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  • Author(s):
    Paul J. McGinn
    Abstract:

    High-throughput combinatorial investigations are transforming materials discovery, phase diagram development, and processing optimization. Thin-film deposition techniques are frequently used to fabricate sample libraries employed in these studies. Various adaptations of well-known thin-film chemical vapor deposition (CVD) and physical vapor deposition (PVD) techniques utilized for the synthesis of inorganic combinatorial thin-film materials libraries are reviewed, with novel processing approa…

    Date Published:
    2019-08
    Record Visibility:
    Public
  • Author(s):
    N Kryzhanovskaya, E. Moiseev, F. I. Zubov, A. M. Mozharov, M. V. Maximov, N. A. Kalyuzhnyy, S. A. Mintariov, Yu Bernikov, S. Rouvimov, A. E. Zhukov
    Abstract:

    GaAs-based microdisk lasers with an active region representing a dense array of indium-rich islands (InGaAs quantum well-dots) were studied using direct small-signal modulation. We demonstrate that using dense arrays of InGaAs quantum well-dots enables uncooled high-frequency applications with a GHz-range bandwidth for microdisk lasers. A maximum 3 dB modulation frequency of 5.9 GHz was found in the microdisk with a radius of 13.5 μm operating without a heatsink for cooling. A modulation curr…

    Date Published:
    2019-05
    Record Visibility:
    Public
  • Author(s):
    Ricardo Romer-Moreno, Kimberly Curtis, Thomas Couglin, Maria Mieranda-Vergara, Shourik Dutta, Aishwarya Natarajan, Beth Facchine, Kristen Jackson, Lukas Nystrom, Jun Li, William Kaliney, Glen Niebur, Laurie Littlepage
    Abstract:

    Bone is one of the most common sites for metastasis across cancers. Cancer cells that travel through the vasculature and invade new tissues can remain in a non-proliferative dormant state for years before colonizing the metastatic site. Switching from dormancy to colonization is the rate-limiting step of bone metastasis. Here we develop an ex vivo co-culture method to grow cancer cells in mouse bones to assess cancer cell proliferation using healthy or cancer-primed bones. Profiling soluble f…

    Date Published:
    2019-07
    Record Visibility:
    Public
  • Author(s):
    Ricardo Romer-Moreno, Kimberly Curtis, Thomas Couglin, Maria Mieranda-Vergara, Shourik Dutta, Aishwarya Natarajan, Beth Facchine, Kristen Jackson, Lukas Nystrom, Jun Li, William Kaliney, Glen Niebur, Laurie Littlepage
    Abstract:

    Bone is one of the most common sites for metastasis across cancers. Cancer cells that travel through the vasculature and invade new tissues can remain in a non-proliferative dormant state for years before colonizing the metastatic site. Switching from dormancy to colonization is the rate-limiting step of bone metastasis. Here we develop an ex vivo co-culture method to grow cancer cells in mouse bones to assess cancer cell proliferation using healthy or cancer-primed bones. Profiling soluble f…

    Date Published:
    2019-07
    Record Visibility:
    Public
  • Author(s):
    Keon R. Schmidt, Barnes Werner, Jenna Koenig, Ian Guldner, Patricia Schnepp, Xuejuan Tan, Lan Jiang, Misha Host, Longhua Sun, Erin Howe, Junmin Wu, Laurie Littlepage, Harikrishna Nakshtri, Siyua Zhang
    Abstract:

    Lacking targetable molecular drivers, triple-negative breast cancer (TNBC) is the most clinically challenging subtype of breast cancer. In this study, we reveal that Death Effector Domain-containing DNA-binding protein (DEDD), which is overexpressed in > 60% of TNBCs, drives a mitogen-independent G1/S cell cycle transition through cytoplasm localization. The gain of cytosolic DEDD enhances cyclin D1 expression by interacting with heat shock 71 kDa protein 8 (HSC70). Concurrently, DEDD inte…

    Date Published:
    2019-07
    Record Visibility:
    Public
  • Author(s):
    Rachel Bonek, Gregory Snider, Alexei Orlov
    Abstract:

    In this paper, we present results demonstrating the effect of temperature on singular- ity matching (SM) tunneling down to 300 mK in superconducting single-electron transistors (SSETs). The studied SSETs have charging energies significantly larger than the Josephson energy, which makes it possible to study the SM condition with- out other sub-superconducting gap conduction mechanisms obscuring the SM signa- tures at low biases. The presence of parity in one such device has also allowed us to …

