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  • Author(s):
    Zhihong Pen, Trung T. Nguyen
    Abstract:

    Diabetic foot ulcers (DFUs) are a common complication of diabetes that are recalcitrant to healing due to persistent inflammation. The majority of DFUs have bacterial biofilms, with Staphylococcus epidermidis as a predominant bacterium, requiring infection control with antibiotics before treatment of the wound. Matrix metalloproteinases (MMPs) play roles in the pathology and repair of DFUs. However, defining the roles of the 24 human MMPs has been challenging due to the presence of three form…

    Date Published:
    2020-09
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    Public
  • Author(s):
    Gozde Basara, Mortaza Saeidi-Javash, Xiang Ren, Godhan Bahcecioglu, Brian C. Wyatt, Babak Anasori, Yanliang Zhang, Pinar Zorlutuna
    Abstract:

    Tissue engineered cardiac patches have great potential as a therapeutic treatment for myocardial infarction (MI). However, for successful integration with the native tissue and proper function of the cells comprising the patch, it is crucial for these patches to mimic the ordered structure of the native extracellular matrix and the electroconductivity of the human heart. In this study, a new composite construct that can provide both conductive and topographical cues for human induced pluripot…

    Date Published:
    2020-12
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    Public
  • Author(s):
    Allison Young, Carlysa Oyama, Alejandro ClaureDeLaZerda, Yueying Liu, Matthew J. Ravosa, Vijayalaxmi Gupta, Andrea Jewell, Dineo Khabele, M. Sharon Stack
    Abstract:

    The majority of women with recurrent ovarian cancer (OvCa) develop malignant ascites with volumes that can reach > 2 L. The resulting elevation in intraperitoneal pressure (IPP), from normal values of 5 mmHg to as high as 22 mmHg, causes striking changes in the loading environment in the peritoneal cavity. The effect of ascites-induced changes in IPP on OvCa progression is largely unknown. Herein we model the functional consequences of ascites-induced compression on ovarian tumor cells and…

    Date Published:
    2020-04
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    Public
  • Author(s):
    Mikala Narlock, Daniel Johnson, Julie Vecchio
    Abstract:

    As academic library support services for digital scholarship activities continue to expand and evolve, large volumes of digital outputs have been created by, and in collaboration with, library and information professionals who are affiliated with digital scholarship centers. Drawing on a literature review and a 2018 pilot study of digital preservation services in digital scholarship centers, we propose future directions for investigation of preservation services for digital scholarship and pr…

    Date Published:
    2021-05
    Record Visibility:
    Public
  • Abstract:

    The University of Notre Dame has been awarded a one-year Institute of Museum and Library Services (IMLS) planning grant to assess the need for library-based machine learning and natural language processing tools to facilitate automated metadata creation and classification in support of cross-disciplinary discovery and research. This record contains the final outputs of the project.

    There are four standalone files:

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    Resource Type
    Document
  • Author(s):
    Mikala Narlock, Peggy Griesinger
    Abstract:

    In the article, the authors discuss the process of creating and revising a prioritization rubric created to help compare digital collections while generating stakeholder buy-in. The rubric is currently a low-tech solution to help educate Hesburgh Library stakeholders on the intricacies of digital collections and gather support for the strategic direction of our collection building. This work builds on previous presentations and publications about the Digital Collections Oversight Team at Hesb…

    Date Published:
    2021-01
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    Public
  • Author(s):
    Din Syafruddin, Puji B. S. Asih, Ismail Ekoprayitno Rozi, Dendi Hadi Permana, Anggi Puspa Nur Hidayati, Lepa Syahrani, Siti Zubaidah, Dian Sidik, Michael J. Bangs, Claus Bøgh, Fang Liu, Evercita C. Eugenio, Jared Hendrickson, Timothy Burton, J. Kevin Baird, Frank Collins, John P. Grieco, Neil F. Lobo, Nicole L. Achee
    Abstract:

    A cluster-randomized, double-blinded, placebo-controlled trial was conducted to estimate the protective efficacy (PE) of a spatial repellent (SR) against malaria infection in Sumba, Indonesia. Following radical cure in 1,341 children aged ³ 6 months to £ 5 years in 24 clusters, households were given transfluthrin or placebo passive emanators (devices designed to release vaporized chemical). Monthly blood screening and biweekly human-landing mosquito catches were performed during a 10-month ba…

    Date Published:
    2020
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    Public
  • Author(s):
    Thomas A. Stapleford
    Abstract:

    Scientific research, considered in isolation, is often regarded as an amoral activity. In this view, ethics exists only around the margins of research – perhaps in the choice of topics pursued, the treatment of experimental subjects, or the use of results. Such an account seems to explain why brilliant scientists can be deeply flawed, at times even vicious, human beings. It also reflects a distinction between “making” and “acting” that found its most influential formulation in Aristotle’s dis…

    Date Published:
    2018
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    Public
  • Author(s):
    Thomas A. Stapleford
    Abstract:

    Malcolm Rorty is best known to historians of economics as the primary organizer and founder of the National Bureau of Economic Research. This essay situations Rorty’s interest in economics against the backdrop of his early career in telephone engineering at American Telephone & Telegraph. I argue that distinct structural features of telephone engineering in general, and AT&T in particular, created overlaps between the practices engineering and economics, and also opened space for Rort…

    Date Published:
    2020-12
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    Public
  • Author(s):
    Essaka Joshua
    Abstract:

    “Chaucer’s Ghoast” is an anonymous collection of twelve short poems (one set within a short story in prose) published in London in 1672, and evidently never reprinted since. It has been described as a loose translation of selections from Ovid, and sometimes (e.g. by the NUC) attributed to Charles Cotton (1630-87). Joshua has identified it as a modernization of selections from CA, and reprints ten lines from the two works (from the story of Pygmaleon) to demonstrate the closeness…

    Date Published:
    1997
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    Public
  • Author(s):
    Essaka Joshua
    Abstract:

    The picturesque theorists disagree vehemently over whether the picturesque deformity that can be appreciated in buildings and landscapes could also be appreciated in people with deformities, be these people real or represented. William Gilpin writes about ruins and people in ways that suggest that they possess the same aesthetic value. Fitness for representation is Gilpin’s criterion for a certain type of aesthetic appreciation, and, using this criterion, he regards picturesque deformity in a…

    Date Published:
    2016
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    Public
  • Author(s):
    Essaka Joshua
    Abstract:

    Observes that George Bernard Shaw’s play “Pygmalion” is read in a mythographic context that has generally focused exclusively on its connections to Ovid’s version of the myth, contained in “Metamorphoses.” Argues, borrowing from the theories of Lévi-Strauss, that alternative versions of the Pygmalion myth should be studied, as mythic tales are not “static,” but constantly refined through retellings. Explains the use of “contextualisation” in the…

    Date Published:
    1998
    Record Visibility:
    Public