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  • Author(s):
    Sangnam Kim, Siyuan Zhang, Sangpil Yoon
    Abstract:

    Current advances in ultrasound imaging techniques combined with the next generation contrast agents such as gas vesicles (GV) revolutionize the visualization of biological tissues with spatiotemporal precision. In optics, fluorescent proteins enable understanding of molecular and cellular functions in biological systems due to their multiplexed imaging capability. Here, a panel of GVs is investigated using mid-band fit (MBF) spectral imaging to realize multiplexed ultrasound imaging to unique…

    Date Created:
    2022-08-11
    Record Visibility:
    Public
  • Author(s):
    Yide Zhang, Yinhao Zhu, Evan Nichols, Qingfei Wang, Vignesh Sundaresan, Siyuan Zhang, Cody Smith, Paul W. Bohn, Scott S. Howard
    Abstract:

    Fluorescence microscopy imaging speed is fundamentally limited by the measurement signal-to-noise ratio (SNR). To improve image SNR for a given image acquisition rate, computational denoising techniques can be used to suppress noise.However, common techniques to estimate a denoised image froma single frame either are computationally expensive or rely on simple noise statistical models. These models assume Poisson or Gaussian noise statistics, which are not appropriate for many fluorescence mi…

    Date Published:
    2022-03
    Record Visibility:
    Public
  • Author(s):
    Brant D. Gates, Jackson B. Vyletel, Lei Zou, Matthew Webber
    Abstract:

    The affinity possible from certain supramolecular motifs rivals that for some of the best-recognized interactions in biology. Cucurbit [7] uril (CB[7]) macrocycles, for example, are capable of achieving affinities in their binding to certain guests that rival that of biotin−avidin. Supramolecular host−guest recognition between CB[7] and certain guests has been demonstrated to spatially localize guest-linked agents to desired sites in vivo, offering opportunities to better exploit this affinit…

    Date Published:
    2022-06
    Record Visibility:
    Public
  • Author(s):
    Zhihong Peng, Mohini Mohan Konai, Luis F. Avila-Cobian, Man Wang, Shahriar Mobashery, Mayland Chang
    Abstract:

    Idiopathic pulmonary fibrosis (IPF), a fatal disease characterized by excessive matrix degradation and fibrosis, destroys the lung architecture and results in the inability of the lungs to absorb oxygen. The cause(s) of IPF is unknown and current treatments are palliative. Matrix metalloproteinases (MMPs) and A Disintegrin And Metalloproteinases (ADAMs) likely play roles in IPF progression. However, specific MMPs and ADAMs in IPF have not been identified due to challenges in MMP/ADAM profilin…

    Date Published:
    2022-03
    Record Visibility:
    Public
  • Author(s):
    Brant D. Gates, Jackson B. Vyletel, Lei Zou, Matthew Webber
    Abstract:

    The affinity possible from certain supramolecular motifs rivals that for some of the best-recognized interactions in biology. Cucurbit [7] uril (CB[7]) macrocycles, for example, are capable of achieving affinities in their binding to certain guests that rival that of biotin−avidin. Supramolecular host−guest recognition between CB[7] and certain guests has been demonstrated to spatially localize guest-linked agents to desired sites in vivo, offering opportunities to better exploit this affinit…

    Date Published:
    2022-06
    Record Visibility:
    Public
  • Author(s):
    L. Gallagher, W. T. Barker, V. B. Hubble, J. Gasper, C. Melander, C. Manoil
    Abstract:

    Small molecule adjuvants that enhance the activity of established antibiotics represent promising agents in the battle against antibiotic resistance. Adjuvants generally act by inhibiting antibiotic resistance processes, and specifying the process acted on is a critical step in defining an adjuvant’s mechanism of action. This step is typically carried out biochemically by identifying molecules that bind adjuvants and then inferring their roles in resistance. Here, we present a complementary g…

    Date Published:
    2022-01
    Record Visibility:
    Public
  • Author(s):
    Parker, R.A.
    Date Published:
    1956
    Record Visibility:
    Public
  • Author(s):
    Sanford, P.R.
    Abstract:

    Analysis of cladoceran fossil remains from sediment cores from two suites of lakes–Tuesday, Paul, and Peter lakes in the Upper Peninsula of Michigan and the Herring River chain of lakes on Cape Cod, Massachusetts–reveals a high incidence of the cornuta form of Bosmina longirostris. This form is characterized by having relatively short, extremely down-curved or down- and out-curved antennules, as opposed to the normal Bosmina morphology of relatively long and slightly curved antennules. Cornut…

    Date Published:
    1993
    Record Visibility:
    Public
  • Author(s):
    McCreary, N.J. and S.R. Carpenter
    Abstract:

    Interspecific and intraspecific interactions were examined in Eleocharis acicularis ( L.) R. & S. and Juncus pelocarpus forma submersus Fassett, two rhizomatous perennial plai;its which occur in the littoral zones of many temperate oligotrophic lakes. Reciprocal replacement series experi­ments were established in Roach Lake, U.S.A., at 4 ratios and 3 densities during the 1982 and 1983 growing seasons. Changes in biomass and in a variety of morphological characters were measured. Although …

    Date Published:
    1987
    Record Visibility:
    Public
  • Author(s):
    Malueg, K.W.
    Date Published:
    1963
    Record Visibility:
    Public
  • Author(s):
    Bade, D. L.
    Date Published:
    2004
    Record Visibility:
    Public
  • Author(s):
    Carpenter, S. R.
    Abstract:

    Blooms of blue-green algae are a serious water quality problem in many productive lakes (Plate 8; Cooke et al. 1986; Paerl 1988). Causes of blue-green blooms involve many factors, including mixing, trace metals, macronutrients, dissolved organic matter, microbial activity, and herbivory (Paerl 1988; Carpenter 1989). Of the many factors implicated, phosphorus loading and grazing are especially pertinent to management of nuisance blue-green blooms (Cooke et al. 1986; Shapiro and Wright 1984). T…

    Date Published:
    1992
    Record Visibility:
    Public