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  • Author(s):
    J. Schiltz, Andrew Rosenberger, Todd Render, Bernice Aboud Gatrell, Haibo Qu, Colton Steiner, Paul McGinn, Steve Schmid
    Abstract:

    Ceramics have exceptional tribological performance in high wear applications, but susceptibility to brittle fracture requires expensive postprocessing, including hot isostatic pressing and polishing. Consequently, additive manufacturing (AM) represents a collection of potentially costsaving approaches for ceramic production. AM technologies have been demonstrated for oxide ceramics, but the performance of self-mated AM materials remains unknown and underscores a critical knowledge gap. Alumin…

    Date Published:
    2019-06
  • Author(s):
    A. Vania Apkarian, Kasturi Halder, Suhail Alam, Maria Virginia Centeno
    Abstract:

    The disclosure relates to use of a triple formulation comprising a histone deacytlase, a cyclodextrin and polyethylene glycol or propylene glycol, and in the treatment and management of chronic pain.

    Date Created:
    2019-10-15
    Resource Type
    Document
  • Author(s):
    Pierre C. Dagher, Evan L. Nichols, Cody J. Smith, Kenneth W. Dunn, Scott S. Howard
    Abstract:

    Fluorescence lifetime imaging microscopy (FLIM) provides additional contrast for fluorophores with overlapping emission spectra. The phasor approach to FLIM greatly reduces the complexity of FLIM analysis and enables a useful image segmentation technique by selecting adjacent phasor points and labeling their corresponding pixels with different colors. This phasor labeling process, however, is empirical and could lead to biased results. In this Letter, we present a novel and unbiased approach …

    Date Published:
    2019-08
  • Author(s):
    Yide Zhang, Yinhao Zhu, Evan Nichols, Qingfei Wang, Siyuang Zhang, Cody Smith, Scott Howard
    Abstract:

    Fluorescence microscopy has enabled a dramatic development in modern biology. Due to its inherently weak signal, fluorescence microscopy is not only much noisier than photography, but also presented with Poisson-Gaussian noise where Poisson noise, or shot noise, is the dominating noise source. To get clean fluorescence microscopy images, it is highly desirable to have effective denoising algorithms and datasets that are specifically designed to denoise fluorescence microscopy images. While su…

    Date Created:
    2019-10-15
    Resource Type
    Presentation
  • Author(s):
    S. Herberg, A. M. McDermott, P. N. Dang, D. S. Alt, R. Tang, J. H. Dawahare, D. Varghai, J-Y. Shin, A. McMillan, A. D. Dikina, F. He, Y. Lee, Y. Cheng, K. Umemori, P. C. Wong, H. Park, J. D. Boerckel, E. Alsberg
    Abstract:

    Endochondral ossification during long bone development and natural fracture healing initiates by mesenchymal cell condensation, directed by local morphogen signals and mechanical cues. Here, we aimed to mimic development for regeneration of large bone defects. We hypothesized that engineered human mesenchymal condensations presenting transforming growth factor–β1 (TGF-β1) and/or bone morphogenetic protein-2 (BMP-2) from encapsulated microparticles promotes endochondral defect regeneration con…

  • Author(s):
    Christopher Smyth, Lee Walsh, Pavel Bolshakov, Massimo Catalano, Michael Schmidt, Brendan Sheehan, Rafik Addou, Luhua Wang, Jiyoung Kim, Moon Kim, Christopher Hinkle, Robert Wallace
    Abstract:

    Sc has been employed as an electron contact to a number of two-dimensional (2D) materials (e.g. MoS2, black phosphorous) and has enabled, at times, the lowest electron contact resistance. However, the extremely reactive nature of Sc leads to stringent processing requirements and metastable device performance with no true understanding of how to achieve consistent, high-performance Sc contacts. In this work, WSe2 transistors with impressive subthreshold slope (109 mV dec−1) and I ON/I OFF (106…

