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  • Author(s):
    Keon R. Schmidt, Barnes Werner, Jenna Koenig, Ian Guldner, Patricia Schnepp, Xuejuan Tan, Lan Jiang, Misha Host, Longhua Sun, Erin Howe, Junmin Wu, Laurie Littlepage, Harikrishna Nakshtri, Siyua Zhang
    Abstract:

    Lacking targetable molecular drivers, triple-negative breast cancer (TNBC) is the most clinically challenging subtype of breast cancer. In this study, we reveal that Death Effector Domain-containing DNA-binding protein (DEDD), which is overexpressed in > 60% of TNBCs, drives a mitogen-independent G1/S cell cycle transition through cytoplasm localization. The gain of cytosolic DEDD enhances cyclin D1 expression by interacting with heat shock 71 kDa protein 8 (HSC70). Concurrently, DEDD inte…

    Date Published:
    2019-07
    Record Visibility:
    Public
  • Author(s):
    Holly Weiss-Bilka, Matthew Meagher, Joshua Gargac, Glen Niebur, Ryan Roeder, Diane Wagner
    Abstract:

    Background: Collagen-based scaffolds reinforced with hydroxyapatite (HA) are an attractive choice for bone tissue engineering because their composition mimics that of bone. We previously reported the development of compression-molded collagen-HA scaffolds that exhibited high porosity, interconnected pores, and mechanical properties that were well-suited for surgical handling and fixation. The objective of this study was to investigate these novel collagen-HA scaffolds in combination with huma…

    Date Published:
    2019-07
    Record Visibility:
    Public
  • Author(s):
    S. Herberg, A. M. McDermott, P. N. Dang, D. S. Alt, R. Tang, J. H. Dawahare, D. Varghai, J-Y. Shin, A. McMillan, A. D. Dikina, F. He, Y. Lee, Y. Cheng, K. Umemori, P. C. Wong, H. Park, J. D. Boerckel, E. Alsberg
    Abstract:

    Endochondral ossification during long bone development and natural fracture healing initiates by mesenchymal cell condensation, directed by local morphogen signals and mechanical cues. Here, we aimed to mimic development for regeneration of large bone defects. We hypothesized that engineered human mesenchymal condensations presenting transforming growth factor–β1 (TGF-β1) and/or bone morphogenetic protein-2 (BMP-2) from encapsulated microparticles promotes endochondral defect regeneration con…

    Record Visibility:
    Public