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  • Author(s):
    K. Manukyan, C. Fesano, A. Majumdar, G. Peaslee, M. Raddell
    Abstract:

    This work presents results of macro, micro, and nanoscale surface characterization for a set of Roman denarii, ranging from 136 BCE to 240 CE, using large-scale X-ray fluorescence (XRF) mapping, particle-induced X-ray emission (PIXE) spectroscopy, focused-ion-beam-assisted scanning electron microscopy (FIB-SEM) with energy dispersive spectroscopy (EDS). The combination of XRF and PIXE, with varying beam energies, allowed for visualization and quantification of individual elements as a functio…

  • Author(s):
    Lisa Irimata, Tracy Vargo-Gogola, Ryan Roeder
    Abstract:

    A preclinical murine model of hydroxyapatite (HA) breast microcalcifications (µcals), which are an important clinical biomarker for breast cancer detection, was used to investigate the independent effects of high affinity bisphosphonate (BP) ligands and a polyethylene glycol (PEG) spacer on targeted delivery of gold nanoparticles (Au NPs) for contrast-enhanced radiographic detection. The addition of BP ligands to PEGylated Au NPs (BP-PEG-Au NPs) resulted in five-fold greater binding affinity …

    Date Published:
    2018
  • Author(s):
    Yumiko Tokusumi, Tsuyoshi Tokusumi, Robert A. Schulz
    Abstract:

    Acute inflammation can cause serious tissue damage and disease in physiologically-challenged organisms. The precise mechanisms leading to these detrimental effects remain to be determined. In this study, we utilize a reproducible means to induce cellular immune activity in Drosophila larvae in response to mechanical stress. That is, forceps squeeze-administered stress induces lamellocytes, a defensive hemocyte type that normally appears in response to wasp infestation of larvae. The posterior…

    Date Published:
    2018-07
  • Author(s):
    Jeremy Fein, Clayton Johnson, Joshua Shrout
    Abstract:

    Understanding metal sorption to bacteria is important for developing bioremediation strategies, for determining the fate of contaminants in ground water systems, and for defining controls on microbial metabolic processes in the environment. X-ray absorption spectroscopy (XAS) has been the only technique available for quantifying and mapping metal sorption to bacteria on an individual cell scale, but the XAS approach is time consuming and expensive, and quantitative mapping of the distribution…

    Date Published:
    2018-04
  • Author(s):
    Manuela Lahne, Clare E. Yarka, Michael E. Petravick, Jingling Li, David R. Hyde
    Abstract:

    Sox2 is a well-established neuronal stem cell-associated transcription factor that regulates neural development and adult neurogenesis in vertebrates, and is one of the critical genes used to reprogram differentiated cells into induced pluripotent stem cells. We examined if Sox2 was involved in the early reprogramming-like events that Müller glia undergo as they upregulate many pluripotency- and neural stem cell-associated genes required for proliferation in light-damaged adult zebrafish reti…

    Date Published:
    2017-08
  • Author(s):
    Paul T. Kroeger, Bridgette E. Drumond, Rachel Miceli, Michael McKernan, Gary F. Gerlach, Amanda N. Marra, Annemarie Fox, Kristen K. McCampbell, Ignaty Leshchiner, Adriana Rodriguez-Mari, Ruth Bremiller, Ryan Thummel, Alan J. Davidson, John Postlethwait, Wolfram Goessling, Rebecca Wingert
    Abstract:

    The zebrafish kidney is conserved with other vertebrates, making it an excellent genetic model to study renal development. The kidney collects metabolic waste using a blood filter with specialized epithelial cells known as podocytes. Podocyte formation is poorly understood but relevant to many kidney diseases, as podocyte injury leads to progressive scarring and organ failure. zeppelin (zep) was isolated in a forward screen for kidney mutants and identified as a homozygous recessive lethal al…

    Date Published:
    2017
  • Author(s):
    M. McFadden, J. Loconsole, A. J. Schockling, R. Nerenberg, J. P. .Pavassich
    Abstract:

    Peracetic acid (PAA) is an alternative disinfectant that may be effective for combined sewer overflow (CSO) disinfection, but little is known about the effect of particle size on PAA disinfection efficiency. In this work, PAA and hypochlorite were compared as disinfectants, with a focus on the effect of wastewater particles. Inactivation experiments were conducted on suspended cultures of Escherichia coli and wastewater suspended solids. Tested size fractions included particle diameters < …

    Date Published:
    2017-12