University of Notre Dame
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- Author(s):
- Sasha Padilla-Coley, Hui Xu
- Abstract:
hydrophobic (i.e., Hoechst 33342) dyes or drugs, including a binary dye/drug pair (i.e., indocyanine green/mitoxantrone). The core of HBPn, containing a mixture of uncharged 2-pentanone chains and 1,2,3-triazole rings, could be loaded with uncharged and very hydrophobic dyes (i.e., Nile Red) or drugs. Improved aqueous solubility of camptothecin was achieved 10-fold from 8.4 to 75 ng/mL. Additionally, cell toxicity studies showed that HBPn was able to release the camptothecin drug inside A549 …
- Date Published:
- 2020-04
- Record Visibility:
- Public
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2
Doctoral Dissertation
- Author:
- Jinhe Ye
- Advisory Committee:
- Sergei Starchenko
- Degree Area:
- Mathematics
- Degree:
- Doctor of Philosophy
- Defense Date:
- 2020-05-04
- Record Visibility:
- Public
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- Author(s):
- Frederik J. Steyn, Siobhan Kirk, Tesfay W. Tefera, Teresa Xie, Timothy Tracey, Dean Kelk, Elyse Wimberger, Fleur Garton, Llion Robets, Sarah Chapman, Jeff Coombes, W. Matthew Leevy, Alberto Ferri, Cristiana Valle, Frederique Rene, Jean-Philippe Loeffler, Pamela McCombe, Robert Henderson, Shyuan Ngo
- Abstract:
Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of upper and lower 36 motor neurons, yet an increasing number of studies in both mouse models and patients with 37 ALS suggest that altered metabolic homeostasis is a feature of disease. Pre-clinical and clinical 38 studies have shown that modulation of energy balance can be beneficial in ALS. However, our 39 capacity to target specific metabolic pathways or mechanisms requires detailed understanding 40 of metabolic dysr…
- Date Published:
- 2020-04
- Record Visibility:
- Public
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4
Doctoral Dissertation
- Author:
- Mallika S. Sarma
- Advisory Committee:
- Agustín Fuentes, Cara Ocobock, Lee T. Gettler, James J. McKenna
- Degree Area:
- Anthropology
- Degree:
- Doctor of Philosophy
- Defense Date:
- 2020-05-05
- Record Visibility:
- Public
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5
Doctoral Dissertation
- Author:
- Lina Cao
- Advisory Committee:
- Patrick J. Fay
- Degree Area:
- Electrical Engineering
- Degree:
- Doctor of Philosophy
- Defense Date:
- 2020-05-14
- Record Visibility:
- Public
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6
Doctoral Dissertation
- Author:
- Reginald (Brendan) Lynch
- Advisory Committee:
- Joseph P. Wawrykow
- Degree Area:
- Theology
- Degree:
- Doctor of Philosophy
- Defense Date:
- 2020-04-27
- Record Visibility:
- Public
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- Author(s):
- Jeff Harden
- Abstract:
Governments around the world adopt transparency reforms to facilitate accountability. In principle, open proceedings provide citizens with valuable information to evaluate elected officials’ decisionmaking, which incentives lawmakers to follow mass preferences when choosing policies. However, the public’s general lack of knowledge and engagement with the political process may weaken the power of open information, and perhaps instead allow citizens and groups with extreme views to exer…
- Record Visibility:
- Public
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8
Doctoral Dissertation
- Author:
- Robert Wyllie
- Advisory Committee:
- Patrick J. Deneen, Michael P. Zuckert, Dana R. Villa
- Degree Area:
- Political Science
- Degree:
- Doctor of Philosophy
- Defense Date:
- 2019-12-19
- Record Visibility:
- Public
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9
Doctoral Dissertation
- Author:
- Pei Li
- Advisory Committee:
- Patrick J. Flynn
- Degree Area:
- Computer Science and Engineering
- Degree:
- Doctor of Philosophy
- Record Visibility:
- Public
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10
Doctoral Dissertation
- Author:
- Julianne Dolan
- Advisory Committee:
- Jennifer Newsome Martin, Francesca A. Murphy, Cyril J. O'Regan, John Betz
- Degree Area:
- Theology
- Degree:
- Doctor of Philosophy
- Defense Date:
- 2020-03-20
- Record Visibility:
- Public
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11
Doctoral Dissertation
- Author:
- Owen Dominguez
- Advisory Committee:
- Anthony J. Hoffman
- Degree Area:
- Electrical Engineering
- Degree:
- Doctor of Philosophy
- Defense Date:
- 2020-04-17
- Record Visibility:
- Public
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12
Doctoral Dissertation
- Author:
- Michael T. Waldrop
- Advisory Committee:
- Flint O. Thomas
- Degree Area:
- Aerospace and Mechanical Engineering
- Degree:
- Doctor of Philosophy
- Defense Date:
- 2020-02-20
- Record Visibility:
- Public