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  • Author(s):
    Yide Zhang
    Abstract:

    Multiphoton microscopy combined with fluorescence lifetime imaging microscopy (MPM-FLIM) is a technique that allows for imaging the lifetime of fluorescence created by two-photon excitation. It not only possesses the advantages of MPM such as large imaging depth, but also the strengths of FLIM including the ability to discriminate different fluorophores with similar emission spectra. In FLIM, the frequency-domain (FD) method, which relies on periodic intensity-modulated excitation light and i…

    Date Created:
    2015-10-22
    Record Visibility:
    Public
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    In cancer and all biomedical researches, we always need a microscope with better imaging precision, speed, functionality, and depth, so that the diagnostics and treatments of cancer and other diseases can be accurate, fast, and noninvasive. However, conventional fluorescence microscopes cannot satisfy these needs due to physical limits on resolution, speed, information, and depth. In this work, we aim to overcome these limits using novel super-resolution microscopy and high-speed quantitative…

    Date Created:
    2018-04-09
    Record Visibility:
    Public
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    Multiphoton microscopy (MPM) is a widely used in vivo imaging technique in biological and medical applications. In the case of two-photon excitation fluorescence, two lower-energy photons excite a fluorophore which in turn emits a single higher-energy photon, whose rate depends quadratically on the excitation intensity, thus enabling higher resolution with narrower point spread function (PSF) than conventional one-photon fluorescence microscopy. Fluorescence lifetime imaging microscopy (FLIM)…

    Date Created:
    2016-04-04
    Record Visibility:
    Public
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    To fundamentally understand biological and medical phenomena such as aging and diseases, we need the information of the microenvironment surrounding living cells. We propose the multiphoton fluorescence lifetime imaging microscopy (MPM-FLIM) platform with super-sensitivity and super-resolution capabilities to quantitatively obtain this information at the intracellular level. First, we present a simple MPM oxygen imaging probe compatible with aqueous biological media based on water-soluble rut…

    Date Created:
    2017-03-30
    Record Visibility:
    Public
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    Super-resolution fluorescence microscopy is an important tool in biomedical research for its ability to discern features smaller than the diffraction limit, but its universal application is not feasible due to its difficult implementation and high cost. In this research, we propose and demonstrate a new kind of super-resolution fluorescence microscopy that can be easily implemented and requires neither additional hardware nor complex post-processing. The microscopy is based on the principle o…

    Date Created:
    2017-10-19
    Record Visibility:
    Public
    Resource Type
    Presentation
  • Author(s):
    Kyle Sweeney, Douglas Thain
    Abstract:

    Scientists using workflows often have access to both High Performance Computing and High-Throughput Computing sites, but HPC sites’ architecture is less conducive to HTC paradigms. The choices of middleware and site can have drastic performance differences on different workflows. To explore these differences, we created tools to expand Makeflow and Work Queue’s capabilities. We then performed four speed of light tests, testing job dispatch rate, data delivery from the master to worker…

    Record Visibility:
    Public
  • Author(s):
    Stewart Clem
    Abstract:

    In recent scholarship, moral theologians and readers of Thomas Aquinas have shown increasing sensitivity to the role of the passions in the moral life. Yet these accounts have paid inadequate attention to Thomas’s writings on Christ’s passions as a source of moral reflection. As I argue in this essay, Thomas’s writings on Christ’s human affectivity should not be limited to the concerns of Christology; rather, they should be integrated into a fuller account of the human passions. One upshot of…

    Date Published:
    2018-07
    Record Visibility:
    Public
  • Author(s):
    Stewart Clem
    Abstract:

    Philosopher Harry Frankfurt has famously coined “bullshit” as a technical term— it refers not to outright lying but rather to a casual indifference to truth. Disregard for truth is accepted and even expected in many contexts, yet it creates conditions for gross injustice and dehumanization. I offer an account of widespread cultural indifference to truth as structural sin, a condition I call “truth indifference.” Drawing on Thomas Aquinas’s understanding of the virtue of truth (veracitas), I m…

    Date Published:
    2017-12
    Record Visibility:
    Public
  • Author(s):
    Stewart Clem
    Abstract:

    In this article, I argue that Immanuel Kant fails to provide a satisfactory account of ‘moral debt’ in Religion within the Boundaries of Mere Reason. More precisely, he fails to answer the question of why we should assume that a debt exists in the first place. In light of recent scholarship on this area of his thought, I sketch some possible readings of Kant on the nature of moral transformation that suggest how he might account for this debt. I then argue that these accounts fail to justify …

    Date Published:
    2018-03
    Record Visibility:
    Public
  • Author(s):
    Kenton Murray, David Chiang
    Abstract:

    Neural networks have been shown to improve performance across a range of natural-language tasks. However, designing and training them can be complicated. Frequently, researchers resort to repeated experimentation to pick optimal settings. In this paper, we address the issue of choosing the correct number of units in hidden layers. We introduce a method for automatically adjusting network size by pruning out hidden units through L∞,1 and L2,1 regularization. We apply this method to language mo…

    Record Visibility:
    Public
  • 11

    Article

    Author(s):
    Haiyan Meng
    Abstract:

    Computational reproducibility depends on being able to isolate necessary and sufficient computational artifacts and preserve them for later re-execution. Both isolation and preservation of artifacts can be challenging due to the complexity of existing software and systems and the resulting implicit dependencies, resource distribution, and shifting compatibility of systems as time progresses—all conspiring to break the reproducibility of an application. Sandboxing is a technique that has bee…

    Record Visibility:
    Public