date Published:
    2019-09
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    Public
  • Author(s):
    James Zokoe, Changsheng Su, Paul J. McGinn
    Abstract:

    Potassium volatility and activity in a novel K-Ca-Si-O glass catalyst was investigated over extended periods of soot oxidation. Soot was continuously deposited and oxidized by maintaining a glass catalyst-coated filter at temperatures above the oxidation balance point to provide a soot mass equivalent to 100 000 miles of engine operation. Testing revealed the 52-SiO2, 35-K2O, and 13-CaO wt % glass catalysts show a significant improvement in soot oxidation performance over a Pt catalyst. The g…

    Date Published:
    2019-07
    Record Visibility:
    Public
  • Author(s):
    Yide Zhang, Takashi Hato, Pierre Dagher, Evan Nichols, Cody Smith, Kenneth Dunn, Scott Howard
    Abstract:

    Fluorescence lifetime imaging microscopy (FLIM) provides additional contrast for fluorophores with overlapping emission spectra. The phasor approach to FLIM greatly reduces the complexity of FLIM analysis and enables a useful image segmentation technique by selecting adjacent phasor points and labeling their corresponding pixels with different colors. This phasor labeling process, however, is empirical and could lead to biased results. In this Letter, we present a novel and unbiased approach …

    Date Published:
    2019-08
    Record Visibility:
    Public
  • Author(s):
    Kimberly Curtis, Alyssa Oberman, Glen Niebur
    Abstract:

    Bone marrow is a cellular tissue that forms within the pore space and hollow diaphysis of bones. As a tissue, its primary function is to support the hematopoietic progenitor cells that maintain the populations of both erythroid and myeloid lineage cells in the bone marrow, making it an essential element of normal mammalian physiology. However, bone’s primary function is load bearing, and deformations induced by external forces are transmitted to the encapsulatedmarrow.Understanding the effect…

    Date Published:
    2019-08
    Record Visibility:
    Public
  • Author(s):
    V. S. Buinevich, A. A. Nepapushev, G. V. Trusov, D. O. Moskovskikh, A. S. Rogachev, A. S. Mukasyan
    Abstract:

    The future of the aerospace industry is directly related to the development and modernization of the heat-loaded components of hypersonic aircraft: jet engines, nose tips and sharp leading edges of the wings, which are required to withstand ultrahigh temperatures (above 2000°C) caused by aerodynamic heating. The greatest practical interest for the aerospace industry is centered around ultra-high temperature ceramics based on borides, nitrides, carbides, carbonitrides and double transition met…

    Date Published:
    2019-01
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    Public
  • Author(s):
    Chaochao Dun, Nicholas Kempf, Mortaza Saeidi-Javash, Chinathambi Karthik, Joseph Richardson, Courtney Hollar, David Estrada, Yanliang Zhang
    Abstract:

    Printing is a versatile method to transform semiconducting nanoparticle inks into functional and flexible devices. In particular, thermoelectric nanoparticles are attractive building blocks to fabricate flexible devices for energy harvesting and cooling applications. However, the performance of printed devices are plagued by poor interfacial connections between nanoparticles and resulting low carrier mobility. While many rigid bulk materials have shown a thermoelectric figure of merit ZT grea…

    Date Published:
    2019-07
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    Public
  • Author(s):
    Jiayu Liu, Ibrahem Jasim, Muhammad Roman, Yuyao Yang, Chuang Qu, Jie Huang, Edward Kinzel, Mahmoud Almasri
    Abstract:

    This paper presents a technique for the low-cost fabrication of plasmonic fiber-optic based refractive-index sensors. The Microsphere Photolithography (MPL) technique was used to pattern nanoholes in a thin aluminum film to create Extraordinary Optical Transmission (EOT) based sensors on the cleaved tip of SMF-28 optical fibers. This technique uses self-assembled microspheres as an optical element and facilitates very low-cost patterning of the plasmonic probes. As the refractive index of the…

    Date Published:
    2019-06
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    Public