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  • Author(s):
    Keon R. Schmidt, Barnes Werner, Jenna Koenig, Ian Guldner, Patricia Schnepp, Xuejuan Tan, Lan Jiang, Misha Host, Longhua Sun, Erin Howe, Junmin Wu, Laurie Littlepage, Harikrishna Nakshtri, Siyua Zhang
    Abstract:

    Lacking targetable molecular drivers, triple-negative breast cancer (TNBC) is the most clinically challenging subtype of breast cancer. In this study, we reveal that Death Effector Domain-containing DNA-binding protein (DEDD), which is overexpressed in > 60% of TNBCs, drives a mitogen-independent G1/S cell cycle transition through cytoplasm localization. The gain of cytosolic DEDD enhances cyclin D1 expression by interacting with heat shock 71 kDa protein 8 (HSC70). Concurrently, DEDD inte…

    Date Published:
    2019-07
    Record Visibility:
    Public