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  • Author(s):
    Glen Niebur
    Abstract:

    Most patients who succumb to cancer have metastases to bone that contribute to their death. Cancer cells that metastasize to bone are regularly subjected to mechanical stimuli that may affect their proliferation, growth and protein expression. Understanding why some cancer cells thrive in this environment could provide insight into new approaches to prevent or treat metastasis to bone. We used 4T1 cells as a model of breast cancer cells, and implanted them in gelatin hydrogels with moduli of …

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  • Author(s):
    Glen Niebur
    Abstract:

    Most patients who succumb to cancer have metastases to bone that contribute to their death. Cancer cells that metastasize to bone are regularly subjected to mechanical stimuli that may affect their proliferation, growth and protein expression. Understanding why some cancer cells thrive in this environment could provide insight into new approaches to prevent or treat metastasis to bone. We used 4T1 cells as a model of breast cancer cells, and implanted them in gelatin hydrogels with moduli of …

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  • Author(s):
    Erika Hosselkus
    Abstract:

    Colonial Puebla de los Ángeles’ mixed population of Spaniards, creoles, Native Americans, and groups of African descent confronted death frequently. Epidemic disease combined with mundane illnesses and infirmities made dying a quotidian and familiar experience among all social groups. The city’s religious and secular officials recognized death as an important rite of passage and sponsored and supported scripted rituals of death designed to guide the soul to its final resting place. As they ai…

    Date Published:
    2017-04
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  • Author(s):
    Peggy Griesinger, Karl-Rainer Blumenthal, Julia Kim, Shira Peltzman, Vicky Steeves
    Abstract:

    The National Digital Stewardship Alliance surveyed practitioners in 2012 and again in 2017 to gauge, among other things, how satisfied they were with their organizations’ digital preservation function. This study seeks to understand what causes the high and rising levels of dissatisfaction that practitioners reported. We interviewed 21 digital stewards and asked them to describe the organizational context in which they work; to reflect on what aspects of their organizations’ approach to digit…

    Date Published:
    2020-08
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  • Author(s):
    Ji-Young Son, Kevin J. Lane, Marie Lynn Miranda, Michelle L. Bell
    Abstract:

    Understanding the environmental justice implications of the mortality impacts of air pollution exposure is a public health priority, as some subpopulations may face a disproportionate health burden. We examined which residential environmental and social factors may affect disparities in the air pollution-mortality relationship in North Carolina, US, using a time-stratified case-crossover design. Results indicate that air pollution poses a higher mortality risk for some persons (e.g., elderly)…

    Date Published:
    2020-03
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  • Author(s):
    Trevor B. Demille, Robert A. Hughes, Nathaniel Dominique, Jacob E. Olson, Sergei Rouvimov, Jon P. Camden, Svetlana Neretina
    Abstract:

    A method for the nanofabrication of periodic arrays of gold nanostars yielding a unique morphology of relevance to SERS applications. With arms radiating from a central core, gold nanostars represent a unique and fascinating class of nanomaterials from which extraordinary plasmonic properties are derived. Despite their relevance to sensing applications, methods for fabricating homogeneous populations of nanostars on large-area planar surfaces in truly periodic arrays is lacking. Herein, the f…

    Date Published:
    2020-07
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  • Author(s):
    Nora Belzowski, Mark Robison
    Abstract:

    Subject faculty sometimes limit information literacy when they ask a librarian for “the library talk.” On the librarian’s end, this unimaginative request translates into a traditional one-shot, often focused on point-and-click skills rather than building deeper competencies. The authors developed a collaboration rubric to liberate librarians from this deadlock. The rubric uses nine lenses to focus the librarian-instructor collaboration on relevant sub-categories that display various instructi…

    Date Published:
    2019-03
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  • Author(s):
    Zhongmou Chao, Kutay Sezginel, Ke Xu, Garrison Crouch, Abigale Gray, Christopher Wilmer, Paul Bohn, David Go, Susan Fillerton-Shirey
    Abstract:

    Silver nanofilament formation dynamics are reported for an ionic liquid (IL)-filled solid polymer electrolyte prepared by a direct-write process using a conductive atomic force microscope (C-AFM). Filaments are electrochemically formed at hundreds of xy locations on a ≈40 nm thick polymer electrolyte, polyethylene glycol diacrylate (PEGDA)/[BMIM]PF6. Although the formation time generally decreases with increasing bias from 0.7 to 3.0 V, an unexpected non-monotonic maximum is observed ≈2.0 V. …

    Date Published:
    2019-01
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  • Author(s):
    Jason Mason, Jordan A. Cockfield, Daniel Pape, Hannah Meissner, Michael Sokolowski, Taylor C. White, Jose Valentin Lopez, Juan Liu, Xiaojing Liu, Inmaculada martinez-Reyes, Navdeep Chandel, Jason Locasale, Zachary Schafer
    Abstract:

    Loss of integrin-mediated attachment to extracellular matrix (ECM) proteins can trigger a variety of cellular changes that impact cell viability. Foremost among these is the activation of anoikis, caspase-mediated cell death induced by ECM-detachment. In addition to anoikis, loss of ECM-attachment causes profound alterations in cellular metabolism that can lead to anoikis-independent cell death. Here, we describe a surprising role for serum and glucocorticoid kinase-1 (SGK1) in the promotion …

    Date Published:
    2020-03
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  • Author(s):
    Sasha Padilla-Coley, Hui Xu
    Abstract:

    hydrophobic (i.e., Hoechst 33342) dyes or drugs, including a binary dye/drug pair (i.e., indocyanine green/mitoxantrone). The core of HBPn, containing a mixture of uncharged 2-pentanone chains and 1,2,3-triazole rings, could be loaded with uncharged and very hydrophobic dyes (i.e., Nile Red) or drugs. Improved aqueous solubility of camptothecin was achieved 10-fold from 8.4 to 75 ng/mL. Additionally, cell toxicity studies showed that HBPn was able to release the camptothecin drug inside A549 …

    Date Published:
    2020-04
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  • Author(s):
    Frederik J. Steyn, Siobhan Kirk, Tesfay W. Tefera, Teresa Xie, Timothy Tracey, Dean Kelk, Elyse Wimberger, Fleur Garton, Llion Robets, Sarah Chapman, Jeff Coombes, W. Matthew Leevy, Alberto Ferri, Cristiana Valle, Frederique Rene, Jean-Philippe Loeffler, Pamela McCombe, Robert Henderson, Shyuan Ngo
    Abstract:

    Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of upper and lower 36 motor neurons, yet an increasing number of studies in both mouse models and patients with 37 ALS suggest that altered metabolic homeostasis is a feature of disease. Pre-clinical and clinical 38 studies have shown that modulation of energy balance can be beneficial in ALS. However, our 39 capacity to target specific metabolic pathways or mechanisms requires detailed understanding 40 of metabolic dysr…

    Date Published:
    2020-04
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  • Author(s):
    Jeff Harden
    Abstract:

    Governments around the world adopt transparency reforms to facilitate accountability. In principle, open proceedings provide citizens with valuable information to evaluate elected officials’ decisionmaking, which incentives lawmakers to follow mass preferences when choosing policies. However, the public’s general lack of knowledge and engagement with the political process may weaken the power of open information, and perhaps instead allow citizens and groups with extreme views to exer…

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