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  • Author(s):
    Jason Mason, Jordan A. Cockfield, Daniel Pape, Hannah Meissner, Michael Sokolowski, Taylor C. White, Jose Valentin Lopez, Juan Liu, Xiaojing Liu, Inmaculada martinez-Reyes, Navdeep Chandel, Jason Locasale, Zachary Schafer
    Abstract:

    Loss of integrin-mediated attachment to extracellular matrix (ECM) proteins can trigger a variety of cellular changes that impact cell viability. Foremost among these is the activation of anoikis, caspase-mediated cell death induced by ECM-detachment. In addition to anoikis, loss of ECM-attachment causes profound alterations in cellular metabolism that can lead to anoikis-independent cell death. Here, we describe a surprising role for serum and glucocorticoid kinase-1 (SGK1) in the promotion …

    Date Published:
    2020-03
    Record Visibility:
    Public
  • Author(s):
    Frederik J. Steyn, Siobhan Kirk, Tesfay W. Tefera, Teresa Xie, Timothy Tracey, Dean Kelk, Elyse Wimberger, Fleur Garton, Llion Robets, Sarah Chapman, Jeff Coombes, W. Matthew Leevy, Alberto Ferri, Cristiana Valle, Frederique Rene, Jean-Philippe Loeffler, Pamela McCombe, Robert Henderson, Shyuan Ngo
    Abstract:

    Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of upper and lower 36 motor neurons, yet an increasing number of studies in both mouse models and patients with 37 ALS suggest that altered metabolic homeostasis is a feature of disease. Pre-clinical and clinical 38 studies have shown that modulation of energy balance can be beneficial in ALS. However, our 39 capacity to target specific metabolic pathways or mechanisms requires detailed understanding 40 of metabolic dysr…

    Date Published:
    2020-04
    Record Visibility:
    Public
  • Author(s):
    Pavel A. Brodkiy, Qinfeng Wu, Francisco J. Huizar, Dharsan K. Soundarrajan, Cody Narciso, Megan evis, Ninfamaria Arredondo-Walsh, Jianxu Chen, Peixian Liang, Danny Z. Chen, Jeremiah James Zartman
    Abstract:

    Organ development is driven by a set of patterned inductive signals. However, how these signals are integrated to coordinate tissue patterning is still poorly understood. Calcium ions (Ca2+) are critical signaling components involved in signal integration and are regulated by a core Ca2+ signaling toolkit. Ca2+ signaling encodes a significant fraction of information in cells through both amplitude and frequency-dependent regulation of transcription factors and key regulatory enzymes. A range …

    Date Published:
    2017-09
    Record Visibility:
    Public
  • Author(s):
    Qinfeng Wu, Pavel Aleksandrovich Brodkiy, Francisco Javier Huizar, Jamison John Jangula, Cody Narciso, Megan Kathleen Levis, Teresa Brito-Robinson, Jeremiah J. Zartman
    Abstract:

    Recently, organ-scale intercellular Ca2+ transients (ICTs) were reported in the Drosophila wing disc. However, the functional in vivo significance of ICTs remains largely unknown. Here we demonstrate the in vivo relevance of intercellular Ca2+ signaling and its impact on wing development. We report that Ca2+ signaling in vivo decreases as wing discs mature. Ca2+ signaling ex vivo responds to fly extract in a dose-dependent manner. This suggests ICTs occur in vivo due to chemical stimulus that…

    Date Published:
    2017-09
    Record Visibility:
    Public
  • Author(s):
    Christopher D. Kagelman, Devon E. Mason, James H. Dawahare, Genevieve D. Vigil, Scott S. Howard, Teresita M. Bellido, Alexander G. Robling, Joel Boerckel
    Abstract:

    The functions of the transcriptional co-activators YAP and TAZ in bone are controversial. Each has been observed to either promote or inhibit osteogenesis in vitro, while their roles in bone development are unknown. Here we report that combinatorial YAP/TAZ deletion from skeletal cells in mice caused osteogenesis imperfecta with severity dependent on targeted cell lineage and allele dosage. Osteocyte-conditional deletion impaired bone accrual and matrix collagen, while allele dosage-dependent…

    Date Published:
    2017-05
    Record Visibility:
    Public