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  • Author(s):
    Sangnam Kim, Siyuan Zhang, Sangpil Yoon
    Abstract:

    Current advances in ultrasound imaging techniques combined with the next generation contrast agents such as gas vesicles (GV) revolutionize the visualization of biological tissues with spatiotemporal precision. In optics, fluorescent proteins enable understanding of molecular and cellular functions in biological systems due to their multiplexed imaging capability. Here, a panel of GVs is investigated using mid-band fit (MBF) spectral imaging to realize multiplexed ultrasound imaging to unique…

    Date Created:
    2022-08-11
    Record Visibility:
    Public
  • Author(s):
    Yide Zhang, Yinhao Zhu, Evan Nichols, Qingfei Wang, Vignesh Sundaresan, Siyuan Zhang, Cody Smith, Paul W. Bohn, Scott S. Howard
    Abstract:

    Fluorescence microscopy imaging speed is fundamentally limited by the measurement signal-to-noise ratio (SNR). To improve image SNR for a given image acquisition rate, computational denoising techniques can be used to suppress noise.However, common techniques to estimate a denoised image froma single frame either are computationally expensive or rely on simple noise statistical models. These models assume Poisson or Gaussian noise statistics, which are not appropriate for many fluorescence mi…

    Date Published:
    2022-03
    Record Visibility:
    Public
  • Author(s):
    Brant D. Gates, Jackson B. Vyletel, Lei Zou, Matthew Webber
    Abstract:

    The affinity possible from certain supramolecular motifs rivals that for some of the best-recognized interactions in biology. Cucurbit [7] uril (CB[7]) macrocycles, for example, are capable of achieving affinities in their binding to certain guests that rival that of biotin−avidin. Supramolecular host−guest recognition between CB[7] and certain guests has been demonstrated to spatially localize guest-linked agents to desired sites in vivo, offering opportunities to better exploit this affinit…

    Date Published:
    2022-06
    Record Visibility:
    Public
  • Author(s):
    Zhihong Peng, Mohini Mohan Konai, Luis F. Avila-Cobian, Man Wang, Shahriar Mobashery, Mayland Chang
    Abstract:

    Idiopathic pulmonary fibrosis (IPF), a fatal disease characterized by excessive matrix degradation and fibrosis, destroys the lung architecture and results in the inability of the lungs to absorb oxygen. The cause(s) of IPF is unknown and current treatments are palliative. Matrix metalloproteinases (MMPs) and A Disintegrin And Metalloproteinases (ADAMs) likely play roles in IPF progression. However, specific MMPs and ADAMs in IPF have not been identified due to challenges in MMP/ADAM profilin…

    Date Published:
    2022-03
    Record Visibility:
    Public
  • Author(s):
    Brant D. Gates, Jackson B. Vyletel, Lei Zou, Matthew Webber
    Abstract:

    The affinity possible from certain supramolecular motifs rivals that for some of the best-recognized interactions in biology. Cucurbit [7] uril (CB[7]) macrocycles, for example, are capable of achieving affinities in their binding to certain guests that rival that of biotin−avidin. Supramolecular host−guest recognition between CB[7] and certain guests has been demonstrated to spatially localize guest-linked agents to desired sites in vivo, offering opportunities to better exploit this affinit…

    Date Published:
    2022-06
    Record Visibility:
    Public
  • Author(s):
    L. Gallagher, W. T. Barker, V. B. Hubble, J. Gasper, C. Melander, C. Manoil
    Abstract:

    Small molecule adjuvants that enhance the activity of established antibiotics represent promising agents in the battle against antibiotic resistance. Adjuvants generally act by inhibiting antibiotic resistance processes, and specifying the process acted on is a critical step in defining an adjuvant’s mechanism of action. This step is typically carried out biochemically by identifying molecules that bind adjuvants and then inferring their roles in resistance. Here, we present a complementary g…

    Date Published:
    2022-01
    Record Visibility:
    Public
  • Author(s):
    Rashida Callender, Joally M.Canales, Carolina Avendano, Elena Craft, Katherine B. Ensor, Marie Lynn Miranda
    Abstract:

    Objectives To assess the economic and mental health impacts of COVID-19 in the presence of previous exposure to flooding events.

    Methods Starting in April 2018, the Texas Flood Registry (TFR) invited residents to complete an online survey regarding their experiences with Hurricane Harvey and subsequent flooding events. Starting in April 2020, participants nationwide were invited to complete a brief online survey on their experiences during the pandemic. This study includes participan…

    Date Published:
    2022-08
    Record Visibility:
    Public
  • Author(s):
    Bruno Garcia Silva, Patricia Perez-Calleja, Eugenio Foresti, Robert Nerenberg
    Abstract:

    The foam-aerated biofilm reactor (FABR) is a novel biofilm process that can simultaneously remove carbon and nitrogen from wastewater. A porous polyurethane foam sheet forms an interface between wastewater and aerated water, making it a counter-diffusional biofilm process similar to the membrane-aerated biofilm reactor (MABR). However, it is not clear how biofilm develops the foam interior, and how this impacts mass transfer and performance. This research explored biofilm development within t…

    Date Published:
    2022-04
    Record Visibility:
    Public
  • Author(s):
    Mercedes A. Bravo, Dominique Zephyr, Katherine Ensor, Daniel Kowal, Marie Lynn Miranda
    Abstract:

    Racial/ethnic disparities in academic performance may result from a confluence of adverse exposures that arise from structural racism and accrue to specific subpopulations. This study investigates childhood lead exposure, racial residential segregation, and early educational outcomes. Geocoded North Carolina birth data is linked to blood lead surveillance data and fourth-grade standardized test scores (n = 25,699). We constructed a census tract-level measure of racial isolation (RI) of the no…

    Date Published:
    2022-08
    Record Visibility:
    Public
  • Author(s):
    Adam S. Braegelman, Rachel C. Ollier, Bo Su, Christopher J. Addonizio, Lei Zou, Sara L. Cole, Matthew J. Webber
    Abstract:

    Hydrogels prepared from supramolecular cross-linking motifs are appealing for use as biomaterials and drug delivery technologies. The inclusion of macromolecules (e.g., protein therapeutics) in these materials is relevant to many of their intendeduses. However, the impact of dynamic network cross-linking on macromolecule diffusion must be better understood. Here, hydrogel networks with identical topology but disparate cross-link dynamics are explored. These materials are prepared from cross-l…

    Date Published:
    2022-05
    Record Visibility:
    Public
  • Author(s):
    Daniel Lapsley, Thomas Stapleford
    Abstract:

    The empirical study of dispositional humility as a facet of personality and of intellectual humility as an intellectual virtue has increased dramatically in just the last decade. This paper reviews the conceptualization of these constructs as well as the many assessment strategies designed to measure them. With particular focus on the practice of science and the collaborative work of labs, I conclude with the suggestion that the individualism of traditional virtue concepts elides the importan…

    Date Created:
    2022-06-04
    Record Visibility:
    Public
  • Author(s):
    Joost Santos, Sisi Meng, Pallab Mozumder
    Abstract:

    Critical infrastructure systems are essential in the wellbeing and security of the modern society. They are becoming more ubiquitous and large-scale, and their interdependencies have become more and more complex leading to their uncertain behaviors in the aftermath of disruptive events. The prolonged disruptions in public utility services create several negative impacts on the individuals as well as the communities and society as a whole. The paper seeks to develop an integrated economic inpu…

    Date Created:
    2022-05-25
    Record Visibility:
    Public