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  • Author(s):
    Ricardo Romer-Moreno, Kimberly Curtis, Thomas Couglin, Maria Mieranda-Vergara, Shourik Dutta, Aishwarya Natarajan, Beth Facchine, Kristen Jackson, Lukas Nystrom, Jun Li, William Kaliney, Glen Niebur, Laurie Littlepage
    Abstract:

    Bone is one of the most common sites for metastasis across cancers. Cancer cells that travel through the vasculature and invade new tissues can remain in a non-proliferative dormant state for years before colonizing the metastatic site. Switching from dormancy to colonization is the rate-limiting step of bone metastasis. Here we develop an ex vivo co-culture method to grow cancer cells in mouse bones to assess cancer cell proliferation using healthy or cancer-primed bones. Profiling soluble f…

    Date Published:
    2019-07
    Record Visibility:
    Public
  • Author(s):
    Ricardo Romer-Moreno, Kimberly Curtis, Thomas Couglin, Maria Mieranda-Vergara, Shourik Dutta, Aishwarya Natarajan, Beth Facchine, Kristen Jackson, Lukas Nystrom, Jun Li, William Kaliney, Glen Niebur, Laurie Littlepage
    Abstract:

    Bone is one of the most common sites for metastasis across cancers. Cancer cells that travel through the vasculature and invade new tissues can remain in a non-proliferative dormant state for years before colonizing the metastatic site. Switching from dormancy to colonization is the rate-limiting step of bone metastasis. Here we develop an ex vivo co-culture method to grow cancer cells in mouse bones to assess cancer cell proliferation using healthy or cancer-primed bones. Profiling soluble f…

    Date Published:
    2019-07
    Record Visibility:
    Public
  • Author(s):
    Holly Weiss-Bilka, Matthew Meagher, Joshua Gargac, Glen Niebur, Ryan Roeder, Diane Wagner
    Abstract:

    Background: Collagen-based scaffolds reinforced with hydroxyapatite (HA) are an attractive choice for bone tissue engineering because their composition mimics that of bone. We previously reported the development of compression-molded collagen-HA scaffolds that exhibited high porosity, interconnected pores, and mechanical properties that were well-suited for surgical handling and fixation. The objective of this study was to investigate these novel collagen-HA scaffolds in combination with huma…

    Date Published:
    2019-07
    Record Visibility:
    Public