University of Notre Dame
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- Author(s):
- Peggy Griesinger, Mikala Narlock
- Abstract:
While updating long-standing practices and principles to ensure robust content and metadata for both access and preservation, two case managers from the Libraries’ recently created Digital Content Oversight Team will describe their experience understanding and grappling with issues at the institutional culture level that impact the success of digital projects. (presented at NDSA DigiPres 2019)
- Date Created:
- 2019-10-21
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- Author(s):
- Mikala Narlock, Pat Lawton, Patrick Rader
- Abstract:
At Hesburgh Libraries at the University of Notre Dame, digitization had been an obscure process: roles and responsibilities were unclear, capacity was opaque, and institutional capabilities were mostly unknown. Collections were being digitized, but many were unclear how to go about it and what the possibilities were. Some characterized what had evolved as a “favor-based” system. To resolve these uncertainties, the Digital Collections Workflow (DCW) Team was established and charged with ensuri…
- Date Published:
- 2019-10
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- Author(s):
- Jeff Harden
- Abstract:
Politicians and scholars contend that governmental transparency reforms constrain politicians’ capacity to negotiate and compromise in the pursuit of policy goals. However, existing research primarily emphasizes only that governments are strategic in adopting these reforms; whether lawmakers actually incur the alleged costs of transparency remains an open question. We investigate this issue in the context of American state legislatures, many of which have become exempt from “sunshine…
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- Author(s):
- Brianna Norris-Mullins, Bruce J. Melancon, Miguel A. Morales, Mary Ann McDowell
- Abstract:
Leishmania parasites are the causative agents of a wide spectrum of human diseases. The clinical mani- festations of leishmaniasis range from self-healing skin lesions to fatality. The World Health Organization has classed leishmaniasis as a category 1 neglected tropical disease. Leishmaniasis represents a major in- ternational health challenge, affecting 12 million people per year and with nearly 310 million people at risk. The first-line chemotherapies used to treat leishmaniasis are intrav…
- Date Published:
- 2019-07
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5
Article
- Author(s):
- Maria Cristina Miranda-Vergara, Shourik Dutta, Aishwarya Natarajan, Beth Facchine, Kristen Jackson, Lukas Nystrom, Jun Li, William Kaliney, Glen Niebur, Laurie Littlepage
- Abstract:
Bone is one of the most common sites for metastasis across cancers. Cancer cells that travel through the vasculature and invade new tissues can remain in a non-proliferative dormant state for years before colonizing the metastatic site. Switching from dormancy to colonization is the rate-limiting step of bone metastasis. Here we develop an ex vivo co-culture method to grow cancer cells in mouse bones to assess cancer cell proliferation using healthy or cancer-primed bones. Profiling soluble f…
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- Author(s):
- Ryan Roeder
- Abstract:
Quantitative material decomposition of multiple mixed, or spatially coincident, contrast agent (gadolinium and iodine) and tissue (calcium and water) compositions is demonstrated using photon-counting spectral computed tomography (CT). Material decomposition is performed using constrained maximum like- lihood estimation (MLE) in the image domain. MLE is calibrated by multiple linear regression of all pure material compositions, which exhibits a strong correlation (R2 > 0.91) between the me…
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- Author(s):
- Mikala Narlock, Peggy Griesinger
- Abstract:
Presenters will describe the process of establishing formal project oversight for similar yet unique digital collections and projects. Attendees will be offered an inside look at the low-tech Case Manager approach, including helpful documentation, the variety of roles this process necessitates, and strategies for sustaining the practice.
- Date Created:
- 2019-10-17
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- Author(s):
- J. Schiltz, Andrew Rosenberger, Todd Render, Bernice Aboud Gatrell, Haibo Qu, Colton Steiner, Paul McGinn, Steve Schmid
- Abstract:
Ceramics have exceptional tribological performance in high wear applications, but susceptibility to brittle fracture requires expensive postprocessing, including hot isostatic pressing and polishing. Consequently, additive manufacturing (AM) represents a collection of potentially costsaving approaches for ceramic production. AM technologies have been demonstrated for oxide ceramics, but the performance of self-mated AM materials remains unknown and underscores a critical knowledge gap. Alumin…
- Date Published:
- 2019-06
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- Author(s):
- A. Vania Apkarian, Kasturi Halder, Suhail Alam, Maria Virginia Centeno
- Abstract:
The disclosure relates to use of a triple formulation comprising a histone deacytlase, a cyclodextrin and polyethylene glycol or propylene glycol, and in the treatment and management of chronic pain.
- Date Created:
- 2019-10-15
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- Author(s):
- Pierre C. Dagher, Evan L. Nichols, Cody J. Smith, Kenneth W. Dunn, Scott S. Howard
- Abstract:
Fluorescence lifetime imaging microscopy (FLIM) provides additional contrast for fluorophores with overlapping emission spectra. The phasor approach to FLIM greatly reduces the complexity of FLIM analysis and enables a useful image segmentation technique by selecting adjacent phasor points and labeling their corresponding pixels with different colors. This phasor labeling process, however, is empirical and could lead to biased results. In this Letter, we present a novel and unbiased approach …
- Date Published:
- 2019-08
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- Author(s):
- Yide Zhang, Yinhao Zhu, Evan Nichols, Qingfei Wang, Siyuang Zhang, Cody Smith, Scott Howard
- Abstract:
Fluorescence microscopy has enabled a dramatic development in modern biology. Due to its inherently weak signal, fluorescence microscopy is not only much noisier than photography, but also presented with Poisson-Gaussian noise where Poisson noise, or shot noise, is the dominating noise source. To get clean fluorescence microscopy images, it is highly desirable to have effective denoising algorithms and datasets that are specifically designed to denoise fluorescence microscopy images. While su…
- Date Created:
- 2019-10-15
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12
Article
- Author(s):
- S. Herberg, A. M. McDermott, P. N. Dang, D. S. Alt, R. Tang, J. H. Dawahare, D. Varghai, J-Y. Shin, A. McMillan, A. D. Dikina, F. He, Y. Lee, Y. Cheng, K. Umemori, P. C. Wong, H. Park, J. D. Boerckel, E. Alsberg
- Abstract:
Endochondral ossification during long bone development and natural fracture healing initiates by mesenchymal cell condensation, directed by local morphogen signals and mechanical cues. Here, we aimed to mimic development for regeneration of large bone defects. We hypothesized that engineered human mesenchymal condensations presenting transforming growth factor–β1 (TGF-β1) and/or bone morphogenetic protein-2 (BMP-2) from encapsulated microparticles promotes endochondral defect regeneration con…