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  • Author(s):
    Ricardo Romer-Moreno, Kimberly Curtis, Thomas Couglin, Maria Mieranda-Vergara, Shourik Dutta, Aishwarya Natarajan, Beth Facchine, Kristen Jackson, Lukas Nystrom, Jun Li, William Kaliney, Glen Niebur, Laurie Littlepage
    Abstract:

    Bone is one of the most common sites for metastasis across cancers. Cancer cells that travel through the vasculature and invade new tissues can remain in a non-proliferative dormant state for years before colonizing the metastatic site. Switching from dormancy to colonization is the rate-limiting step of bone metastasis. Here we develop an ex vivo co-culture method to grow cancer cells in mouse bones to assess cancer cell proliferation using healthy or cancer-primed bones. Profiling soluble f…

    Date Published:
    2019-07
    Record Visibility:
    Public
  • Author(s):
    Ricardo Romer-Moreno, Kimberly Curtis, Thomas Couglin, Maria Mieranda-Vergara, Shourik Dutta, Aishwarya Natarajan, Beth Facchine, Kristen Jackson, Lukas Nystrom, Jun Li, William Kaliney, Glen Niebur, Laurie Littlepage
    Abstract:

    Bone is one of the most common sites for metastasis across cancers. Cancer cells that travel through the vasculature and invade new tissues can remain in a non-proliferative dormant state for years before colonizing the metastatic site. Switching from dormancy to colonization is the rate-limiting step of bone metastasis. Here we develop an ex vivo co-culture method to grow cancer cells in mouse bones to assess cancer cell proliferation using healthy or cancer-primed bones. Profiling soluble f…

    Date Published:
    2019-07
    Record Visibility:
    Public
  • Author(s):
    Kimberly Curtis, Thomas Coughlin, Mary Varsanik, Glen Niebur
    Abstract:

    Introduction: Mechanical stimulation of bone is necessary to maintain its mass and architecture. Osteocytes within the mineralized matrix are sensors of mechanical deformation of the hard tissue, and communicate with cells in the marrow to regulate bone remodeling. However, marrow cells are also subjected to mechanical stress during whole bone loading, and may contribute to mechanically regulated bone physiology. Previous results from our laboratory suggest that mechanotransduction in marrow …

    Date Published:
    2019-08
    Record Visibility:
    Public
  • Author(s):
    Kimberly Curtis, Alyssa Oberman, Glen Niebur
    Abstract:

    Bone marrow is a cellular tissue that forms within the pore space and hollow diaphysis of bones. As a tissue, its primary function is to support the hematopoietic progenitor cells that maintain the populations of both erythroid and myeloid lineage cells in the bone marrow, making it an essential element of normal mammalian physiology. However, bone’s primary function is load bearing, and deformations induced by external forces are transmitted to the encapsulatedmarrow.Understanding the effect…

    Date Published:
    2019-08
    Record Visibility:
    Public
  • Author(s):
    Holly Weiss-Bilka, Matthew Meagher, Joshua Gargac, Glen Niebur, Ryan Roeder, Diane Wagner
    Abstract:

    Background: Collagen-based scaffolds reinforced with hydroxyapatite (HA) are an attractive choice for bone tissue engineering because their composition mimics that of bone. We previously reported the development of compression-molded collagen-HA scaffolds that exhibited high porosity, interconnected pores, and mechanical properties that were well-suited for surgical handling and fixation. The objective of this study was to investigate these novel collagen-HA scaffolds in combination with huma…

    Date Published:
    2019-07
    Record Visibility:
    Public
  • Author(s):
    Maria Cristina Miranda-Vergara, Shourik Dutta, Aishwarya Natarajan, Beth Facchine, Kristen Jackson, Lukas Nystrom, Jun Li, William Kaliney, Glen Niebur, Laurie Littlepage
    Abstract:

    Bone is one of the most common sites for metastasis across cancers. Cancer cells that travel through the vasculature and invade new tissues can remain in a non-proliferative dormant state for years before colonizing the metastatic site. Switching from dormancy to colonization is the rate-limiting step of bone metastasis. Here we develop an ex vivo co-culture method to grow cancer cells in mouse bones to assess cancer cell proliferation using healthy or cancer-primed bones. Profiling soluble f…

    Record Visibility:
    Public
  • Author(s):
    Ian M. Sander, Matthew T. McGoldrick, My N. Helms, Aislinn Betts, Anthony van Avermaete, Elizabeth Owers, Evan Doney, Taimi Liepert, Glen Niebur, Douglas Liepert, W. Matthew Leevy
    Abstract:

    Advances in three-dimensional (3D) printing allow for digital files to be turned into a “printed” physical product. For example, complex anatomical models derived from clinical or pre-clinical X-ray computed tomography (CT) data of patients or research specimens can be constructed using various printable materials. Although 3D printing has the potential to advance learning, many academic programs have been slow to adopt its use in the classroom despite increased availability of the equipment …

    Date Published:
    2017
    Record Visibility:
    Public