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1
Article
- Author(s):
- Elley Rudebeck, Bradley D. Smith, Frederick M. Pfeffer
- Abstract:
An intracellular fluorescence competition assay was developed to assess the capability of inhibitor candidates to engage histone deacetylase (HDAC) inside living cells and thus diminish cell uptake and staining by the HDACtargeted fluorescent probe APS. Fluorescence cell microscopy and flow cytometry showed that pre-incubation of living cells with candidate inhibitors led to diminished cell uptake of the fluorescent probe. The assay was effective because the fluorescent probe (APS) possessed …
- Date Published:
- 2021-09
- Record Visibility:
- Public
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- Author(s):
- Gozde Basara, Mortaza Saeidi-Javash, Xiang Ren, Godhan Bahcecioglu, Brian C. Wyatt, Babak Anasori, Yanliang Zhang, Pinar Zorlutuna
- Abstract:
Tissue engineered cardiac patches have great potential as a therapeutic treatment for myocardial infarction (MI). However, for successful integration with the native tissue and proper function of the cells comprising the patch, it is crucial for these patches to mimic the ordered structure of the native extracellular matrix and the electroconductivity of the human heart. In this study, a new composite construct that can provide both conductive and topographical cues for human induced pluripot…
- Date Published:
- 2020-12
- Record Visibility:
- Public
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- Author(s):
- Mikala Narlock, Daniel Johnson, Julie Vecchio
- Abstract:
As academic library support services for digital scholarship activities continue to expand and evolve, large volumes of digital outputs have been created by, and in collaboration with, library and information professionals who are affiliated with digital scholarship centers. Drawing on a literature review and a 2018 pilot study of digital preservation services in digital scholarship centers, we propose future directions for investigation of preservation services for digital scholarship and pr…
- Date Published:
- 2021-05
- Record Visibility:
- Public
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- Author(s):
- Mark Robison, Nancy Fawley, Ann Marshall
- Abstract:
Undergraduate students who transfer from one institution to another do so at wildly variant points in their college careers. The range of stages at which students transfer raises questions for librarians who support these students. This article presents the findings from the second phase of a two-phase, multi-campus research project, examining incoming transfer students’ experiences related to research and information literacy (IL) instruction. Grounded in the dual theories of transfer de…
- Date Published:
- 2020-01
- Record Visibility:
- Public
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- Author(s):
- Muhammad Ahmad, Chao Tang, Liu Yang, Andriy Yaroshchuk, Merlin Bruening
- Abstract:
Development of anion-exchange membranes (AEMs) with selectivities among anions may expand the applications of these membranes in salt separations. This work shows that layer-by-layer coating of aliphatic polyamide AEMs with poly(4-styrenesulfonate) (PSS)/protonated poly(allylamine) (PAH) films enhances Cl − /SO 42− dialysis selectivities, and the extent of this enhancement depends on the source-phase salt concentrations. For a source phase containing 0.01 M NaCl and 0.01 M Na 2 SO 4 and a rec…
- Date Published:
- 2019-02
- Record Visibility:
- Public
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- Author(s):
- J. Schiltz, Andrew Rosenberger, Todd Render, Bernice Aboud Gatrell, Haibo Qu, Colton Steiner, Paul McGinn, Steve Schmid
- Abstract:
Ceramics have exceptional tribological performance in high wear applications, but susceptibility to brittle fracture requires expensive postprocessing, including hot isostatic pressing and polishing. Consequently, additive manufacturing (AM) represents a collection of potentially costsaving approaches for ceramic production. AM technologies have been demonstrated for oxide ceramics, but the performance of self-mated AM materials remains unknown and underscores a critical knowledge gap. Alumin…
- Date Published:
- 2019-06
- Record Visibility:
- Public
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- Author(s):
