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  • Author:
    Matthew R. Kemnetz
    Advisory Committee:
    Flint Thomas, Stanislav V. Gordeyev, Eric J. Jumper, Thomas Juliano
    Degree Area:
    Aerospace and Mechanical Engineering
    Degree:
    Doctor of Philosophy
    Defense Date:
    2019-07-19
  • Author:
    Xi Tan
    Advisory Committee:
    David B. Go, Seong-kyun Im, Sylwia Ptasinska, Zhangli Peng
    Degree Area:
    Aerospace and Mechanical Engineering
    Degree:
    Doctor of Philosophy
    Defense Date:
    2019-04-18
  • Author:
    Francisco A. Herrera Gallegos
    Advisory Committee:
    Tengfei Luo, Seong-Kyun Im, Jason C. Hicks, David B. Go
    Degree Area:
    Aerospace and Mechanical Engineering
    Degree:
    Doctor of Philosophy
    Defense Date:
    2019-03-27
  • Author:
    Xingfei Wei
    Advisory Committee:
    Tengfei Luo, Bill Goodwine, Daniel Gezelter, Zhangli Peng
    Degree Area:
    Aerospace and Mechanical Engineering
    Degree:
    Doctor of Philosophy
    Defense Date:
    2019-02-19
  • Author(s):
    Yide Zhang
    Abstract:

    In cancer and all biomedical researches, we always need a microscope with better imaging precision, speed, functionality, and depth, so that the diagnostics and treatments of cancer and other diseases can be accurate, fast, and noninvasive. However, conventional fluorescence microscopes cannot satisfy these needs due to physical limits on resolution, speed, information, and depth. In this work, we aim to overcome these limits using novel super-resolution microscopy and high-speed quantitative…

    Date Created:
    2018-04-09
    Resource Type
    Presentation
  • Author(s):
    Bradley Ellis, Aylin Acun, U. Isik Can, Pinar Zorlutuna
    Abstract:

    The heart wall tissue, or the myocardium, is one of the main targets in cardiovascular disease prevention and treatment. Animal models have not been sufficient in mimicking the human myocardium as evident by the very low clinical translation rates of cardiovascular drugs. Additionally, current in vitro models of the human myocardium possess several shortcomings such as lack of physiologically relevant co-culture of myocardial cells, lack of a 3D biomimetic environment, and the use of non-huma…

    Date Published:
    2017-03
  • Author(s):
    Shirou Lou, Jarrod Schiffbauer, Tengfei Lou
    Abstract:

    In this work, the droplet size in a water-in-oil emulsion obtained by supersaturation is studied. The emulsion is obtained by cooling down a saturated water/oil solution by a certain temperature difference. The effects of the cooling rate and temperature difference on the produced droplet size are experimentally investigated. The average size of water droplets in the emulsion is found to be proportional to the square root of the cooling rate. By analyzing the time scales of three different st…

    Date Published:
    2017-10
  • Author(s):
    Yide Zhang, Prakash Nallathamby, Genevieve D. Vigil, Aamir A. Khan, Devon E. Mason, Joel D. Boerckel, Ryan K. Roeder, Scott S. Howard
    Abstract:

    Super-resolution fluorescence microscopy is an important tool in biomedical research for its ability to discern features smaller than the diffraction limit. However, due to its difficult implementation and high cost, the super-resolution microscopy is not feasible in many applications. In this paper, we propose and demonstrate a saturation-based super-resolution fluorescence microscopy technique that can be easily implemented and requires neither additional hardware nor complex post-processin…

    Date Published:
    2018-04
  • Author(s):
    Cody E. Narcisco, Nicholas M. Contento, Thomas J. Storey, David J. Hoelzle, Jeremiah J. Zartman
    Abstract:

    Mechanical forces are critical but poorly understood inputs for organogenesis and wound healing. Calcium ions (Ca2+) are critical second messengers in cells for integrating environmental and mechanical cues, but the regulation of Ca2+ signaling is poorly understood in developing epithelial tissues. Here we report a chip-based regulated environment for microorgans that enables systematic investigations of the crosstalk between an organ’s mechanical stress environment and biochemical signaling …

    Date Published:
    2017-07
  • Author:
    Shirui Luo
    Advisory Committee:
    Zhangli Peng, Hsueh-Chia Chang, Tengfei Luo, Gretar Tryggvason
    Degree Area:
    Aerospace and Mechanical Engineering
    Degree:
    PhD
    Defense Date:
    2018-07-02
  • Author:
    Eredzhep Menumerov
    Advisory Committee:
    Svetlana Neretina
    Degree Area:
    Aerospace and Mechanical Engineering
    Degree:
    PhD
    Defense Date:
    2018-05-07
  • Author:
    Anne L Tufts
    Advisory Committee:
    Flint Thomas, Meng Wang, Scott Morris, Aleksandar Jemcov
    Degree Area:
    Aerospace and Mechanical Engineering
    Degree:
    PhD
    Defense Date:
    2018-04-03