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  • Inventor(s):
    Jean-Baptiste Thibault, Xue Rui, Somesh Srivastava, Ken D. Sauer, Lin Fu, Charles A. Bouman
    Patent Number:
    US 9261467 B2
    Description:

    A system and method include acquisition of projection data from a scanned object, the set of projection data comprising a plurality of projection measurements. The system and method also include calculation of a set of modified statistical weights from the projection data, wherein a respective modified statistical weight of the set of modified statistical weights comprises a deviation from an inverse variance of a corresponding projection measurement of the projection data. The system and met…

    Date Issued:
    2016-02-16
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Wolfgang Porod, Gary H. Bernstein, Alexei Orlov, Gergo P. Szakmany
    Patent Number:
    US 9577173 B2
    Description:

    Nanoscale thermocouples are made of a single material and are shape-engineered to contain one or more variations in their width along their length. The mono-metallic nanowire junctions resulting from the width variation(s) exploit a difference in the Seebeck coefficient that is present at these size scales. Such devices have a wide variety of uses and can be coupled with an antenna in order to serve as an infrared detector.

    Date Issued:
    2017-02-21
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Olaf G. Wiest, Frederick R. Maxfield, Paul Helquist
    Patent Number:
    US 9333222 B2
    Description:

    Embodiments herein relate to the field of lysosomal storage disorders, and, more specifically, to methods of treating lysosomal storage disorders such as Niemann-Pick type C disease, for instance with inhibitors of histone deacetylases, particularly inhibitors of class 1 histone deacetylases. In various embodiments, methods of treating Niemann-Pick type C disease with inhibitors of class 1 histone deacetylases are described.

    Date Issued:
    2016-05-10
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Crislyn D'Souza-Schorey, James W. Clancy, Vandhana Muralidharan-Chari
    Patent Number:
    US 9329188 B2
    Description:

    The present application relates to the isolation and analysis of populations of microvesicles and the identification of invasive microvesicles in the populations such as populations of microvesicles that are shed by tumor cells. Invasive microvesicles from tumor cells contain a variety of specific proteins, such as ARF6.

    Date Issued:
    2016-05-03
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Jeffrey S. Schorey, Karen M. Dobos
    Patent Number:
    US 9255924 B2
    Description:

    The invention provides methods for the detection of M. tuberculosis proteins in or on exosomes derived from infected individuals. The methods can use a proteomic approach including mass spectroscopy, data mining and multiplex reaction monitoring to quickly examine a large amount of M. tuberculosis proteins to determine the best biomarkers for use in diagnostic tests to identify active TB patients.

    Date Issued:
    2016-02-09
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Douglas C. Hall, Scott Howard, Anthony Hoffman, Gary H. Bernstein, Jason M. Kulick
    Patent Number:
    US 9620473 B1
    Description:

    First and second integrated devices each have an optical component and a plurality of interconnect structures disposed one edge thereon. The first edge surface of the second integrated device is positioned contiguous to the first edge surface of the first integrated device. The interconnect structures disposed on the first integrated device are in physical contact with the interconnect structures disposed on the edge surface of the second integrated device so as to provide alignment for conve…

    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Mark L. La Forest, Allen H. Simpson, Slawomir T. Fryska, Alexander Mukasyan
    Patent Number:
    US 8383197 B2
    Description:

    A metal powder is applied to the surface of the area of a carbon-carbon composite brake disc to be protected against migration of antioxidant. The metal powder may be titanium powder or tungsten powder. A chemical reaction between the metal powder and carbon is then initiated by heating the powder-coated brake to the ignition temperature via application of electric current (Joule preheating) or by heating it in a furnace. Upon combustion, the metal particles react with carbon in the composite…

    Date Issued:
    2013-02-26
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Allen H. Simpson, Slawomir T. Fryska, Mark L. La Forest, Roger L. Klinedinst, Alexander Mukasyan, Charles D. D'Amico
    Patent Number:
    US 8448685 B2
    Description:

    An apparatus for bonding a first carbon composite to a second carbon composite through a reactant layer includes a housing, and a pair of conductive press plates electrically isolated from the housing. The press plates are adapted to position the two parts to be bonded with a reactant layer therebetween. The press plates are subjected to an electrical potential and a clamping force, sufficient to initiate a combustion reaction that creates a molten ceramic to bond together the carbon-carbon c…

    Date Issued:
    2013-05-28
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Ashley P. Thrall, Angelene J. Dascanio, Chad P. Quaglia
    Patent Number:
    US 9,334,645 B2
    Description:

    A shelter has a packaged configuration and a deployed configuration. The shelter has four panels, each with four edges and two faces. The first and fourth panels have a rectangular shape, and the second and third panels have a quadrangle shape. The relationship of panel edge lengths and angles of the quadrangle shelter panels create a sturdy enclosure that is easy to erect, manipulate, and reconfigure. Furthermore, the shelter may be erected by rotating the panels into place via pivotal conne…

    Date Issued:
    May 10, 2016
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Hsueh-Chia Chang, Peter Mushenheim, Sagnik Basuray, Gilad Yossifon, Satyajyoti Senapati
    Patent Number:
    US 8969007 B2
    Description:

    A microchamber electrochemical cell and method of using the cell for performing quantitative analysis of various charged macromolecules is presented. The microchamber electrochemical cell includes a substrate, opposing electrodes and at least one nanoslot. The substrate is configured to define a pair of opposing fluid reservoirs. The pair of opposing electrodes are respectively positioned within the opposing fluid reservoirs. Each nanoslot is configured to fluidly connect the opposing fluid r…

    Date Issued:
    2015-03-03
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Steven Ruggiero, Carol Tanner
    Patent Number:
    US 8867039 B2
    Description:

    Example methods and apparatus for obtaining suspended particle information are disclosed. A disclosed example method includes emitting light from a light source, dividing the light source into a first path and a second path, and directing the first path to a first container comprising a plurality of particles in a suspension material. The example method also includes directing the second path to a second container containing a suspension material devoid of particles, retrieving a first transm…

    Date Issued:
    2014-10-21
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Alan C. Seabaugh, Patrick Fay, Huili (Grace) Xing, Guangle Zhou, Yeqing Lu, Mark A. Wistey, Siyuranga Koswatta
    Patent Number:
    US 8796733 B2
    Description:

    A low voltage tunnel field effect transistor includes a p-n tunnel junction, a gate-dielectric, a gate, a source-contact, and a drain-contact. The p-n tunnel junction includes a depletion region interfacing together a source-layer and a drain-layer. The depletion region includes a source-tunneling-region of the source-layer and a drain-tunneling-region of the drain-layer. When no external electric field is imposed, the depletion region of the p-n tunnel junction has an internal electric field…

    Date Issued:
    2014-08-05
    Record Visibility:
    Public
    Resource Type
    Patent