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  • Author(s):
    Zhihong Pen, Trung T. Nguyen
    Abstract:

    Diabetic foot ulcers (DFUs) are a common complication of diabetes that are recalcitrant to healing due to persistent inflammation. The majority of DFUs have bacterial biofilms, with Staphylococcus epidermidis as a predominant bacterium, requiring infection control with antibiotics before treatment of the wound. Matrix metalloproteinases (MMPs) play roles in the pathology and repair of DFUs. However, defining the roles of the 24 human MMPs has been challenging due to the presence of three form…

    Date Published:
    2020-09
    Record Visibility:
    Public
  • Author(s):
    Gozde Basara, Mortaza Saeidi-Javash, Xiang Ren, Godhan Bahcecioglu, Brian C. Wyatt, Babak Anasori, Yanliang Zhang, Pinar Zorlutuna
    Abstract:

    Tissue engineered cardiac patches have great potential as a therapeutic treatment for myocardial infarction (MI). However, for successful integration with the native tissue and proper function of the cells comprising the patch, it is crucial for these patches to mimic the ordered structure of the native extracellular matrix and the electroconductivity of the human heart. In this study, a new composite construct that can provide both conductive and topographical cues for human induced pluripot…

    Date Published:
    2020-12
    Record Visibility:
    Public
  • Author(s):
    Allison Young, Carlysa Oyama, Alejandro ClaureDeLaZerda, Yueying Liu, Matthew J. Ravosa, Vijayalaxmi Gupta, Andrea Jewell, Dineo Khabele, M. Sharon Stack
    Abstract:

    The majority of women with recurrent ovarian cancer (OvCa) develop malignant ascites with volumes that can reach > 2 L. The resulting elevation in intraperitoneal pressure (IPP), from normal values of 5 mmHg to as high as 22 mmHg, causes striking changes in the loading environment in the peritoneal cavity. The effect of ascites-induced changes in IPP on OvCa progression is largely unknown. Herein we model the functional consequences of ascites-induced compression on ovarian tumor cells and…

    Date Published:
    2020-04
    Record Visibility:
    Public
  • Author(s):
    Mikala Narlock, Daniel Johnson, Julie Vecchio
    Abstract:

    As academic library support services for digital scholarship activities continue to expand and evolve, large volumes of digital outputs have been created by, and in collaboration with, library and information professionals who are affiliated with digital scholarship centers. Drawing on a literature review and a 2018 pilot study of digital preservation services in digital scholarship centers, we propose future directions for investigation of preservation services for digital scholarship and pr…

    Date Published:
    2021-05
    Record Visibility:
    Public
  • Author(s):
    Mikala Narlock, Abby Shelton
    Abstract:

    Museums, archives, and libraries steward similar materials, yet the design and user experience conventions for online access platforms differ greatly. Presenters will discuss their efforts to design and build a collaborative digital collection site, including a user experience assessment to balance balancing community needs with discipline-specific interface customizations.

    Date Created:
    2021-02-22
    Record Visibility:
    Public
    Resource Type
    Presentation
  • Abstract:

    The University of Notre Dame has been awarded a one-year Institute of Museum and Library Services (IMLS) planning grant to assess the need for library-based machine learning and natural language processing tools to facilitate automated metadata creation and classification in support of cross-disciplinary discovery and research. These are the final outputs of the grant archived for preservation purposes. These materials are also accessible on the related OSF repository: https://osf.io/tmxqf/. …

    Record Visibility:
    Public
    Resource Type
    Document
  • Author(s):
    Mikala Narlock, Peggy Griesinger
    Abstract:

    In the article, the authors discuss the process of creating and revising a prioritization rubric created to help compare digital collections while generating stakeholder buy-in. The rubric is currently a low-tech solution to help educate Hesburgh Library stakeholders on the intricacies of digital collections and gather support for the strategic direction of our collection building. This work builds on previous presentations and publications about the Digital Collections Oversight Team at Hesb…

    Date Published:
    2021-01
    Record Visibility:
    Public
  • Author(s):
    Din Syafruddin, Puji B. S. Asih, Ismail Ekoprayitno Rozi, Dendi Hadi Permana, Anggi Puspa Nur Hidayati, Lepa Syahrani, Siti Zubaidah, Dian Sidik, Michael J. Bangs, Claus Bøgh, Fang Liu, Evercita C. Eugenio, Jared Hendrickson, Timothy Burton, J. Kevin Baird, Frank Collins, John P. Grieco, Neil F. Lobo, Nicole L. Achee
    Abstract:

    A cluster-randomized, double-blinded, placebo-controlled trial was conducted to estimate the protective efficacy (PE) of a spatial repellent (SR) against malaria infection in Sumba, Indonesia. Following radical cure in 1,341 children aged ³ 6 months to £ 5 years in 24 clusters, households were given transfluthrin or placebo passive emanators (devices designed to release vaporized chemical). Monthly blood screening and biweekly human-landing mosquito catches were performed during a 10-month ba…

    Date Published:
    2020
    Record Visibility:
    Public
  • Creator(s):
    Varun Mannam
    Description:

    We created a small dataset - the diffraction limited to super-resolution (DL2SR) dataset - that is dedicated to estimate the super-resolution intensity from a diffracton limited fluorescence microscopy intensity images. The dataset consists of training and testing parts. 15 FOV’s of BPAE cells fluorescence microscopy intensity images obtained with custom-built two-photon microscope. We use 1 FOV DL images for testing. These images are captured with excitation wavelength of 800 nm and powe…

    Date Created:
    2021-02-09
    Record Visibility:
    Public
  • Author(s):
    Alasdair MacIntyre
    Abstract:

    Alasdair MacIntyre is one of the few professional philosophers whose writings span both technical analytical philosophy and those general moral or intellectual questions that laymen often suppose to be the province of philosophy but that are seldom discussed within its bounds. The unity of this book—made up both of original and previously published pieces—lies in its attempt to expose this dichotomy and to link beliefs and moral theories with philosophical criticism. The author successively c…

    Date Created:
    2018-01-01
    Record Visibility:
    Public
    Resource Type
    Book
  • Creator(s):
    Tracy Kijewski-Correa
    Description:

    A recent report suggests that for every $1 spent on natural hazard mitigation measures for homes and businesses, society will on average benefit $6 in avoided direct and direct losses. As the political will is generally lacking to mandate and enforce building code revisions that would require owners in earthquake and hurricane zones to make such investments, these considerable economic and societal benefits will only be realized by discovering what would persuade building owners, and especial…

    Date Created:
    2021-02-02
    Record Visibility:
    Public
  • Author:
    Zhuoyue You
    Advisory Committee:
    Mary M. Keys
    Degree Area:
    Political Science
    Degree:
    Doctor of Philosophy
    Defense Date:
    2021-01-26
    Record Visibility:
    Public