    Date Published:
    2019-03
    Record Visibility:
    Public
  • Author(s):
    Kimberly Curtis, Thomas Coughlin, Mary Varsanik, Glen Niebur
    Abstract:

    Introduction: Mechanical stimulation of bone is necessary to maintain its mass and architecture. Osteocytes within the mineralized matrix are sensors of mechanical deformation of the hard tissue, and communicate with cells in the marrow to regulate bone remodeling. However, marrow cells are also subjected to mechanical stress during whole bone loading, and may contribute to mechanically regulated bone physiology. Previous results from our laboratory suggest that mechanotransduction in marrow …

    Date Published:
    2019-08
    Record Visibility:
    Public
  • Author(s):
    Patrick Barboun, Prateek Mehta, Francisco Herrera, David Go, William Schneider, Jason Hicks
    Abstract:

    Plasma-assisted catalysis is the process of electrically activating gases in the plasma-phase at low temperatures and ambient pressure to drive reactions on catalyst surfaces. Plasma-assisted catalytic processes combine conventional heterogeneous surface reactions, homogeneous plasma phase reactions, and coupling between plasma-generated species and the catalyst surface. Herein, we perform kinetically controlled ammonia synthesis measurements in a dielectric barrier discharge (DBD) plasma-ass…

    Date Published:
    2019-07
    Record Visibility:
    Public
  • Author(s):
    Kazuki Nomoto, Aditya Sundar, Kevin Lee, Mingda Zhu, Zongyang Hu, Edward Beam, Jinqiao Xie, Manyam Pilla, Xiang Gao, Sergei Rouvimiov, Debdeep Jena, Hulli Grace Xing
    Abstract:

    GaN PolarMOS is a vertical power transistor incorporating the unique polarization-induced bulk doping scheme in III-nitrides for the body p-n junction. We report the realization of this device, wherein the vertical channel, source contact, and body contact regions are successfully formed using three steps of selective-area epitaxial regrowth, all by molecular beam epitaxy (MBE). The fabricated PolarMOS has an excellent on-current of >500 mA mm−1 and a specific on-resistance of 0.66 mΩ · cm…

    Date Published:
    2019-06
    Record Visibility:
    Public
  • Author(s):
    Luke Sadergaski, Meena Said, Amy Hixon
    Abstract:

    The unique and diverse features of uranyl peroxide nanoclusters may contribute to the enhanced mobility of uranium in the environment. This study examines the sorption of the uranyl peroxide nanocluster [UO2(O2)(OH)]6060‑ (U60) to Na-montmorillonite (SWy-2), plagioclase (anorthite), and quartz (SiO2) as a function of time, U60 concentration, and mineral concentration. SWy-2 was studied in both its untreated form as well as after two different pretreatments, denoted as partially treated SWy-2 a…

    Date Published:
    2019-09
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    Public
  • Author(s):
    James Zokoe, Changsheng Su, Paul J. McGinn
    Abstract:

    Potassium volatility and activity in a novel K-Ca-Si-O glass catalyst was investigated over extended periods of soot oxidation. Soot was continuously deposited and oxidized by maintaining a glass catalyst-coated filter at temperatures above the oxidation balance point to provide a soot mass equivalent to 100 000 miles of engine operation. Testing revealed the 52-SiO2, 35-K2O, and 13-CaO wt % glass catalysts show a significant improvement in soot oxidation performance over a Pt catalyst. The g…

    Date Published:
    2019-07
    Record Visibility:
    Public
  • Author(s):
    Yide Zhang, Takashi Hato, Pierre Dagher, Evan Nichols, Cody Smith, Kenneth Dunn, Scott Howard
    Abstract:

    Fluorescence lifetime imaging microscopy (FLIM) provides additional contrast for fluorophores with overlapping emission spectra. The phasor approach to FLIM greatly reduces the complexity of FLIM analysis and enables a useful image segmentation technique by selecting adjacent phasor points and labeling their corresponding pixels with different colors. This phasor labeling process, however, is empirical and could lead to biased results. In this Letter, we present a novel and unbiased approach …

    Date Published:
    2019-08
    Record Visibility:
    Public