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  Article

  Leishmania phosphatase PP5 is a regulator of HSP83 phosphorylation and essential for parasite pathogenicity
  

  Author(s):

  Katheryn L. Smith, Micah J. Ferrell, Miguel A. Morales, Brianna Norris-Mulins, Joseph S. Krivda

  Abstract:

  Leishmania parasites are responsible for important neglected diseases in humans and animals, ranging from self-healing cutaneous lesions to fatal visceral manifestations. During the infectious cycle, Leishmania differentiates from the extracellular flagellated promastigote to the intracellular pathogenic amastigote. Parasite differentiation is triggered by changes in environmental cues, mainly pH and temperature. In general, extracellular signals are translated into stage-specific gene expres…

  Date Published:

  2018-09

  Record Visibility:

  Public