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  • Author(s):
    Patrick Milhoan
    Abstract:

    Over the past 20 years, the creation of databases of digitized climate records have made invaluable resources available to study climate change. Beginning in 2000, NOAA’s Climate Database Modernization Program digitized climate related records resulting in the creation of 56 million climate-related images. The Climatological Database for the World’s Oceans (CLIWOC) project digitized and transcribed ships’ logbooks that recorded weather data during their voyages. These entries provide rese…

    Date Created:
    2019-06-19
    Record Visibility:
    Public
    Resource Type
    Presentation
  • Author(s):
    Hyein Do, Seung-Ryong Kwon, Seol Baek, Chinedu Madukoma, Marina Smiley, Lars Dietrich, Joshua Shrout, Paul Bohn
    Abstract:

    The opportunistic pathogen Pseudomonas aeruginosa (P. aeruginosa) produces several redox-Active phenazine metabolites, including pyocyanin (PYO) and phenazine-1-carboxamide (PCN), which are electron carrier molecules that also aid in virulence. In particular, PYO is an exclusive metabolite produced by P. aeruginosa, which acts as a virulence factor in hospital-Acquired infections and is therefore a good biomarker for identifying early stage colonization by this pathogen. Here, we describe the…

    Date Published:
    2021-01
    Record Visibility:
    Public
  • Author(s):
    Hyein Do, Seung-Ryong Kwon, Seol Baek, Chinedu S. Madukoma, Marina Smiley, Lars Dietrich, Joshua Shrout, Paul Bohn
    Abstract:

    The opportunistic pathogen Pseudomonas aeruginosa (P. aeruginosa) produces several redox-Active phenazine metabolites, including pyocyanin (PYO) and phenazine-1-carboxamide (PCN), which are electron carrier molecules that also aid in virulence. In particular, PYO is an exclusive metabolite produced by P. aeruginosa, which acts as a virulence factor in hospital-Acquired infections and is therefore a good biomarker for identifying early stage colonization by this pathogen. Here, we describe the…

    Date Published:
    2021-01
    Record Visibility:
    Public
  • Author(s):
    Mikala Narlock
    Abstract:

    This presentation was provided for the “Moment to see, Courage to act” initiative led by the Provost’s Office. This presentation focuses on the Marble project, a grant-funded initiative to build a unified discovery and exhibition platform for the Snite Museum of Art and the Hesburgh Libraries.

    Background from the Provost’s Office: And the reality of course is that the challenges will likely continue. We can end up wherever these challenges toss us. Alternatively, we can dec…

    Date Created:
    2021-04-13
    Record Visibility:
    Public
    Resource Type
    Presentation
  • Author(s):
    Lauren Ajamie, Melissa Harden
    Abstract:

    This article presents a case study in which one library designated Product Owners to steer a website redesign project. The Product Owner, commonly used in agile approaches to software development, plays an important leadership role in the development process. In the case described here, two faculty librarians were selected to co-lead the project. This article outlines the benefits of using Product Owners and the factors that led to the two librarians being put on the project. The authors exp…

    Date Published:
    2021-04
    Record Visibility:
    Public
  • Author(s):
    Paul Bohn
    Abstract:

    We present the results of acid-base experiments performed at the single ion (H+ or OH-) limit in ∼6 aL volume nanopores incorporating electrochemical zero-mode waveguides (E-ZMWs). At pH 3 each E-ZMW nanopore contains ca. 3600H+ ions, and application of a negative electrochemical potential to the gold working electrode/optical cladding layer reduces H+ to H2, thereby depleting H+ and increasing the local pH within the nanopore. The change in pH was quantified by tracking the intensity of fluo…

    Date Published:
    2020-09
    Record Visibility:
    Public
  • Author(s):
    Seol Baek, Seung-Ryong Kwon, Kaiyu Fu, Paul Bohn
    Abstract:

    NEA nanopores. Such selectively transported and confined ions are detected by using a 100 nm gap dual-ring nanoelectrode structure capable of enhancing current output by efficient redox cycling with an amplification factor >102. In addition, BCP@NEAs exhibit extraordinary pH-gated ion selectivity, resulting in a 3380-fold current difference between anion and cation probes at pH 3.0. This hierarchically organized BCP-gated NEA system can serve as a template for the development of other stim…

    Date Published:
    2020-11
    Record Visibility:
    Public
  • Author(s):
    Nada Salem Alakhras, Jaeho Shin, Scott S. Smith, Basar Bilgicer, Mark H. Kaplan
    Abstract:

    Link to this article: https://www.jimmunol.org/content/204/1_Supplement/66.9

    Anaphylaxis to peanut allergen is a severe hypersensitive allergic reaction characterized by life-threatening symptoms. Anaphylaxis is mediated by IgE-dependent mast cell activation that leads to the release of inflammatory mediators. In a previous report, we described the design of a covalent heterobivalent inhibitor (cHBI) that selectively forms covalent bonds with allergen specific-IgE (sIgE) on mast cells and ab…

    Date Published:
    2020-05
    Record Visibility:
    Public
  • Author(s):
    Jesus A Alonso, Nishant K Singh, David M Kranz, Brian D Evavold, Brian M Baker
    Abstract:

    Link to this article: https://www.jimmunol.org/content/204/1_Supplement/80.2

    Heterodimeric alpha-beta T cell receptors (TCRs) play a key role in cell-mediated immune responses of adaptive immunity. T cells continuously probe peptides presented by major histocompatibility complex (MHC) found on the cell surface. T cell activation initiates through the binding of antigenic peptides on MHCs. Yeast display technology has proven an effective way to gain insight into the underpinnings of peptide-M…

    Date Published:
    2020-05
    Record Visibility:
    Public
  • Author(s):
    Mariam M George, Cory A Brennick, Marmar M Moussa, Adam T Hagymasi, Sahar Al Seesi, Tatiana V Shcheglova, Ryan P Englander, Grant L.J Keller, Jeremy L Balsbaugh, Brian M Baker, Ion I. Mandoiu, Pramod K Srivastava
    Abstract:

    Link to article: https://www.jimmunol.org/content/204/1_Supplement/239.18

    Cancer neoepitopes are the only truly tumor-specific antigens and therefore, the most suitable as cancer vaccines. Current methods to predict neoepitopes, based on studies of viral epitopes, emphasize high affinity MHC-peptide interactions. Increasing evidence in human and murine models indicates that the present neoepitope prediction methods are mostly inaccurate in predicting true MHC I-restricted cancer neoepitopes….

    Date Published:
    2020-05
    Record Visibility:
    Public
  • Author:
    Samantha Sherman
    Advisory Committee:
    Jonathan D. Hauenstein
    Degree Area:
    Applied and Computational Mathematics and Statistics
    Degree:
    Doctor of Philosophy
    Defense Date:
    2021-03-24
    Record Visibility:
    Public
  • Author(s):
    Shikang Liu, David Hachen, Omar Lizardo, Christian Poellabauer, Aaron Striegel, Tijana Milenković
    Abstract:

    Free PMC Article located at: https://pubmed.ncbi.nlm.nih.gov/31797634/

    Precision medicine has received attention both in and outside the clinic. We focus on the latter, by exploiting the relationship between individuals’ social interactions and their mental health to predict one’s likelihood of being depressed or anxious from rich dynamic social network data. Existing studies differ from our work in at least one aspect: they do not model social interaction data as a network; they do …

    Date Published:
    2020
    Record Visibility:
    Public