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  • Author(s):
    Patrick Milhoan
    Abstract:

    Over the past 20 years, the creation of databases of digitized climate records have made invaluable resources available to study climate change. Beginning in 2000, NOAA’s Climate Database Modernization Program digitized climate related records resulting in the creation of 56 million climate-related images. The Climatological Database for the World’s Oceans (CLIWOC) project digitized and transcribed ships’ logbooks that recorded weather data during their voyages. These entries provide rese…

    Date Created:
    2019-06-19
    Record Visibility:
    Public
    Resource Type
    Presentation
  • Author(s):
    Hyein Do, Seung-Ryong Kwon, Seol Baek, Chinedu Madukoma, Marina Smiley, Lars Dietrich, Joshua Shrout, Paul Bohn
    Abstract:

    The opportunistic pathogen Pseudomonas aeruginosa (P. aeruginosa) produces several redox-Active phenazine metabolites, including pyocyanin (PYO) and phenazine-1-carboxamide (PCN), which are electron carrier molecules that also aid in virulence. In particular, PYO is an exclusive metabolite produced by P. aeruginosa, which acts as a virulence factor in hospital-Acquired infections and is therefore a good biomarker for identifying early stage colonization by this pathogen. Here, we describe the…

    Date Published:
    2021-01
    Record Visibility:
    Public
  • Author(s):
    Hyein Do, Seung-Ryong Kwon, Seol Baek, Chinedu S. Madukoma, Marina Smiley, Lars Dietrich, Joshua Shrout, Paul Bohn
    Abstract:

    The opportunistic pathogen Pseudomonas aeruginosa (P. aeruginosa) produces several redox-Active phenazine metabolites, including pyocyanin (PYO) and phenazine-1-carboxamide (PCN), which are electron carrier molecules that also aid in virulence. In particular, PYO is an exclusive metabolite produced by P. aeruginosa, which acts as a virulence factor in hospital-Acquired infections and is therefore a good biomarker for identifying early stage colonization by this pathogen. Here, we describe the…

    Date Published:
    2021-01
    Record Visibility:
    Public
  • Author(s):
    Mikala Narlock
    Abstract:

    This presentation was provided for the “Moment to see, Courage to act” initiative led by the Provost’s Office. This presentation focuses on the Marble project, a grant-funded initiative to build a unified discovery and exhibition platform for the Snite Museum of Art and the Hesburgh Libraries.

    Background from the Provost’s Office: And the reality of course is that the challenges will likely continue. We can end up wherever these challenges toss us. Alternatively, we can dec…

    Date Created:
    2021-04-13
    Record Visibility:
    Public
    Resource Type
    Presentation
  • Author(s):
    Lauren Ajamie, Melissa Harden
    Abstract:

    This article presents a case study in which one library designated Product Owners to steer a website redesign project. The Product Owner, commonly used in agile approaches to software development, plays an important leadership role in the development process. In the case described here, two faculty librarians were selected to co-lead the project. This article outlines the benefits of using Product Owners and the factors that led to the two librarians being put on the project. The authors exp…

    Date Published:
    2021-04
    Record Visibility:
    Public
  • Author(s):
    Paul Bohn
    Abstract:

    We present the results of acid-base experiments performed at the single ion (H+ or OH-) limit in ∼6 aL volume nanopores incorporating electrochemical zero-mode waveguides (E-ZMWs). At pH 3 each E-ZMW nanopore contains ca. 3600H+ ions, and application of a negative electrochemical potential to the gold working electrode/optical cladding layer reduces H+ to H2, thereby depleting H+ and increasing the local pH within the nanopore. The change in pH was quantified by tracking the intensity of fluo…

    Date Published:
    2020-09
    Record Visibility:
    Public
  • Author(s):
    Seol Baek, Seung-Ryong Kwon, Kaiyu Fu, Paul Bohn
    Abstract:

    NEA nanopores. Such selectively transported and confined ions are detected by using a 100 nm gap dual-ring nanoelectrode structure capable of enhancing current output by efficient redox cycling with an amplification factor >102. In addition, BCP@NEAs exhibit extraordinary pH-gated ion selectivity, resulting in a 3380-fold current difference between anion and cation probes at pH 3.0. This hierarchically organized BCP-gated NEA system can serve as a template for the development of other stim…

    Date Published:
    2020-11
    Record Visibility:
    Public
  • Creator(s):
    Matthew Sisk
    Description:

    Data related to the publication “Palliative Care in Uganda: Quantitative Descriptive Study of Key Palliative Care Indicators 2018-2019”

    This is a placeholder and will be updated with the data upon completion.

    Date Created:
    2021-03-09
    Record Visibility:
    Public
  • Author(s):
    Madhav Joshi
    Abstract:

    This report provides an overview of the current implementation status of the Doha Agreement negotiated between the Taliban and the United States on February 29, 2020, using the Peace Accords Matrix (PAM)—a methodology for monitoring and assessing implementation of comprehensive peace agreements developed by the University of Notre Dame’s Kroc Institute for International Peace Studies. The Agreement is divided into three parts containing 14 specific provisions/commitments, of which 11 are anal…

    Date Created:
    2021-03-23
    Record Visibility:
    Public
    Resource Type
    Report
  • Author(s):
    Zhihong Pen, Trung T. Nguyen
    Abstract:

    Diabetic foot ulcers (DFUs) are a common complication of diabetes that are recalcitrant to healing due to persistent inflammation. The majority of DFUs have bacterial biofilms, with Staphylococcus epidermidis as a predominant bacterium, requiring infection control with antibiotics before treatment of the wound. Matrix metalloproteinases (MMPs) play roles in the pathology and repair of DFUs. However, defining the roles of the 24 human MMPs has been challenging due to the presence of three form…

    Date Published:
    2020-09
    Record Visibility:
    Public
  • Author(s):
    Gozde Basara, Mortaza Saeidi-Javash, Xiang Ren, Godhan Bahcecioglu, Brian C. Wyatt, Babak Anasori, Yanliang Zhang, Pinar Zorlutuna
    Abstract:

    Tissue engineered cardiac patches have great potential as a therapeutic treatment for myocardial infarction (MI). However, for successful integration with the native tissue and proper function of the cells comprising the patch, it is crucial for these patches to mimic the ordered structure of the native extracellular matrix and the electroconductivity of the human heart. In this study, a new composite construct that can provide both conductive and topographical cues for human induced pluripot…

    Date Published:
    2020-12
    Record Visibility:
    Public
  • Author(s):
    Allison Young, Carlysa Oyama, Alejandro ClaureDeLaZerda, Yueying Liu, Matthew J. Ravosa, Vijayalaxmi Gupta, Andrea Jewell, Dineo Khabele, M. Sharon Stack
    Abstract:

    The majority of women with recurrent ovarian cancer (OvCa) develop malignant ascites with volumes that can reach > 2 L. The resulting elevation in intraperitoneal pressure (IPP), from normal values of 5 mmHg to as high as 22 mmHg, causes striking changes in the loading environment in the peritoneal cavity. The effect of ascites-induced changes in IPP on OvCa progression is largely unknown. Herein we model the functional consequences of ascites-induced compression on ovarian tumor cells and…

    Date Published:
    2020-04
    Record Visibility:
    Public