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  • Author(s):
    Matthew Sisk
    Abstract:

    Lead exposure is a major health hazard affecting children and their growth and is a concern in many urban areas around the world. One such city in the United States (US), South Bend Indiana, gained attention for its high levels of lead in blood and relatively low testing rates for children. We assessed current lead screening practices in South Bend and the surrounding St. Joseph County (SJC). The 2005–2015 lead screening data included 18,526 unique children. Lead screening rates ranged from 4…

  • Author(s):
    Yide Zhang, Scott S. Howard, Cody J. Smith
    Abstract:

    Super-resolution microscopy is broadening our in-depth understanding of cellular structure. However, super-resolution approaches are limited, for numerous reasons, from utilization in longer-term intravital imaging. We devised a combinatorial imaging technique that combines deconvolution with stepwise optical saturation microscopy (DeSOS) to circumvent this issue and image cells in their native physiological environment. Other than a traditional confocal or two-photon microscope, this approac…

    Date Created:
    2019-01-09
    Resource Type
    Software
  • Author(s):
    Md Suhail Alam, Bruce Cooper, Kasturi Halder
    Abstract:

    Histone deacetylase (HDAC) inhibitors are of significant interest as drugs. However, their use in neurological disorders has raised concern because HDACs are required for brain function. We have previously shown that a triple combination formulation (TCF) of the pan HDACi vorinostat (Vo) improves pharmacokinetic exposure and entry of Vo into the brain. TCF treatment significantly delayed both neurodegeneration and death in the Npc1nmf164 murine model of Niemann Pick Type C (NPC) disease. The …

    Date Published:
    2017-09
  • Author(s):
    Manuela Lahne, Clare E. Yarka, Michael E. Petravick, Jingling Li, David R. Hyde
    Abstract:

    Sox2 is a well-established neuronal stem cell-associated transcription factor that regulates neural development and adult neurogenesis in vertebrates, and is one of the critical genes used to reprogram differentiated cells into induced pluripotent stem cells. We examined if Sox2 was involved in the early reprogramming-like events that Müller glia undergo as they upregulate many pluripotency- and neural stem cell-associated genes required for proliferation in light-damaged adult zebrafish reti…

    Date Published:
    2017-08
  • Author(s):
    Jeff Schorey, Yong Cheng
    Abstract:

    Extracellular vesicles (EVs) have been shown to carry microbial components and function in the host defense against infections. In this study, we demonstrate that Mycobacterium tuberculosis (M.tb) RNA is delivered into macrophage-derived EVs through an M.tb SecA2-dependent pathway, and that EVs released from M.tb-infected macrophages stimulate a host RIG-I/MAVS/TBK1/IRF3 RNA sensing pathway, leading to type I interferon production in recipient cells. These EVs also promote, in a RIG-I/MAVS-de…

    Date Published:
    2018-06
  • Author(s):
    Paul T. Kroeger, Bridgette E. Drumond, Rachel Miceli, Michael McKernan, Gary F. Gerlach, Amanda N. Marra, Annemarie Fox, Kristen K. McCampbell, Ignaty Leshchiner, Adriana Rodriguez-Mari, Ruth Bremiller, Ryan Thummel, Alan J. Davidson, John Postlethwait, Wolfram Goessling, Rebecca Wingert
    Abstract:

    The zebrafish kidney is conserved with other vertebrates, making it an excellent genetic model to study renal development. The kidney collects metabolic waste using a blood filter with specialized epithelial cells known as podocytes. Podocyte formation is poorly understood but relevant to many kidney diseases, as podocyte injury leads to progressive scarring and organ failure. zeppelin (zep) was isolated in a forward screen for kidney mutants and identified as a homozygous recessive lethal al…

    Date Published:
    2017
  • Author(s):
    Matthew Sisk, Lacey Ahern, Heidi Beidinger, Danielle LaFleur, Michelle Ngai
    Abstract:

    Lead exposure in SJC continues to be a persistent, complex public health issue. Data released in December 2016 showed that census tract 6 in South Bend had the highest rates of EBLL in the state of Indiana. Because lead exposure can produce significant cognitive and physiological damage even at very low levels of exposure, immediate action was required. Understanding what the epidemiologic profile of lead in SJC was among the first steps taken to address this issue. The St. Joseph Coun…

    Date Published:
    2017-07
  • Author(s):
    Julie Braungart-Rieker, Elizabeth Moore, Jen Burke Lefever, Kathy Guajardo
    Abstract:

    Obesity rates in the U.S. for both children and adults are alarmingly high, particularly for those in low-income households. The current project, a partnership between Elkhart and St. Joseph Counties Head Start Consortium and the University of Notre Dame’s William J. Shaw Center for Children and Families, focused on reducing obesogenic home environments for low-income families. Focusing on home environments, particularly for young children, is important because research shows that mothers are…

    Date Created:
    2017-10-31
    Resource Type
    Report
  • Creator(s):
    Edward Beatty
    Description:

    The Mexican patent database collects data on all patents issued in Mexico from roughly 1840 to the onset of the Mexican Revolution in 1911, totaling approximately thirteen thousand five hundred (13,500) discrete patent records. At present, this is the most comprehensive record of patents issued by Mexican governments during the nineteenth century. There is no single archival or published source that contains a comprehensive list or data on Mexican patents issued over the course of the long …

    Date Created:
    2018-01-29
  • Creator(s):
    Eitan Tzelgov, Daniel Pemstein, Adam Glynn, Svend-Erik Skaaning, Jeffrey Staton, Allen Hicken, Michael Bernhard, John Gerring, Jan Teorell, Michael Coppedge, Kelly McMann, Megan Reif, Carl Henrik Knutsen, Yi-ting Wang, David Altman, Staffan I. Lindberg, Matthew Kroenig, M. Steven Fish
    Description:

    Data for Varieties of Democracy Project. Version 7 of these files. There is also a collection of posterior files for v.7.

    Date Created:
    2017
  • Author(s):
    Robert Johansen, Alexander Dukalskis
    Abstract:

    Developing normative indicators to measure governments’ consent to, compliance with, and promotion of international laws prohibiting genocide, war crimes, crimes against humanity, and other norms constituting the International Criminal Court (ICC) demonstrates that it is possible to calibrate variation in state conduct over time and to compare one state to another. The indicators make compliance more visible and amenable, both to encouragement by nongovernmental organizations and states, and …

    Date Published:
    2013
  • Creator(s):
    Jan Teorell, Matthew Kroenig, Allen Hicken, Megan Reif, M. Steven Fish, Svend-Erik Skaaning, Adam Glynn, Carl Henrik Knutsen, Kelly McMann, Daniel Pemstein, David Altman, Michael Bernhard, Michael Coppedge, John Gerring, Jeffrey Staton, Eitan Tzelgov, Staffan I. Lindberg, Yi-ting Wang
    Description:

    Posterior data of Higher Level Indices for Varieties of Democracy v.7. The code book and description of the variables can be found in the main item for this collection.

    Date Created:
    2017