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• 1

  Article

  Super-resolution fluorescence microscopy by stepwise optical saturation
  

  Author(s):

  Yide Zhang, Prakash Nallathamby, Genevieve D. Vigil, Aamir A. Khan, Devon E. Mason, Joel D. Boerckel, Ryan K. Roeder, Scott S. Howard

  Abstract:

  Super-resolution fluorescence microscopy is an important tool in biomedical research for its ability to discern features smaller than the diffraction limit. However, due to its difficult implementation and high cost, the super-resolution microscopy is not feasible in many applications. In this paper, we propose and demonstrate a saturation-based super-resolution fluorescence microscopy technique that can be easily implemented and requires neither additional hardware nor complex post-processin…

  Date Published:

  2018-04

  Record Visibility:

  Public

• 2

  Article

  Recapitulating bone development for tissue regeneration through engineered mesenchymal condensations and mechanical cues
  

  Author(s):

  Anna M. McDermott, Samuel Herberg, Devon E. Mason, Hope B. Pearson, James H. Dawahare, Joseph M. Collins, Rui Tang, Amit Patwa, Mark W. Grinstaff, Daniel J. Kelly, Eben Alsberg, Joel D. Boerckel

  Abstract:

  Natural fracture healing recapitulates bone development through endochondral ossification, resulting in clinical success rates of 90-95%. However, large bone defects of critical size cannot form a callus and exhibit high rates of complication and non-union even after intervention. Bone tissue engineering holds promise, but traditional approaches have focused on direct, intramembranous bone formation. We propose that mimicking the endochondral process that is naturally selected for bone develo…

  Date Published:

  2017

  Record Visibility:

  Public