- K. Manukyan, C. Fesano, A. Majumdar, G. Peaslee, M. Raddell
- Abstract:
This work presents results of macro, micro, and nanoscale surface characterization for a set of Roman denarii, ranging from 136 BCE to 240 CE, using large-scale X-ray fluorescence (XRF) mapping, particle-induced X-ray emission (PIXE) spectroscopy, focused-ion-beam-assisted scanning electron microscopy (FIB-SEM) with energy dispersive spectroscopy (EDS). The combination of XRF and PIXE, with varying beam energies, allowed for visualization and quantification of individual elements as a functio…
- Date Created:
- 2019-08-15
- Record Visibility:
- Public
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- Author(s):
- Lisa Irimata, Tracy Vargo-Gogola, Ryan Roeder
- Abstract:
A preclinical murine model of hydroxyapatite (HA) breast microcalcifications (µcals), which are an important clinical biomarker for breast cancer detection, was used to investigate the independent effects of high affinity bisphosphonate (BP) ligands and a polyethylene glycol (PEG) spacer on targeted delivery of gold nanoparticles (Au NPs) for contrast-enhanced radiographic detection. The addition of BP ligands to PEGylated Au NPs (BP-PEG-Au NPs) resulted in five-fold greater binding affinity …
- Date Published:
- 2018
- Record Visibility:
- Public
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- Author(s):
- Yumiko Tokusumi, Tsuyoshi Tokusumi, Robert A. Schulz
- Abstract:
Acute inflammation can cause serious tissue damage and disease in physiologically-challenged organisms. The precise mechanisms leading to these detrimental effects remain to be determined. In this study, we utilize a reproducible means to induce cellular immune activity in Drosophila larvae in response to mechanical stress. That is, forceps squeeze-administered stress induces lamellocytes, a defensive hemocyte type that normally appears in response to wasp infestation of larvae. The posterior…
- Date Published:
- 2018-07
- Record Visibility:
- Public
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- Author(s):
- Jeremy Fein, Clayton Johnson, Joshua Shrout
- Abstract:
Understanding metal sorption to bacteria is important for developing bioremediation strategies, for determining the fate of contaminants in ground water systems, and for defining controls on microbial metabolic processes in the environment. X-ray absorption spectroscopy (XAS) has been the only technique available for quantifying and mapping metal sorption to bacteria on an individual cell scale, but the XAS approach is time consuming and expensive, and quantitative mapping of the distribution…
- Date Published:
- 2018-04
- Record Visibility:
- Public
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- Author(s):
- Manuela Lahne, Clare E. Yarka, Michael E. Petravick, Jingling Li, David R. Hyde
- Abstract:
Sox2 is a well-established neuronal stem cell-associated transcription factor that regulates neural development and adult neurogenesis in vertebrates, and is one of the critical genes used to reprogram differentiated cells into induced pluripotent stem cells. We examined if Sox2 was involved in the early reprogramming-like events that Müller glia undergo as they upregulate many pluripotency- and neural stem cell-associated genes required for proliferation in light-damaged adult zebrafish reti…
- Date Published:
- 2017-08
- Record Visibility:
- Public
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- Author(s):
- Paul T. Kroeger, Bridgette E. Drumond, Rachel Miceli, Michael McKernan, Gary F. Gerlach, Amanda N. Marra, Annemarie Fox, Kristen K. McCampbell, Ignaty Leshchiner, Adriana Rodriguez-Mari, Ruth Bremiller, Ryan Thummel, Alan J. Davidson, John Postlethwait, Wolfram Goessling, Rebecca Wingert
- Abstract:
The zebrafish kidney is conserved with other vertebrates, making it an excellent genetic model to study renal development. The kidney collects metabolic waste using a blood filter with specialized epithelial cells known as podocytes. Podocyte formation is poorly understood but relevant to many kidney diseases, as podocyte injury leads to progressive scarring and organ failure. zeppelin (zep) was isolated in a forward screen for kidney mutants and identified as a homozygous recessive lethal al…
- Date Published:
- 2017
- Record Visibility:
- Public