Search CurateND

Search criteria:

Clear all

List of files deposited in CurateND that match your search criteria

  • Author(s):
    Christopher D. Kagelman, Devon E. Mason, James H. Dawahare, Genevieve D. Vigil, Scott S. Howard, Teresita M. Bellido, Alexander G. Robling, Joel Boerckel

    The functions of the transcriptional co-activators YAP and TAZ in bone are controversial. Each has been observed to either promote or inhibit osteogenesis in vitro, while their roles in bone development are unknown. Here we report that combinatorial YAP/TAZ deletion from skeletal cells in mice caused osteogenesis imperfecta with severity dependent on targeted cell lineage and allele dosage. Osteocyte-conditional deletion impaired bone accrual and matrix collagen, while allele dosage-dependent…

    Date Published:
    Record Visibility: