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- Author(s):
- Peggy Griesinger, Mikala Narlock, Hanna Bertoldi
- Abstract:
This chapter will use the University of Notre Dame’s Marble (Museum, Archives, Rare Books, and Library Exploration platform) project as a useful framework for exploring some ethical cataloging concerns of biographical metadata as they relate to linked data in libraries, archives, and museums (LAM). During the development of this platform, extensive user testing revealed frequent requests for additional information about content creators. While a linked data solution could be deployed to enhan…
- Date Published:
- 2023
- Record Visibility:
- Public
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- Author(s):
- Andrew A. Oliva, Aleksandar Jemcov
- Abstract:
Modeling variable specific heat is a crucial aspect of aerospace engineering, playing a significant role in designing and analyzing high-enthalpy internal and external flows. Moreover, variable specific heat effects are becoming progressively more important with the increasing interest in hypersonic flight, where accurate temperature prediction is critical to determine chemical reaction rates and heat flux. Similarly, the influence of variable specific heat is significant in combustion, where…
- Date Created:
- 2023-09-19
- Record Visibility:
- Public
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- Author(s):
- Jessica Morales, Anastasia Guimaraes
- Abstract:
This chapter offers a glimpse into using an integrated project-management approach to migrate from a legacy homegrown system to a vendor-supported electronic resource management (ERM) system supported by a user community. Regardless of the level of project management adoption at one’s institution, the readers will gain insight into how project management can create great value by efficiently organizing the work, improving communication through intentional planning, and meeting deadlines throu…
- Date Created:
- 2022-08-12
- Record Visibility:
- Public
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- Author(s):
- Bradley D. Smith
- Abstract:
A broad array of imaging and diagnostic technologies employs fluorophore-labeled antibodies for biomarker visualization, an experimental technique known as immunofluorescence. Significant performance advantages, such as higher signal-to-noise ratio, are gained if the appended fluorophore emits near-infrared (NIR) light with a wavelength >700 nm. However, the currently available NIR fluorophore antibody conjugates are known to exhibit significant limitations, including low chemical stabilit…
- Date Published:
- 2021-02
- Record Visibility:
- Public
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5
Article
- Author(s):
- Allen G. Oliver, Bradley D. Smith
- Abstract:
A new supramolecular paradigm is presented for reliable capture and co-precipitation of haloauric acids (HAuX4) from organic solvents or water. Two classes of acyclic organic compounds act as complementary receptors (tectons) by forming two sets of directional non-covalent interactions, (a) hydrogen bonding between amide (or amidinium) NH residues and the electronegative X ligands on the AuX4 @, and (b) electrostatic stacking of the electron deficient Au center against the face of an aromatic…
- Date Published:
- 2020-06
- Record Visibility:
- Public
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- Author(s):
- Dong-Hao Li, Cynthia L. Schreiber, Bradley D. Smith
- Abstract:
The near-infrared window of fluorescent heptamethine cyanine dyes greatly facilitates biological imaging because there is deep penetration of the light and negligible background fluorescence. However, dye instability, aggregation, and poor pharmacokinetics are current drawbacks that limit performance and the scope of possible applications. All these limitations are simultaneously overcome with a new molecular design strategy that produces a charge balanced and sterically shielded fluorochrome…
- Date Published:
- 2020-07
- Record Visibility:
- Public
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- Author(s):
- Canjia Zhai, Cynthia L. Schreiber, Sasha Padilla-Coley, Allen G. Oliver, Bradley D. Smith
- Abstract:
A general synthetic method creates a new class of covalently connected, self-threaded, fluorescent molecular probes with figure-eight topology, an encapsulated deep-red fluorophore, and two peripheral peptide loops. The globular molecular shape and rigidified peptide loops enhance imaging performance by promoting water solubility, eliminating probe self-aggregation, and increasing probe stability. Moreover, the peptide loops determine the affinity and selectivity for targets within complex bi…
- Date Published:
- 2020-01
- Record Visibility:
- Public
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- Author(s):
- Canjia Zhai, Cynthia L. Schreiber, Sasha Padilla-Coley, Allen G. Oliver, Bradley D. Smith
- Abstract:
A general synthetic method creates a new class of covalently connected, self-threaded, fluorescent molecular probes with figure-eight topology, an encapsulated deep-red fluorophore, and two peripheral peptide loops. The globular molecular shape and rigidified peptide loops enhance imaging performance by promoting water solubility, eliminating probe self-aggregation, and increasing probe stability. Moreover, the peptide loops determine the affinity and selectivity for targets within complex bi…
- Date Published:
- 2020-01
- Record Visibility:
- Public
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- Author(s):
- Dong-Hao Li, Cynthia L. Schreiber, Bradley D. Smith
- Abstract:
The near-infrared window of fluorescent heptamethine cyanine dyes greatly facilitates biological imaging because there is deep penetration of the light and negligible background fluorescence. However, dye instability, aggregation, and poor pharmacokinetics are current drawbacks that limit performance and the scope of possible applications. All these limitations are simultaneously overcome with a new molecular design strategy that produces a charge balanced and sterically shielded fluorochrome…
- Date Published:
- 2020-07
- Record Visibility:
- Public
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- Author(s):
- Bradley D. Smith
- Abstract:
Macrocyclic hosts have long been used for guest encapsulation, and recently a new application has emerged; employment as supramolecular elements for capture and recovery of gold through host/guest co-precipitation. The guests are square-planar tetrahaloaurate anions, practically important gold complexes with a capacity to engage in non-covalent interactions such as hydrogen bonding and Au–! interactions. The successful macrocyclic hosts for co-precipitation include cyclodextrins, cucurbituril…
- Date Published:
- 2021-01
- Record Visibility:
- Public
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- Author(s):
- Janeala J. Morsby, Madushani Dharmarwardana, Hannah McGarraugh, Bradley D. Smith
- Abstract:
A tetralactam macrocycle acts as a novel supramolecular adjuvant to capture a released resorufin dye and create a higher contrasting yellow/blue color change for enhanced naked eye interpretation of a colorimetric indicator assay.
- Date Published:
- 2020-07
- Record Visibility:
- Public
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- Author(s):
- Dong-Hao Li, Bradley D. Smith
- Abstract:
Indocyanine Green (ICG) is a clinically approved near-infrared fluorescent dye that is used extensively for various imaging and diagnostic procedures. One drawback with ICG is its instability in water, which means that reconstituted clinical doses have to be used very shortly after preparation. Two deuterated versions of ICG were prepared with deuterium atoms on the heptamethine chain, and the spectral, physiochemical, and photostability properties were quantified. A notable mechanistic findi…
- Date Published:
- 2021-09
- Record Visibility:
- Public