    Date Published:
    2019-07
  • Author(s):
    Christopher Smyth, Lee Walsh, Pavel Bolshakov, Massimo Catalano, Michael Schmidt, Brendan Sheehan, Rafik Addou, Luhua Wang, Jiyoung Kim, Moon Kim, Christopher Hinkle, Robert Wallace
    Abstract:

    Sc has been employed as an electron contact to a number of two-dimensional (2D) materials (e.g. MoS2, black phosphorous) and has enabled, at times, the lowest electron contact resistance. However, the extremely reactive nature of Sc leads to stringent processing requirements and metastable device performance with no true understanding of how to achieve consistent, high-performance Sc contacts. In this work, WSe2 transistors with impressive subthreshold slope (109 mV dec−1) and I ON/I OFF (106…

    Date Published:
    2019-07
  • Author(s):
    Sarah Peterson, Kyle Bibby
    Abstract:

    Fecal indicator bacteria currently employed for microbial water quality management are poor representatives of viruses. Viral water quality indicators have recently been proposed based on the human gut bacteriophage crAssphage and the food virus pepper mild mottle virus (PMMoV) due to their high abundance in sewage and association to human waste. Here, we develop a model relating crAssphage and PMMoV abundance to risk of swimmer illness in a recreational water contaminated with fresh, untreat…

    Date Published:
    2019-08
  • Author(s):
    Melissa Grupen-Shemansky, Paul Bohn
    Abstract:

    This report was developed under a DARPA contract for topic Atoms to products. Two primary goals were addressed in this project. In Focus Area 1 (Assembly Development) the goal was to assemble a 10 μm microelement consisting of an anisotropic lattice of ~5000 (~100 nm) dielectric nanoparticles (NPs) embedded in a polymer electrolyte. Successful completion of the objectives of this goal required that NPs be spatially located with nm-scale precision in a polymer matrix at scales up to ~10 μm (to…

    Date Published:
    2019-07
  • Author(s):
    Jin Qin, Edward Kinzel, Liang Wang
    Abstract:

    In this article, we demonstrate a specially designed resonant metamaterial with epsilon-near-zero (ENZ) and nanoantenna to enhance the exposure depth in plasmonic direct writing lithography more than 10 times. The ENZ metamaterial composed of a Ag/Si3N4 multilayer thin film, converts the evanescent field generated by the bowtie aperture nanoantenna to propagating waves with low divergence and high collimation. Deep sub-diffraction limited resolution of less than 65 nm (λ/7) with exposure dept…

    Date Published:
    2019-08
  • Author(s):
    Robert Hughes, Sergei Rouvimov, Robert Neal, Trevor B. Demille, Svetlana Neretina
    Abstract:

    The seed-mediated growth of noble metal nanostructures with planar geometries requires the use of seeds lined with parallel stacking faults so as to provide a break in symmetry in an otherwise isotropic metal. Although such seeds are now routinely synthesized using colloidal pathways, equivalent pathways have not yet been reported for the fabrication of substrate-based seeds with the same internal defect structures. The challenge is not merely to form seeds with planar defects but to do so in…

    Date Published:
    2019-07
  • Author(s):
    Shanmugam Panneer Selvam, Ryan De Palma, Kristen Johnson, Rasesh Parikh, Vamsi Gangaraju, Yuri Peterson, Mohammed Dany, Robert V. Stahelin, Christina Voelkel-Johnson, Zdzislaw Szuic, Erhard Bieberich, Besi Ogetmen
    Abstract:

    Formation of membrane pores/channels regulates various cellular processes, such as necroptosis or stem cell niche signaling. However, the roles of membrane lipids in the formation of pores and their biological functions are largely unknown. Here, using the cellular stress model evoked by the sphingolipid analog drug FTY720, we show that formation of ceramide-enriched membrane pores, referred to here as ceramidosomes, is initiated by a receptor-interacting Ser/Thr kinase 1 (RIPK1)-ceramide com…

    Date Published:
    2019-01